Top Suppliers:I want be here



97938-30-2

97938-30-2 structure
97938-30-2 structure
  • Name: Sophoraflavanone G
  • Chemical Name: sophoraflavanone G
  • CAS Number: 97938-30-2
  • Molecular Formula: C25H28O6
  • Molecular Weight: 424.486
  • Catalog: Natural product Flavonoids
  • Create Date: 2019-01-01 23:21:08
  • Modify Date: 2025-08-22 18:32:56
  • Sophoraflavanone G (Kushenol F) is iaolated from Sophora flavescens and shows anti-tumor and anti-inflammatory properties.  Sophoraflavanone G (Kushenol F) induces MDA-MB-231 and HL-60 cells apoptosis through suppression of MAPK-related pathways[1][2].

Name sophoraflavanone G
Synonyms 4H-1-Benzopyran-4-one, 2-(2,4-dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-8-[(2R)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-, (2S)-
Sophoraflavanone G
(2S)-2-(2,4-Dihydroxyphenyl)-5,7-dihydroxy-8-[(2R)-2-isopropenyl-5-methyl-4-hexen-1-yl]-2,3-dihydro-4H-chromen-4-one
Kushenol F
Norkurarinone
Vexibinol
Nor-kurarinone
Description Sophoraflavanone G (Kushenol F) is iaolated from Sophora flavescens and shows anti-tumor and anti-inflammatory properties.  Sophoraflavanone G (Kushenol F) induces MDA-MB-231 and HL-60 cells apoptosis through suppression of MAPK-related pathways[1][2].
Related Catalog
Target

IC50: 29.7 μM (MDA-MB-231 cell)[1]

In Vitro Sophoraflavanone G (0 -100 μM; 24 hours) decreases the viability of the HL-60 cells in a dose-dependent manner[1]. Sophoraflavanone G (0 -100 μM; 24 hours) induces HL-60 cell apoptosis, activated caspase-3 and caspase-9, and downregulated Bcl-2 and Bcl-xL. It also upregulates Bax and released cytochrome c from the mitochondria into the cytoplasm, enabling apoptosis via the mitochondrially-mediated "intrinsic" pathway[1] Sophoraflavanone G (0 -40 μM; 24 hours) inhibits MDA-MB-231 cell viability in a concentration-dependent manner, with an IC50 value of 29.7 ± 5.2 μM[2]<.br>
References

[1]. Li ZY, et al. Sophoraflavanone G Induces Apoptosis in Human Leukemia Cells and Blocks MAPK Activation.Am J Chin Med. 2016;44(1):165-76.

[2]. Huang WC, et al. Sophoraflavanone G from Sophora flavescens induces apoptosis in triple-negative breast cancer cells.Phytomedicine. 2019 Aug;61:152852.

Density 1.3±0.1 g/cm3
Boiling Point 659.3±55.0 °C at 760 mmHg
Melting Point 173-175℃
Molecular Formula C25H28O6
Molecular Weight 424.486
Flash Point 224.8±25.0 °C
Exact Mass 424.188599
PSA 107.22000
LogP 6.52
Vapour Pressure 0.0±2.1 mmHg at 25°C
Index of Refraction 1.623
Storage condition 2-8℃
Hazard Codes Xi
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.