78782-99-7

78782-99-7 structure

Name: Calcitriol D6
Chemical Name: (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-7a-methyl-1-[(2R)-7,7,7-trideuterio-6-hydroxy-6-(trideuteriomethyl)heptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
CAS Number: 78782-99-7
Molecular Formula: C₂₇H₃₈D₆O₃
Molecular Weight: 422.67300
Catalog: Signaling Pathways Vitamin D Related VD/VDR
Create Date: 2017-12-16 13:08:18
Modify Date: 2026-07-07 17:36:27
Calcitriol D6 is the deuterated form of Calcitriol(1,25-Dihydroxyvitamin D3; Rocaltrol ), which is the hormonally active form of vitamin D, Calcitriol is the active metabolite of vitamin D3 that activates the vitamin D receptor (VDR).IC50 value:Target: vitamin D receptorCalcitriol(1,25-Dihydroxyvitamin D3; Rocaltrol ) displays calcemic actions. Calcitriol stimulates intestinal and renal Ca2+ absorption and regulates bone Ca2+ turnover. Calcitriol (1,25-Dihydroxyvitamin D3; Rocaltrol )exhibits antitumor activity; Calcitriol(1,25-Dihydroxyvitamin D3; Rocaltrol ) inhibits in vivo and in vitro cell proliferation in a wide range of cells including breast, prostate, colon, skin and brain carcinomas and myeloid leukemia cells.

Name	(1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-7a-methyl-1-[(2R)-7,7,7-trideuterio-6-hydroxy-6-(trideuteriomethyl)heptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
Synonyms	Soltriol-d6 2H6]-Calcitriol（[2H6]-1,25-DihydroxyVitamin D3） 1α,25-DihydroxyvitaMin D3-d6 1α,25-Dihydroxycholecalciferol-d6 Ro 5-d6 D6-Calcitriol（D6-1,25-DihydroxyVitamin D3） (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7-7a-methyl-1-[(2R)-7,7,7-trideuterio-6-hydroxy-6-(trideuteriomethyl)htan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol (1a,3,5Z,7E)- 9,10-Secocholesta-5,7,10-triene-1,3,25-triol-d6 1α,25-Dihydroxyvitamin D3-26,26,26,27,27,27-d solution (1R,3S,5Z)-4-Methylene-5-[(2E)-2-[(1R,3aS,7aS)-octahydro-1-[(1R)-5-hydroxy-1,5-diMethylhexyl]-7a-Methyl-4H-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol-d6 (1R,3S,5Z)-4-methylene-5-[(2E)-2-[(1R,3aS,7-octahydro-1-[(1R)-5-hydroxy-1-methyl-5-(methyl-d3)hexyl-6,6,6-d3]-7a-methyl-4H-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol 1-alpha, 25-Dihydroxy Vitamin D3-d6 1alpha,25-Dihydroxyvitamin D3-[26,26,26,27,27,27]-d6 (1α,3β,5Z,7E)- 9,10-Secocholesta-5,7,10-triene-1,3,25-triol-d6 Solbone P-d6 Panbonis-d6 Calcitriol-d6 1alpha,25-Dihydroxyvitamin D3-[26,26,26,27,27,27]-2H6 Rocaltrol-d6 Vitamin D13 Injection 1-alpha,25-Dihydroxy Vitamin D3-d6 [2H6]-Calcitriol Calcitriol D6Q: What is Calcitriol D6 Q: What is the CAS Number of Calcitriol D6 Q: What is the storage condition of Calcitriol D6 Q: What e the applications of Calcitriol D6 1alpha,25-Dihydroxyvitamin D3-26,26,26,27,27,27-d6 solution 1,25-DihydroxyvitaMin D3-[D6] Calcitriol-D6 DihydroxyvitaMin D3-d6 1a,25-Dihydroxycholecalciferol-d6 Calcijex-d6 Toptriol-d6 (1R,3S,Z)-5-(2-((1R,3aS,7,E)-1-((R)-6-hydroxy-6-(methyl-d3)htan-2-yl-7,7,7-d3)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol Topitriol-d6 1a,25-Dihydroxyvitamin D3-d6 1α,25-Dihydroxyvitamin D3-26,26,26,27,27,27-d6 solution Silkis-d6

Description	Calcitriol D6 is the deuterated form of Calcitriol(1,25-Dihydroxyvitamin D3; Rocaltrol ), which is the hormonally active form of vitamin D, Calcitriol is the active metabolite of vitamin D3 that activates the vitamin D receptor (VDR).IC50 value:Target: vitamin D receptorCalcitriol(1,25-Dihydroxyvitamin D3; Rocaltrol ) displays calcemic actions. Calcitriol stimulates intestinal and renal Ca2+ absorption and regulates bone Ca2+ turnover. Calcitriol (1,25-Dihydroxyvitamin D3; Rocaltrol )exhibits antitumor activity; Calcitriol(1,25-Dihydroxyvitamin D3; Rocaltrol ) inhibits in vivo and in vitro cell proliferation in a wide range of cells including breast, prostate, colon, skin and brain carcinomas and myeloid leukemia cells.
Related Catalog	Signaling Pathways >> Vitamin D Related >> VD/VDR Research Areas >> Metabolic Disease
References	[1]. Canalejo et al (2000) The in vitro effect of calcitriol on parathyroid cell proliferation and apoptosis. J.Am.Soc.Nephrol. 11 1865. Beer and Myrthue (2004) [2]. Calcitriol in cancer treatment: from the lab to the clinic. Mol.Cancer Ther. 3 373. [3]. Nijenhuis et al (2006) The novel vitamin D analog ZK191784 as an intestine-specific vitamin D antagonist. FASEB J. 20 1589. [4]. Krishnan AV, Swami S, Feldman D.Equivalent anticancer activities of dietary vitamin D and calcitriol in an animal model of breast cancer: Importance of mammary CYP27B1 for treatment and prevention.J Steroid Biochem Mol Biol. 2012 Aug 23. [5]. Alkharfy KM, Al-Daghri NM, Yakout SM, Ahmed M.Calcitriol Attenuates Weight-Related Systemic Inflammation and Ultrastructural Changes of the Liver in a Rodent Model.Basic Clin Pharmacol Toxicol. 2012 Aug 21.

Molecular Formula	C₂₇H₃₈D₆O₃
Molecular Weight	422.67300
Exact Mass	422.36700
PSA	60.69000
LogP	5.70470
Storage condition	2-8℃

Symbol	GHS02, GHS07
Signal Word	Danger
Hazard Statements	H225-H319
Precautionary Statements	P210-P305 + P351 + P338-P370 + P378-P403 + P235
RIDADR	UN1170 - class 3 - PG 2 - Ethanol, solution
Flash Point(F)	57.2 °F
Flash Point(C)	14 °C

78782-98-6

~15%

78782-99-7

Literature: Coldwell; Traford; Varley; Kirk; Makin Steroids, 1990 , vol. 55, # 10 p. 418 - 432

Precursor 1
78782-98-6
DownStream 0

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