Inosine,6-S-methyl-6-thio

Modify Date: 2025-08-26 16:45:03

Inosine,6-S-methyl-6-thio structure	Common Name	Inosine,6-S-methyl-6-thio
	CAS Number	342-69-8	Molecular Weight	298.32
	Density	1.85g/cm3	Boiling Point	636.3ºC at 760mmHg
	Molecular Formula	C₁₁H₁₄N₄O₄S	Melting Point	166°C
	MSDS	Chinese USA	Flash Point	338.6ºC

Use of Inosine,6-S-methyl-6-thio

6-Methylmercaptopurine riboside is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Name	6-methylthioinosine
Synonym	More Synonyms

Description	6-Methylmercaptopurine riboside is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
References	[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Density	1.85g/cm3
Boiling Point	636.3ºC at 760mmHg
Melting Point	166°C
Molecular Formula	C₁₁H₁₄N₄O₄S
Molecular Weight	298.32
Flash Point	338.6ºC
Exact Mass	298.07400
PSA	138.82000
Index of Refraction	1.822
InChIKey	ZDRFDHHANOYUTE-IOSLPCCCSA-N
SMILES	CSc1ncnc2c1ncn2C1OC(CO)C(O)C1O
Storage condition	−20°C
Stability	Incompatible with strong oxidizing agents.

Inosine,6-S-methyl-6-thio MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UO8985000

CHEMICAL NAME :: 9H-Purine, 6-(methylthio)-9-beta-D-ribofuranosyl-

CAS REGISTRY NUMBER :: 342-69-8

BEILSTEIN REFERENCE NO. :: 0042871

LAST UPDATED :: 199612

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C11-H14-N4-O4-S

MOLECULAR WEIGHT :: 298.35

WISWESSER LINE NOTATION :: T56 BN DN FN HNJ IS1 D- BT5OTJ CQ DQ E1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 65 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 137 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD10 - Lethal Dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 44 mg/kg/7W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Endocrine - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 780 mg/kg/26W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Endocrine - adrenal cortex tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 65 mg/kg

SEX/DURATION :: female 11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Rodent - mouse Lymphocyte

DOSE/DURATION :: 3 umol/L

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 43,1587,1983

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	UO8985000
HS Code	29349990

Precursor 9
CAS#:5188-07-8 Sodium thiomethoxide CAS#:7387-57-7 2',3',5'-Tri-O-... CAS#:58-61-7 Adenosine CAS#:163632-54-0 9-(β-D-ribofura...
CAS#:66782-10-3 tri-O-benzoyl-1... CAS#:74-88-4 methyl iodide CAS#:6974-32-9 b-D-Ribofuranos... CAS#:50-66-8 6-(Methylthio)purine
CAS#:73237-86-2 (2R,3R,4R,5R)-2...
DownStream 9
CAS#:50-66-8 6-(Methylthio)purine CAS#:18646-11-2 α-D-ribofuranos... CAS#:4338-47-0 Kinetin riboside CAS#:58-61-7 Adenosine
CAS#:23526-11-6 Inosine,2'-deox... CAS#:42021-78-3 [7,7-dimethyl-2... CAS#:132154-36-0 N-(9-β-D-ribofu... CAS#:4542-23-8 N6-Succinyl Ade...
CAS#:53665-01-3 2-(6-aziridin-1...

The role of inosine-5'-monophosphate dehydrogenase in thiopurine metabolism in patients with inflammatory bowel disease.

Ther. Drug Monit. 33 , 200-208, (2011)

There is a large interindividual variability in thiopurine metabolism. High concentrations of methylthioinosine-5'-monophosphate (meTIMP) and low concentrations of 6-thioguanine nucleotides (6-TGNs) h...

Methylthioadenosine deaminase in an alternative quorum sensing pathway in Pseudomonas aeruginosa.

Biochemistry 51(45) , 9094-103, (2012)

Pseudomonas aeruginosa possesses an unusual pathway for 5'-methylthioadenosine (MTA) metabolism involving deamination to 5'-methylthioinosine (MTI) followed by N-ribosyl phosphorolysis to hypoxanthine...

A prospective, open-label trial of 6-thioguanine in patients with ulcerative or indeterminate colitis.

Scand. J. Gastroenterol. 40(10) , 1205-13, (2005)

6-thioguanine (6-TG) has emerged as a promising therapeutic alternative in patients with Crohn's disease intolerant or resistant to azathioprine (AZA) and/or 6-mercaptopurine (6-MP). The aim of the pr...

Name: Concentration required to inhibit HSV type 1 strain HF induced cytopathogenic affects...
Source: ChEMBL
Target: Human alphaherpesvirus 1
External Id: CHEMBL694222

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External Id: CHEMBL800916

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Source: ChEMBL
Target: Human alphaherpesvirus 2
External Id: CHEMBL696293

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Source: ChEMBL
Target: Human alphaherpesvirus 1
External Id: CHEMBL877527

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Source: ChEMBL
Target: Human respirovirus 3
External Id: CHEMBL762072

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Source: ChEMBL
Target: Eimeria tenella
External Id: CHEMBL674773

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Target: Severe acute respiratory syndrome-related coronavirus
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Source: ChEMBL
Target: Erythroleukemia cell line
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Source: ChEMBL
Target: Human adenovirus 2
External Id: CHEMBL641423

Total 28, Current Page 1 of 3

EINECS 206-442-2

6-MethylmercaptopurineRiboside

MFCD00022826

6-Methylthioinosine

METHYLTHIOINOSINE

6-Methylmercaptopurinribosid

6-methylmp-riboside

6-MMPR

6-METHYLTHIOPURINE RIBOSIDE

6-Methylmercaptopurine riboside

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Product Name: 6-MethylmercaptopurineRiboside
Price: Check
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Inosine,6-S-methyl-6-thio-
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Purity: 98.0%
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