26988-72-7

26988-72-7 structure

Name: (Rac)-Indoximod
Chemical Name: 1-methyltryptophan
CAS Number: 26988-72-7
Molecular Formula: C₁₂H₁₄N₂O₂
Molecular Weight: 218.25200
Catalog: Biochemical Amino acids and their derivatives Tryptophan derivatives
Create Date: 2018-07-17 14:51:50
Modify Date: 2024-01-02 15:15:34
(Rac)-Indoximod (1-Methyl-DL-tryptophan) is an indoleamine 2,3-dioxygenase (IDO) inhibitor. Co-treatment with IFN-γ and (Rac)-Indoximod markedly reduces the activity of human cardiac myofibroblasts (hCMs) expressing α-SMA and induces apoptosis through up-regulating the IRF-1, Fas, and FasL genes[1].

Name	1-methyltryptophan
Synonyms	racemic N-methyl tryptophan methyl tryptophan 1-methyl-D,L-tryptophan DL-1-Methyltryptophan 1-MT EINECS 248-157-6 racemic-1-methyl-D-tryptophan MFCD00005803 2-amino-3-(1-methylindol-3-yl)propanoic acid L-Tryptophan,1-methyl 2-Amino-3-(1-methyl-1H-indol-3-yl)propanoic acid 1-Methyl-tryptophan

Description	(Rac)-Indoximod (1-Methyl-DL-tryptophan) is an indoleamine 2,3-dioxygenase (IDO) inhibitor. Co-treatment with IFN-γ and (Rac)-Indoximod markedly reduces the activity of human cardiac myofibroblasts (hCMs) expressing α-SMA and induces apoptosis through up-regulating the IRF-1, Fas, and FasL genes[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Indoleamine 2,3-Dioxygenase (IDO) Research Areas >> Inflammation/Immunology
Target	IDO
In Vitro	(Rac)-Indoximod (1-Methyl-DL-tryptophan; 0.5 mM; 3 days) inhibits tryptophan depletion, thereby partially reversing the growth-inhibitory activity of IFN-γ, but eventually induces cell death regardless of tryptophan depletion[1]. Cell Viability Assay[1] Cell Line: Human cardiac myofibroblasts (hCMs) Concentration: 0.5 mM Incubation Time: 3 days Result: Growth retardation by IFN-γ was partially reversed on day 2, but cell viability was further reduced on day 3.
References	[1]. Jun-Won Lee,et al. Co-treatment with interferon-γ and 1-methyl tryptophan ameliorates cardiac fibrosis through cardiac myofibroblasts apoptosis. Mol Cell Biochem. 2019 Aug;458(1-2):197-205.

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2933990090

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%