Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2-(diaminomethylideneamino)ethylsulfanylmethanimidamide dihydrobromide
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Purity: 98.0%
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100130-32-3

100130-32-3 structure

Name: VUF8430 dihydrobromide
Chemical Name: 2-[(Aminoiminomethyl)amino]ethyl carbamimidothioic acid ester S-(2-guanidylethyl)-isothiourea
CAS Number: 100130-32-3
Molecular Formula: C₄H₁₃Br₂N₅S
Molecular Weight: 323.05300
Catalog: Signaling Pathways GPCR/G Protein Histamine Receptor
Create Date: 2017-06-17 19:11:52
Modify Date: 2025-08-25 11:14:21
VUF 8430 (dihydrobromide) is a potent and selective histamine H4 receptor agonist with a Ki of 31.6 nM and an EC50 of 50 nM[1].

Name	2-[(Aminoiminomethyl)amino]ethyl carbamimidothioic acid ester S-(2-guanidylethyl)-isothiourea
Synonyms	2-Carbamimidamidoethyl carbamimidothioate dihydrobromide

Description	VUF 8430 (dihydrobromide) is a potent and selective histamine H4 receptor agonist with a Ki of 31.6 nM and an EC50 of 50 nM[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Histamine Receptor
References	[1]. Lim HD, et al. Discovery of S-(2-guanidylethyl)-isothiourea (VUF 8430) as a potent nonimidazole histamine H4 receptor agonist. J Med Chem. 2006 Nov 16;49(23):6650-1.

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: RAREAE Radiation Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1954- Volume(issue)/page/year: 7,22,1957

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
RIDADR	NONH for all modes of transport
RTECS	UM6960000