Shanghai Nianxing Industrial Co., Ltd
China
Product Name: OBAA
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: OBAA
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

134531-42-3

134531-42-3 structure

134531-42-3 structure

Name: OBAA
Chemical Name: 2-(3-octadecylbenzoyl)prop-2-enoic acid
CAS Number: 134531-42-3
Molecular Formula: C₂₈H₄₄O₃
Molecular Weight: 428.64700
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2018-12-05 11:23:35
Modify Date: 2024-01-12 14:38:33
OBAA is a potent phospholipase A2 (PLA2) inhibitor with an IC50 of 70 nM. OBAA blocks Melittin-induced Ca2+ influx in Trypanosoma brucei with an IC50 of 0.4 μM[1][2][3].

Name	2-(3-octadecylbenzoyl)prop-2-enoic acid
Synonyms	OBAA 4-(4-octadecylphenyl)-4-oxo-2-Butenoic acid 3-(4-octadecyl)benzoylacrylic acid

Description	OBAA is a potent phospholipase A2 (PLA2) inhibitor with an IC50 of 70 nM. OBAA blocks Melittin-induced Ca2+ influx in Trypanosoma brucei with an IC50 of 0.4 μM[1][2][3].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Signaling Pathways >> Metabolic Enzyme/Protease >> Phospholipase Research Areas >> Inflammation/Immunology
Target	PLA2:70 nM (IC50)
In Vitro	OBAA (5.7 μM) induces apoptotic cell death of human umbilical vein endothelial cells (HUVEC). After 16 h of treatment, almost all of the cells had disintegrated into apoptotic bodies[1].
In Vivo	The immunologically induced bronchospasm in guinea pigs is significantly and dose-dependently inhibited by OBAA (2.5-7 mg/kg i.v.)[3].
References	[1]. J Y Miao, et al. Inhibitors of phospholipase promote apoptosis of human endothelial cells. J Biochem. 1997 Mar;121(3):612-8. [2]. J Eintracht, et al. Calcium entry in Trypanosoma brucei is regulated by phospholipase A2 and arachidonic acid. Biochem J. 1998 Dec 15;336 ( Pt 3)(Pt 3):659-66. [3]. T Köhler, et al. Phospholipase A2 inhibition by alkylbenzoylacrylic acids. Biochem Pharmacol. 1992 Aug 18;44(4):805-13.

Density	0.974 g/cm3
Boiling Point	550.8ºC at 760 mmHg
Molecular Formula	C₂₈H₄₄O₃
Molecular Weight	428.64700
Flash Point	301ºC
Exact Mass	428.32900
PSA	54.37000
LogP	8.31410

RIDADR	NONH for all modes of transport

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