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342-69-8

342-69-8 structure
342-69-8 structure
  • Name: Inosine,6-S-methyl-6-thio
  • Chemical Name: 6-methylthioinosine
  • CAS Number: 342-69-8
  • Molecular Formula: C11H14N4O4S
  • Molecular Weight: 298.32
  • Catalog: Biochemical Nucleoside drugs Nucleoside intermediate
  • Create Date: 2018-07-11 11:57:39
  • Modify Date: 2026-06-30 19:44:12
  • 6-Methylmercaptopurine riboside is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Name 6-methylthioinosine
Synonyms nci-c04784
6-METHYLMERCAPTOPURINE RIBOSIDE
6-(methylthio)-9-beta-d-ribofuranosyl-9h-purin
MFCD00022826
6-(methylthio)-9-beta-D-ribofuranosyl-9H-purine
6-SMe-PuR
6-METHYLMERCAPTOPURINE RIBOSIDE //BP
6-(methylthio)-9-β-d-ribofuranosyl-9h-purine
6-Methylmercaptopurinribosid
6-methylmp-riboside
6-(methylthio)purineribonucleoside
nsc40774
6-Methylmercapto-9-(β-D-ribofuranosyl) purine
beta-d-ribosyl-6-methylthiopurine
EINECS 206-442-2
6-methyl-9-ribofuranosylpurine-6-thiol
6-Methylmercapto-9-(β-D-ribofuranosyl)purine
6-Methylthioinosine
6-MMPR
6-Methylmercaptopurine riboside
6-(methylthio)-inosin
6-Methylmercapto-9-(b-D-ribofuranosyl)purine
6-MethylthiopurineRiboside,6-MMPR,Methylthioinosine
(2R,3S,4R,5R)-2-(hydroxymethyl)-5-[6-(methylsulfanyl)-9H-purin-9-yl]oxolane-3,4-diol
6-MethylmercaptopurineRiboside
Inosine, 6-S-methyl-6-thio
6-METHYLMERCAPTOPURINE RIBONUCLEOSIDE
6-(METHYLTHIO)-9-BETA-D-RIBOFURANOSYLPURINE
SQ-21977
6-methyl-9-ribofuranosyl-purine-6-thio
METHYLTHIOINOSINE
(2R,3S,4R,5R)-2-(hydroxyMethyl)-5-(6-(Methylthio)-9H-purin-9-yl)tetrahydrofuran-3,4-diol
6-METHYLTHIOPURINE RIBOSIDE
Mercaptopurine Impurity 28
Description 6-Methylmercaptopurine riboside is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog
References

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Density 1.85g/cm3
Boiling Point 636.3ºC at 760mmHg
Melting Point 166°C
Molecular Formula C11H14N4O4S
Molecular Weight 298.32
Flash Point 338.6ºC
Exact Mass 298.07400
PSA 138.82000
Index of Refraction 1.822
Storage condition −20°C
Stability Incompatible with strong oxidizing agents.

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UO8985000
CHEMICAL NAME :
9H-Purine, 6-(methylthio)-9-beta-D-ribofuranosyl-
CAS REGISTRY NUMBER :
342-69-8
BEILSTEIN REFERENCE NO. :
0042871
LAST UPDATED :
199612
DATA ITEMS CITED :
10
MOLECULAR FORMULA :
C11-H14-N4-O4-S
MOLECULAR WEIGHT :
298.35
WISWESSER LINE NOTATION :
T56 BN DN FN HNJ IS1 D- BT5OTJ CQ DQ E1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
65 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
137 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD10 - Lethal Dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
20 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
44 mg/kg/7W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Endocrine - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
780 mg/kg/26W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Endocrine - adrenal cortex tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
65 mg/kg
SEX/DURATION :
female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death

MUTATION DATA

TYPE OF TEST :
Mutation test systems - not otherwise specified
TEST SYSTEM :
Rodent - mouse Lymphocyte
DOSE/DURATION :
3 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 43,1587,1983
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases S22-S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS UO8985000
HS Code 29349990
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