78782-99-7

• 常用中文名：骨化三醇 D6
• 常用英文名：Calcitriol D6
• CAS号：78782-99-7
• 分子式：C₂₇H₃₈D₆O₃
• 分子量：422.67300
• 相关类别： 信号通路 维生素 D 相关 VD/VDR
• 发布时间：2017-12-16 13:08:18
• 更新时间：2026-07-07 17:36:27
• Calcitriol D6是骨化三醇的含重氢形式，骨化三醇是维生素D3的活性代谢物。

名称

• 中文名: 骨化三醇 D6
• 英文名: (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-7a-methyl-1-[(2R)-7,7,7-trideuterio-6-hydroxy-6-(trideuteriomethyl)heptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
• 中文别名: 1-ALPHA,25-二羟基维生素 D3-D6; 2H6]-骨化三醇 ([2H6]-1,25-二羟基维生素D3); 维生素D13杂质; [2H6]-骨化三醇; 1,25-双羟基维他命-骨化三醇-D6; 氘6-骨化三醇(氘6-1,25-二羟基维生素氘3)
• 英文别名: Soltriol-d6; 2H6]-Calcitriol（[2H6]-1,25-DihydroxyVitamin D3）; 1α,25-DihydroxyvitaMin D3-d6; 1α,25-Dihydroxycholecalciferol-d6; Ro 5-d6; D6-Calcitriol（D6-1,25-DihydroxyVitamin D3）; (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7-7a-methyl-1-[(2R)-7,7,7-trideuterio-6-hydroxy-6-(trideuteriomethyl)htan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol; (1a,3,5Z,7E)- 9,10-Secocholesta-5,7,10-triene-1,3,25-triol-d6; 1α,25-Dihydroxyvitamin D3-26,26,26,27,27,27-d solution; (1R,3S,5Z)-4-Methylene-5-[(2E)-2-[(1R,3aS,7aS)-octahydro-1-[(1R)-5-hydroxy-1,5-diMethylhexyl]-7a-Methyl-4H-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol-d6; (1R,3S,5Z)-4-methylene-5-[(2E)-2-[(1R,3aS,7-octahydro-1-[(1R)-5-hydroxy-1-methyl-5-(methyl-d3)hexyl-6,6,6-d3]-7a-methyl-4H-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol; 1-alpha, 25-Dihydroxy Vitamin D3-d6; 1alpha,25-Dihydroxyvitamin D3-[26,26,26,27,27,27]-d6; (1α,3β,5Z,7E)- 9,10-Secocholesta-5,7,10-triene-1,3,25-triol-d6; Solbone P-d6; Panbonis-d6; Calcitriol-d6; 1alpha,25-Dihydroxyvitamin D3-[26,26,26,27,27,27]-2H6; Rocaltrol-d6; Vitamin D13 Injection; 1-alpha,25-Dihydroxy Vitamin D3-d6; [2H6]-Calcitriol; Calcitriol D6Q: What is Calcitriol D6 Q: What is the CAS Number of Calcitriol D6 Q: What is the storage condition of Calcitriol D6 Q: What e the applications of Calcitriol D6; 1alpha,25-Dihydroxyvitamin D3-26,26,26,27,27,27-d6 solution; 1,25-DihydroxyvitaMin D3-[D6] Calcitriol-D6; DihydroxyvitaMin D3-d6; 1a,25-Dihydroxycholecalciferol-d6; Calcijex-d6; Toptriol-d6; (1R,3S,Z)-5-(2-((1R,3aS,7,E)-1-((R)-6-hydroxy-6-(methyl-d3)htan-2-yl-7,7,7-d3)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol; Topitriol-d6; 1a,25-Dihydroxyvitamin D3-d6; 1α,25-Dihydroxyvitamin D3-26,26,26,27,27,27-d6 solution; Silkis-d6

物化性质

• 分子式: C₂₇H₃₈D₆O₃
• 分子量: 422.67300
• 精确质量: 422.36700
• PSA: 60.69000
• LogP: 5.70470
• 储存条件: 2-8℃

生物活性

• 描述: Calcitriol D6是骨化三醇的含重氢形式,骨化三醇是维生素D3的活性代谢物。
• 相关类别:
  信号通路 >> 维生素 D 相关 >> VD/VDR
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Canalejo et al (2000) The in vitro effect of calcitriol on parathyroid cell proliferation and apoptosis. J.Am.Soc.Nephrol. 11 1865. Beer and Myrthue (2004)

  [2]. Calcitriol in cancer treatment: from the lab to the clinic. Mol.Cancer Ther. 3 373.

  [3]. Nijenhuis et al (2006) The novel vitamin D analog ZK191784 as an intestine-specific vitamin D antagonist. FASEB J. 20 1589.

  [4]. Krishnan AV, Swami S, Feldman D.Equivalent anticancer activities of dietary vitamin D and calcitriol in an animal model of breast cancer: Importance of mammary CYP27B1 for treatment and prevention.J Steroid Biochem Mol Biol. 2012 Aug 23.

  [5]. Alkharfy KM, Al-Daghri NM, Yakout SM, Ahmed M.Calcitriol Attenuates Weight-Related Systemic Inflammation and Ultrastructural Changes of the Liver in a Rodent Model.Basic Clin Pharmacol Toxicol. 2012 Aug 21.

安全

• 符号: GHS02, GHS07
• 信号词: Danger
• 危害声明: H225-H319
• 警示性声明: P210-P305 + P351 + P338-P370 + P378-P403 + P235
• 危险品运输编码: UN1170 - class 3 - PG 2 - Ethanol, solution
• 闪点（华氏）: 57.2 °F
• 闪点（摄氏）: 14 °C

合成路线

78782-98-6 ~15% 78782-99-7

文献：Coldwell; Traford; Varley; Kirk; Makin Steroids, 1990 , vol. 55, # 10 p. 418 - 432

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