- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Bisindolylmaleimide IV
- Price: ￥1958.0/250mg
- Purity: 95.0%
- Stocking Period: 2 Day
- Contact: Liu jia
- DC Chemicals Limited
- China
- Product Name: Bisindolylmaleimide IV
- Price:
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: 3,4-BIS(3-INDOLYL)MALEIMIDE
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
119139-23-0
119139-23-0 structure
- Name: Bisindolylmaleimide IV
- Chemical Name: Bisindolylmaleimide IV
- CAS Number: 119139-23-0
- Molecular Formula: C20H13N3O2
- Molecular Weight: 327.336
- Catalog: Signaling Pathways Anti-infection CMV
- Create Date: 2018-04-10 08:00:00
- Modify Date: 2024-01-02 15:12:37
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Bisindolylmaleimide IV (Arcyriarubin A) is a potent protein kinase C (PKC) inhibitor, with IC50s ranging from 0.1 to 0.55 μM. Bisindolylmaleimide IV also inhibits PKA (IC50=3.1-11.8μM)[1]. Bisindolylmaleimide IV is a potent, selective inhibitor of human cytomegalovirus (HCMV) replication in cell culture with an IC50 of 0.2 μM[2].
| Name | Bisindolylmaleimide IV |
|---|---|
| Synonyms |
MFCD00236432
3,4-bis(1H-indol-3-yl)pyrrole-2,5-dione 2,3-bis-(1h-indol-3-yl)-maleimide 3,4-Bis(3-indolyl)maleimide 3,4-Di(1H-indol-3-yl)-1H-pyrrole-2,5-dione 1H-Pyrrole-2,5-dione, 3,4-di-1H-indol-3-yl- |
| Description | Bisindolylmaleimide IV (Arcyriarubin A) is a potent protein kinase C (PKC) inhibitor, with IC50s ranging from 0.1 to 0.55 μM. Bisindolylmaleimide IV also inhibits PKA (IC50=3.1-11.8μM)[1]. Bisindolylmaleimide IV is a potent, selective inhibitor of human cytomegalovirus (HCMV) replication in cell culture with an IC50 of 0.2 μM[2]. |
|---|---|
| Related Catalog | |
| Target |
PKC:0.1-0.55 μM (IC50) HCMV:0.2 μM (IC50) |
| In Vitro | Bisindolylmaleimide IV (Arcyriarubin A) inhibits PKC with an IC50 of 0.1 μM in 1 % DMSO, while the IC50 of 0.55 μM in 10 % DMSO[1]. |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 690.1±55.0 °C at 760 mmHg |
| Molecular Formula | C20H13N3O2 |
| Molecular Weight | 327.336 |
| Flash Point | 371.2±31.5 °C |
| Exact Mass | 327.100769 |
| PSA | 77.75000 |
| LogP | 3.21 |
| Vapour Pressure | 0.0±2.2 mmHg at 25°C |
| Index of Refraction | 1.811 |
| Storage condition | -20℃ |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| RIDADR | NONH for all modes of transport |
| HS Code | 2933990090 |
| Precursor 10 | |
|---|---|
| DownStream 4 | |
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |