402-71-1
402-71-1 structure
- Name: Tosyl phenylalanyl chloromethyl ketone
- Chemical Name: N-tosyl-L-phenylalanyl chloromethyl ketone
- CAS Number: 402-71-1
- Molecular Formula: C17H18ClNO3S
- Molecular Weight: 351.848
- Catalog: Biochemical Protein research
- Create Date: 2018-07-24 18:53:41
- Modify Date: 2026-08-02 19:55:58
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TPCK (L-1-Tosylamido-2-phenylethyl chloromethyl ketone; L-TPCK) is a potent serine protease inhibitor that reacts with the retinoblastoma protein (RB)-binding core of HPV-18 E7 protein and abolish its RB-binding capability. TPCK is able to modify E7 protein in live keratinocytes following its addition to the culture medium[1].
| Name | N-tosyl-L-phenylalanyl chloromethyl ketone |
|---|---|
| Synonyms |
MFCD00000935
L-1-TOSYLAMIDE-2-PHENYLETHYL-CHLOROMETHYL KETONE N-ALPHA-TOSYL-PHE CHLOROMETHYL KETONE N-p-Tosyl-L-phenylalanine chloromethyl ketone,(S)-1-Chloro-3-tosylamido-4-phenyl-2-butanone, (S)-1-Chloro-4-phenyl-3-tosylamido-2-butanone, TPCK, Tosyl-L-phenylalanyl-chloromethane TOS-PHE-CHLOROMETHYLKETONE TPCK (N-TOSYL-L-PHENYLALANINE CHLOROMETH YL KETONE) \ PROTEASE INHIBITOR (S)-N-(4-Chloro-3-oxo-1-phenyl-2-butyl)-p-toluenesulfonamide N-Tosyl-L-phenylalanyl Chloromethyl Ketone TPCK N-(p-Toluenesulfonyl)-L-phenylalanyl ChloroMethyl Ketone Chloro-3-tosylamido-4-phenyl-2-butanone N-p-Tosyl-L-phenylalanyl chloromethane Tosyl-L-phenylalanyl-chloromethane TPCK (Tosyl Phenylalanyl ChloroMethyl ketone (-)-p-toluenesulfonamid (S)-1-CHLORO-4-PHENYL-3-TOSYLAMIDO-2-BUTANONE L-1-4'-TOSYLAMINO-2-PHENYLETHYL CHLOROMETHYL KETONE N-α-Tosyl-L-phenylalanylchloromethane TOS-PHE-CMK l-1-tosylamido-2-phenylethylchloromethylketone Tosylphenylalanylchloromethane l-n-(alpha-(chloroacetyl)phenethyl)-p-toluenesulfonamide L-1-4‘-Tosylamino-2-phenylethyl chloromethyl ketone N-Tosyl-L-phenylalanine Chloromethyl Ketone(TPCK) Tosyl-L-Phenylalanine chloromethylketone (TLC) L-1-CHLORO-3-(4-TOSYLAMIDO)-4-PHENYL-2-BUTANONE N-alpha-Tosyl-L-phenylalanylchloromethane Tos-L-Phe-Chloromethane N-[(2S)-4-Chloro-3-oxo-1-phenyl-2-butanyl]-4-methylbenzenesulfonamide (S)-N-(4-Chloro-3-oxo-1-phenylbutan-2-yl)-4-methylbenzenesulfonamide L-chloromethyl (2-phenyl-1-(p-toluenesulphonylamino)ethyl) ketone N-p-Tosyl-L-phenylalanine chloromethyl ketone N-Tosyl-L-phenylalanyl Chloromethyl Ketone L-1-4'-Tosylamino-2-phenylethyl chloromethyl ketoneTPCK tosylphenylalanylchloromethylketone P-TOLUENESULFONYL-L-PHENYLALANINE CHLOROMETHYL KETONE n-2-p-Tosyl-L-phenylalanine-chlorometjylketone N-p-Tosyl-L-phenylalanine chloromethyl ketone (TPCK) TOSYL-L-PHENYLALANYL-CHLOROMETHANE