404009-40-1

404009-40-1 structure

Name: 1-(2-hydroxy-4-morpholin-4-ylphenyl)ethanone
Chemical Name: 1-(2-hydroxy-4-morpholin-4-ylphenyl)ethanone
CAS Number: 404009-40-1
Molecular Formula: C₁₂H₁₅NO₃
Molecular Weight: 221.252
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2017-06-13 12:07:20
Modify Date: 2024-01-05 16:46:29
IC 86621 is a potent DNA-dependent protein kinase (DNA-PK) inhibitor, with an IC50 of 120 nM. IC 86621 also acts as a selective and reversible ATP-competitive inhibitor.IC 86621 inhibits DNA-PK mediated cellular DNA double-strand break (DSB) repair (EC50=68 µM). IC 86621 increases DSB-induced antitumor activity without cytotoxic effects. IC 86621 can protects rheumatoid arthritis (RA) T cells from apoptosis[1][2].

Name	1-(2-hydroxy-4-morpholin-4-ylphenyl)ethanone
Synonyms	1-[2-Hydroxy-4-(4-morpholinyl)phenyl]ethanone AR2783 1-(2-Hydroxy-4-morpholin-4-yl-phenyl)ethanone DNA-PK Inhibitor III HMS3229C13 1-(2-hydroxy-4-morpholin-4-ylphenyl)ethanone Ethanone, 1-[2-hydroxy-4-(4-morpholinyl)phenyl]-

Description	IC 86621 is a potent DNA-dependent protein kinase (DNA-PK) inhibitor, with an IC50 of 120 nM. IC 86621 also acts as a selective and reversible ATP-competitive inhibitor.IC 86621 inhibits DNA-PK mediated cellular DNA double-strand break (DSB) repair (EC50=68 µM). IC 86621 increases DSB-induced antitumor activity without cytotoxic effects. IC 86621 can protects rheumatoid arthritis (RA) T cells from apoptosis[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> DNA-PK Research Areas >> Inflammation/Immunology Signaling Pathways >> PI3K/Akt/mTOR >> DNA-PK
Target	IC50: 120 nM (DNA-PK)[1]
In Vitro	IC 86621 exhibits high selectivity against other kinases such as PI3K, Cdk2, Src, PKA, PKC, Chk1, CK1, ATM, and FKBP12[1]. IC 86621 (0-100 nM, 24 h) protects RA (rheumatoid arthritis) T cells from apoptosis[2]. Apoptosis Analysis[2] Cell Line: CD4+CD45RO- T cells (from six control donors and seven RA patients) Concentration: 0 nM, 50 nM, 100 nM Incubation Time: 24 h Result: Protected RA (rheumatoid arthritis) T cells from apoptosis.
References	[1]. Chandra G, et al. Improved synthesis of a DNA-dependent protein kinase inhibitor IC86621. Arch Pharm Res. 2012 Mar;35(4):639-45. [2]. Shao L, et al. DNA-dependent protein kinase catalytic subunit mediates T-cell loss in rheumatoid arthritis. EMBO Mol Med. 2010 Oct;2(10):415-27.

Density	1.2±0.1 g/cm3
Boiling Point	425.5±45.0 °C at 760 mmHg
Molecular Formula	C₁₂H₁₅NO₃
Molecular Weight	221.252
Flash Point	211.1±28.7 °C
Exact Mass	221.105194
PSA	49.77000
LogP	1.40
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.570
Storage condition	-20℃

HS Code	2934999090

70362-07-1

~25%

404009-40-1

Literature: Halbrook, James; Kesicki, Edward A.; Burgess, Laurence E.; Schlachter, Stephen T.; Eary, Charles T.; Schiro, Justin G; Huang, Hongmei; Evans, Michael; Han, Yongxin Patent: US2002/165218 A1, 2002 ; US 20020165218 A1

917-54-4

70362-07-1

~17%

404009-40-1

Literature: Knight, Zachary A.; Chiang, Gary G.; Alaimo, Peter J.; Kenski, Denise M.; Ho, Caroline B.; Coan, Kristin; Abraham, Robert T.; Shokat, Kevan M. Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 17 p. 4749 - 4759

27292-49-5

404009-40-1

Precursor 3
70362-07-1 917-54-4 27292-49-5
DownStream 0

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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