2-Hydroxyestradiol

Modify Date: 2024-01-09 07:41:56

2-Hydroxyestradiol structure	Common Name	2-Hydroxyestradiol
	CAS Number	362-05-0	Molecular Weight	288.38
	Density	1.2±0.1 g/cm3	Boiling Point	481.5±45.0 °C at 760 mmHg
	Molecular Formula	C₁₈H₂₄O₃	Melting Point	96-104°C
	MSDS	Chinese USA	Flash Point	227.6±23.3 °C
	Symbol	GHS08	Signal Word	Warning

Use of 2-Hydroxyestradiol

2-Hydroxyestradiol, a metabolite of 17β-estradiol with minimal estrogenic activity, possesses antioxidant effects and reacts with DNA to form stable adducts and exerts genotoxicity[1][3].

Name	2-hydroxy-17β-estradiol
Synonym	More Synonyms

Description	2-Hydroxyestradiol, a metabolite of 17β-estradiol with minimal estrogenic activity, possesses antioxidant effects and reacts with DNA to form stable adducts and exerts genotoxicity[1][3].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
In Vitro	2-Hydroxyestradiol induces phenotypical changes indicative of neoplastic transformation[1]. 2-Hydroxyestradiol (2-OHE2) is capable of in vitro transforming a HBEC, MCF-10F cell line, that is estrogen receptor-a (ERα) negative and ERβ positive[1]. 2-Hydroxyestradiol induces oxidative DNA damage and apoptosis in human mammary epithelial cells[3].
In Vivo	2-Hydroxyestradiol attenuated the development of obesity and improved endothelial function, decreased nephropathy, decreased the severity of diabetes, lowered arterial blood pressure, and reduced plasma cholesterol[2].
References	[1]. C H Van Aswegen, et al. Binding of 2-hydroxyestradiol and 4-hydroxyestradiol to estrogen receptors from human breast cancers. J Steroid Biochem. 1989 Apr;32(4):485-92. [2]. S P Tofovic, et al. 2-Hydroxyestradiol attenuates the development of obesity, the metabolic syndrome, and vascular and renal dysfunction in obese ZSF1 rats. J Pharmacol Exp Ther. 2001 Dec;299(3):973-7. [3]. Yeon-Jin Hurh, et al. 2-Hydroxyestradiol induces oxidative DNA damage and apoptosis in human mammary epithelial cells. J Toxicol Environ Health A. 2004 Dec;67(23-24):1939-53.

Density	1.2±0.1 g/cm3
Boiling Point	481.5±45.0 °C at 760 mmHg
Melting Point	96-104°C
Molecular Formula	C₁₈H₂₄O₃
Molecular Weight	288.38
Flash Point	227.6±23.3 °C
Exact Mass	288.172546
PSA	60.69000
LogP	3.53
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.622
Storage condition	−20°C

2-Hydroxyestradiol MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KG7675000

CHEMICAL NAME :: Estra-1,3,5(10)-triene-2,3,17-beta-triol

CAS REGISTRY NUMBER :: 362-05-0

BEILSTEIN REFERENCE NO. :: 2219367

LAST UPDATED :: 199709

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C18-H24-O3

MOLECULAR WEIGHT :: 288.42

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 1280 ng/kg

SEX/DURATION :: male 8 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - other effects on male Endocrine - androgenic

REFERENCE :: ANDRDQ Andrologia. (Grosse Verlag GmbH, Kurfuerstenstr. 112-113, D-1000 Berlin 30, Fed. Rep. Ger.) V.6- 1974- Volume(issue)/page/year: 23,339,1991

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 10 ug/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina

REFERENCE :: EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 42,165,1986

Symbol	GHS08
Signal Word	Warning
Hazard Statements	H351
Precautionary Statements	P281
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn: Harmful;
Risk Phrases	40
Safety Phrases	S22;S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	KG7675000

Precursor 6
CAS#:362-07-2 2-Methoxyestradiol CAS#:50-28-2 beta-Estradiol CAS#:5976-65-8 3-methoxy-13-me... CAS#:23463-05-0 estra-1,3,5(10)...
CAS#:3589-91-1 3,17β-bis(2-tet... CAS#:19590-55-7 Estra-1,3,5(10)...
DownStream 4
CAS#:362-06-1 2-hydroxyestrone CAS#:362-07-2 2-Methoxyestradiol CAS#:5976-65-8 3-methoxy-13-me... CAS#:5976-67-0 2-METHOXYESTRAD...

A methoxyflavonoid, chrysoeriol, selectively inhibits the formation of a carcinogenic estrogen metabolite in MCF-7 breast cancer cells.

J. Steroid Biochem. Mol. Biol. 118(1-2) , 70-6, (2010)

A 17beta-estradiol (E(2)) is hydrolyzed to 2-hydroxy-E(2) (2-OHE(2)) and 4-hydroxy-E(2) (4-OHE(2)) via cytochrome P450 (CYP) 1A1 and 1B1, respectively. In estrogen target tissues including the mammary...

Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals.

J. Med. Chem. 48 , 5666-74, (2005)

We investigated the influence of induced fit of the androgen receptor binding pocket on free energies of ligand binding. On the basis of a novel alignment procedure using flexible docking, molecular d...

Norethisterone acetate alters coagulation gene expression in vitro in human cell culture.

Thromb. Res. 131(1) , 72-7, (2013)

Both oestrogen and progestin and the route of administration have been implicated in cardiovascular and thromboembolic risk in post menopausal hormone users. Transdermal preparations have been reporte...

Estra-1,3,5(10)-triene-2,3,17β-triol

2-Hydroxy-17b-estradiol

2-hydroxy-17β-estradiol

2-hydroxy-17beta-estradiol

MFCD00010490

(17β)-Estra-1(10),2,4-triene-2,3,17-triol

Estra-1,3,5(10)-triene-2,3,17-triol, (17β)-

2-Hydroxyestradiol

2,3,17b-Trihydroxyestra-1,3,5(10)-triene

estra-1(10),2,4-triene-2,3,17-triol, (17β)-

Estra-1,3,5(10)-triene-2,3,17-β-triol

(17b)-Estra-1(10),2,4-triene-2,3,17-triol

(17β)-Estra-1,3,5(10)-triene-2,3,17-triol

2-hydroxy-estradiol

2-Oh-estradiol

Estra-1,3,5(10)-triene-2,3,17b-triol

2-Hydroxy-17-estradiol

Shanghai Nianxing Industrial Co., Ltd
China
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China
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ShangHai DC Chemicals Co.,Ltd
China
Product Name: 2-Hydroxyestradiol
Price: ￥Inquiry/1g
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Estra-1,3,5(10)-triene-2,3,17-triol,(17b)-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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2-Hydroxyestradiol

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