VUF8430 dihydrobromide

Modify Date: 2024-01-01 20:11:06

VUF8430 dihydrobromide Structure
VUF8430 dihydrobromide structure
Common Name VUF8430 dihydrobromide
CAS Number 100130-32-3 Molecular Weight 323.05300
Density N/A Boiling Point 348.8ºC at 760 mmHg
Molecular Formula C4H13Br2N5S Melting Point N/A
MSDS Chinese USA Flash Point 164.8ºC
Symbol GHS07
GHS07
Signal Word Warning

 Use of VUF8430 dihydrobromide


VUF 8430 (dihydrobromide) is a potent and selective histamine H4 receptor agonist with a Ki of 31.6 nM and an EC50 of 50 nM[1].

 Names

Name 2-[(Aminoiminomethyl)amino]ethyl carbamimidothioic acid ester S-(2-guanidylethyl)-isothiourea
Synonym More Synonyms

 VUF8430 dihydrobromide Biological Activity

Description VUF 8430 (dihydrobromide) is a potent and selective histamine H4 receptor agonist with a Ki of 31.6 nM and an EC50 of 50 nM[1].
Related Catalog
References

[1]. Lim HD, et al. Discovery of S-(2-guanidylethyl)-isothiourea (VUF 8430) as a potent nonimidazole histamine H4 receptor agonist. J Med Chem. 2006 Nov 16;49(23):6650-1. 

 Chemical & Physical Properties

Boiling Point 348.8ºC at 760 mmHg
Molecular Formula C4H13Br2N5S
Molecular Weight 323.05300
Flash Point 164.8ºC
Exact Mass 320.92600
PSA 137.07000
LogP 3.00330
Vapour Pressure 4.91E-05mmHg at 25°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UM6960000
CHEMICAL NAME :
Pseudourea, 2-(2-guanidinoethyl)-2-thio-, dihydrobromide
CAS REGISTRY NUMBER :
100130-32-3
LAST UPDATED :
198806
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C4-H11-N5-S.2Br-H
MOLECULAR WEIGHT :
323.10

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RAREAE Radiation Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1954- Volume(issue)/page/year: 7,22,1957

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
RIDADR NONH for all modes of transport
RTECS UM6960000

 Synonyms

2-Carbamimidamidoethyl carbamimidothioate dihydrobromide
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