L-1-4'-Tosylamino-2-phenylethylechloromethyleketone alpha-N-Tosyl-L-phenylalanine chloromethyl ketone N-(p-Toluenesulfonyl)-L-phenylalanine chloromethyl ketone (S)-N-(4-Chloro-3-oxo-1-phenyl-2-butyl)-p-toluenesulfonamide Chloro-3-tosylaMido-4-phenyl-2-butanone ade L-1-PA-TOSYLAMINO-2-PHENYLETHYLCHLOROMETHYLKETONE TPCK N-[(2S)-4-Chloro-3-oxo-1-phenylbutan-2-yl]-4-methylbenzenesulfonamide N-(p-Toluenesulfonyl)-L-phenylalanyl Chloromethyl Ketone N-TOSYLAMIDE PHENETHYL CHLOROMETHYLKETONE N-ALPHA-P-TOSYL-L-PHENYLALANINE CHLOROMETHYIKETONE L-1-CHLORO-3-TOSYLAMIDO-4-PHENYL-2-BUTANONE L-1-P-TOSYLAMINO-2-PHENYLETHYL CHLORO-METHYL KETONE N-TOSYL-L-PHENYLALANINE CHLOROMETHYL KETONE EINECS 206-954-6 Tos-L-Phe-CMK N- (p-toluenesulfonyl) -L- phenylalanyl chloride ketone (TPCK) L-1-CHLORO-3-TOSYLAMIDO-4-PHENYL-2-BUTANONE ADE TOSYL-L-PHENYLALANINE CHLOROMETHYL KETONE N-p-Tosyl-L-phenylalanyl chloromethyl ketone L-1-P-TOSYLAMINO-2-PHENYLETHYL CHLOROMETHYL KETONE n-p-tosyl-l-phenylalanine chloromethyl ketone L-1-4′-Tosylamino-2-phenylethyl chloromethyl ketone (S)-1-Chloro-3-tosylamido-4-phenyl-2-butanone, (S)-1-Chloro-4-phenyl-3-tosylamido-2-butanone, Tosyl-L-phenylalanyl-chloromethane, TPCK (S)-1-CHLORO-3-TOSYLAMIDO-4-PHENYL-2-BUTANONE N-TOSYL-PHE-CHLOROMETHYLKETONE L-1-TOSYLAMIDO-2-PHENYLETHYLCHLOROETHYLKETONE Benzenesulfonamide, N-(1S)-3-chloro-2-oxo-1-(phenylmethyl)propyl-4-methyl L-1-4-Tosylamido-2-phenylethyl chloromethyl ketone N-[(S)-α-(Chloroacetyl)phenethyl]-4-methylbenzenesulfonamide |
| Description | TPCK (L-1-Tosylamido-2-phenylethyl chloromethyl ketone; L-TPCK) is a potent serine protease inhibitor that reacts with the retinoblastoma protein (RB)-binding core of HPV-18 E7 protein and abolish its RB-binding capability. TPCK is able to modify E7 protein in live keratinocytes following its addition to the culture medium[1]. |
|---|---|
| Related Catalog | |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 509.9±60.0 °C at 760 mmHg |
| Melting Point | 106-108ºC(lit.) |
| Molecular Formula | C17H18ClNO3S |
| Molecular Weight | 351.848 |
| Flash Point | 262.2±32.9 °C |
| Exact Mass | 351.069580 |
| PSA | 71.62000 |
| LogP | 3.98 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.583 |
| Storage condition | −20°C |
| Water Solubility | DMSO: >10 mg/mL stable for several months at 4°C. |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
| Symbol |
GHS05, GHS07 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H315-H318-H335 |
| Precautionary Statements | P261-P280-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | R37/38 |
| Safety Phrases | 26-36 |
| RIDADR | UN 3335 |
| WGK Germany | 3 |
| RTECS | XT5613500 |