376362-03-7
376362-03-7 structure
- Name: 1-(4-Hydroxy-2-Methoxyphenyl)-3-(4-hydroxy-3-prenylphenyl)propane
- Chemical Name: 4-[3-(4-Hydroxy-2-methoxyphenyl)propyl]-2-(3-methyl-2-buten-1-yl) phenol
- CAS Number: 376362-03-7
- Molecular Formula: C21H26O3
- Molecular Weight: 326.429
- Catalog: Natural product Phenols
- Create Date: 2016-10-05 08:48:12
- Modify Date: 2025-08-25 15:11:43
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1-(4-Hydroxy-2-methoxyphenyl)-3-(4-hydroxy-3-prenylphenyl), isolated from Broussonetia kazinoki, shows in vitro inhibition of protein tyrosine phosphatase 1B (PTP1B) with an IC50 of 13.00 μM. PTP1B is a negative regulator of insulin action and an important mediator in the pathogenesis of insulinresistance and non-insulin dependent diabetes mellitus. PTP1B is regarded as a significant target for type 2 diabetes[1].
| Name | 4-[3-(4-Hydroxy-2-methoxyphenyl)propyl]-2-(3-methyl-2-buten-1-yl) phenol |
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| Synonyms |
Phenol, 4-[3-(4-hydroxy-2-methoxyphenyl)propyl]-2-(3-methyl-2-buten-1-yl)-
4-[3-(4-Hydroxy-2-methoxyphenyl)propyl]-2-(3-methyl-2-buten-1-yl)phenol |
| Description | 1-(4-Hydroxy-2-methoxyphenyl)-3-(4-hydroxy-3-prenylphenyl), isolated from Broussonetia kazinoki, shows in vitro inhibition of protein tyrosine phosphatase 1B (PTP1B) with an IC50 of 13.00 μM. PTP1B is a negative regulator of insulin action and an important mediator in the pathogenesis of insulinresistance and non-insulin dependent diabetes mellitus. PTP1B is regarded as a significant target for type 2 diabetes[1]. |
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| Related Catalog | |
| References |
| Density | 1.1±0.1 g/cm3 |
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| Boiling Point | 490.3±40.0 °C at 760 mmHg |
| Molecular Formula | C21H26O3 |
| Molecular Weight | 326.429 |
| Flash Point | 250.3±27.3 °C |
| Exact Mass | 326.188202 |
| PSA | 49.69000 |
| LogP | 5.74 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.581 |
| Hazard Codes | Xi |
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