Top Suppliers:I want be here
Related CAS#:
112568-12-4 625092-10-6
120287-85-6 2060024-81-7
2059943-95-0 2060036-41-9
2060037-30-9 2060038-57-3
2059945-12-7 2059942-44-6
2059938-52-0 2060029-93-6
2059940-70-2

112568-12-4

112568-12-4 structure
112568-12-4 structure
  • Name: Antide
  • Chemical Name: Antide
  • CAS Number: 112568-12-4
  • Molecular Formula: C82H108ClN17O14
  • Molecular Weight: 1591.293
  • Catalog: Biochemical Peptide
  • Create Date: 2018-06-21 11:28:55
  • Modify Date: 2024-01-03 00:48:05
  • Antide (D-21074) is a potent LHRH antagonist. Antide also can be used for the research of prostatic cancer.
Name Antide
Synonyms D-Alaninamide, N-acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-N-(3-pyridinylcarbonyl)-L-lysyl-N-(3-pyridinylcarbonyl)-D-lysyl-L-leucyl-N-(1-meth ylethyl)-L-lysyl-L-prolyl-
3-pyridinyl)-d-alanyl-l-seryl-n(sup6)-(3-pyridinylcarbonyl)-l-lysyl-n(sup6)
AC-(D-NAL)-(D-P-CL-PHE)-(D-PAL)-SER-LYS(NICOTINOYL)-[D-LYS(NICOTINOYL)]-LEU-LYS(ISOPROPYL)-PRO-[D-ALA]-NH2
Iturelix
N-[(4R,7R,10R,13S,16S)-16-{[(8S,11S,14R)-8-{[(2S)-2-{[(2R)-1-Amino-1-oxopropan-2-yl]carbamoyl}pyrrolidin-1-yl]carbonyl}-11-isobutyl-2-methyl-10,13,20-trioxo-20-(pyridin-3-yl)-3,9,12,19-tetraazaicosan-14-yl]carbamoyl}-7-(4-chlorobenzyl)-13-(hydroxymethyl)-4-(2-naphthylmethyl)-2,5,8,11,14-pentaoxo-10-(pyridin-3-ylmethyl)-3,6,9,12,15-pentaazaicosan-20-yl]nicotinamide (non-preferred name)
N-Acetyl-3-(2-naphthyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-N-(3-pyridinylcarbonyl)-L-lysyl-N-(3-pyridinylcarbonyl)-D-lysyl-L-leucyl-N-isopropyl-L-lysyl-L-prolyl -D-alaninamide
lyl
AC-DNAL-D: P-CLPHE-DPAL-SER-LYS: NICOTINOYL-DLYS: NICOTINOYL-LEU-LYS: ISOPROPYL-PRO-DALA-NH2
Description Antide (D-21074) is a potent LHRH antagonist. Antide also can be used for the research of prostatic cancer.
Related Catalog
In Vivo Antide (subcutaneously; 1, 3, 6, 10 and 15 mg/kg; once or on 5 consecutive days) can induce a long-term chemical castration in adult male rats and cynomolgus monkeys[1]. Animal Model: Cynomolgus monkey and rat[1] Dosage: 1, 3, 6, 10 and 15 mg/kg Administration: Subcutaneous, once or on 5 consecutive days Result: Had a dose-dependent inhibitory effect on serum concentration of LH (only rat) and testosterone and on the weights of the testes, prostates and seminal vesicles. Achieved long-lasting castration-like effects at concentrations between 6 (less than or equal to 8 weeks) and 15 mg/kg (greater than 8 weeks) in the rat. Induced a prolonged inhibitory effect only at 15 mg/kg and the duration was only 2-3 weeks in the cynomolgus monkey.
References

[1]. U F Habenicht, et al. Effect of the new potent LHRH antagonist antide. J Steroid Biochem Mol Biol. 1990 Dec 20;37(6):937-42.  

Density 1.3±0.1 g/cm3
Boiling Point 1798.0±65.0 °C at 760 mmHg
Molecular Formula C82H108ClN17O14
Molecular Weight 1591.293
Flash Point 1041.2±34.3 °C
Exact Mass 1589.795044
PSA 454.43000
LogP 4.91
Appearance Solid | White to off-white
Vapour Pressure 0.0±0.3 mmHg at 25°C
Index of Refraction 1.593
Storage condition −20°C
Symbol GHS08
GHS08
Signal Word Danger
Hazard Statements H360
Precautionary Statements P201-P308 + P313
Personal Protective Equipment Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes T: Toxic;
Risk Phrases R60
Safety Phrases S53-S22-S36/37/39-S45
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS AY2961700
98266-33-2 structure

98266-33-2

57292-44-1 structure

57292-44-1

76985-10-9 structure

76985-10-9

78545-07-0 structure

78545-07-0

~%

Detail
Literature: Journal of Medicinal Chemistry, , vol. 35, # 23 p. 4270 - 4278
Total: 1 Page

Chemsrc provides CAS#:112568-12-4 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 112568-12-4 | Chemsrc address: https://m.chemsrc.com/en/baike/589116.html

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved