DC Chemicals Limited
China
Product Name: Kinetin riboside
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Purity: 98.0%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Adenosine,N-(2-furanylmethyl)-
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Purity: 98.0%
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4338-47-0

4338-47-0 structure

4338-47-0 structure

Name: Kinetin riboside
Chemical Name: kinetin riboside
CAS Number: 4338-47-0
Molecular Formula: C₁₅H₁₇N₅O₅
Molecular Weight: 347.326
Catalog: Biochemical Nucleoside drugs Nucleoside intermediate
Create Date: 2018-06-30 02:11:23
Modify Date: 2024-01-02 11:41:40
Kinetin riboside, a cytokinin analog, can induce apoptosis in cancer cells. It inhibits the proliferation of HCT-15 cells with an IC50 of 2.5 μM.

Name	kinetin riboside
Synonyms	9H-Purin-6-amine, N-(2-furanylmethyl)-9-pentofuranosyl- N-(2-Furylmethyl)-9-pentofuranosyl-9H-purin-6-amine furfuryladenosine EINECS 224-389-3 6-Furfurylaminopurine riboside (N6-(2-Furanylmethyl)adenosine Kinetin-9-riboside MFCD00037987 n-furfuryl-adenosin Ribosylkinetin N-Furfuryladenosine

Description	Kinetin riboside, a cytokinin analog, can induce apoptosis in cancer cells. It inhibits the proliferation of HCT-15 cells with an IC50 of 2.5 μM.
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
Target	IC50: 2.5 μM (HCT-15 cells)[1]
In Vitro	Kinetin riboside displays antiproliferative and apoptogenic activity against various human cancer cell lines. Kinetin riboside is able to inhibit the proliferation in HCT-15 human colon cancer cells in a dose-dependent manner (IC50=2.5 μM)[1]. Kinetin riboside induces apoptosis in HeLa and mouse melanoma B16F-10 cells. Kinetin riboside disrupts the mitochondrial membrane potential and induces the release of cytochrome c and activation of caspase-3. Bad are up-regulated while Bcl-2 is down-regulated under kinetin riboside exposure[2].
In Vivo	Kinetin riboside significantly suppresses tumor growth. The most effective anti-melanoma response is elicited at 40 mg/kg[2].
Cell Assay	HeLa and mouse melanoma B16F-10 cells are treated with 5, 10, 20 μM kinetin riboside for 48 h. 15 μL of MTT solution (5 mg/mL) is added to each well and cells are maintained for 4 h at 37°C. Hundred microlitres of solubilizing solution is then added. After an overnight incubation at room temperature, absorbance at 490 nm is measured[2].
Animal Admin	Mice: Male C57BL/6 mice are injected B16 F-10 cells. After 5 days for tumor growth, kinetin riboside (10, 20, 40 mg/kg) is injected to tumor mass directly. Drug injection is performed once a 3 days for three times. After third injection of drug, mice are kept for 3 days with no injection and tumor mass is removed from each mouse and weighed[2].
References	[1]. Rajabi M, et al. Antiproliferative activity of kinetin riboside on HCT-15 colon cancer cell line. Nucleosides Nucleotides Nucleic Acids. 2012;31(6):474-81. [2]. Choi BH, et al. Kinetin riboside preferentially induces apoptosis by modulating Bcl-2 family proteins and caspase-3 in cancer cells. Cancer Lett. 2008 Mar 8;261(1):37-45.

Density	1.8±0.1 g/cm3
Boiling Point	683.7±65.0 °C at 760 mmHg
Melting Point	152-154ºC
Molecular Formula	C₁₅H₁₇N₅O₅
Molecular Weight	347.326
Flash Point	367.3±34.3 °C
Exact Mass	347.122955
PSA	138.69000
LogP	0.20
Vapour Pressure	0.0±2.2 mmHg at 25°C
Index of Refraction	1.798
Storage condition	2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AU7400200

CHEMICAL NAME :: Adenosine, N-furfuryl-

CAS REGISTRY NUMBER :: 4338-47-0

BEILSTEIN REFERENCE NO. :: 0059588

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C15-H17-N5-O5

MOLECULAR WEIGHT :: 347.37

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Human Leukocyte

DOSE/DURATION :: 100 umol/L

REFERENCE :: EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 32,29,1976

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	AU7400200
HS Code	29349990

Precursor 9
4753-68-8 2004-06-0 98-01-1 58-61-7
617-89-0 105499-44-3 1121-47-7 342-69-8
7387-58-8
DownStream 2
525-79-1 18646-11-2