- BioBioPha
- China
- Product Name: N-Nornuciferine
- Price: ￥Inquiry/5mg
- Purity: 98.0%
- Stocking Period: 1 Day
- Contact: Xueping-Zheng
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: N-Nornuciferine
- Price: ￥4000.0/5mg
- Purity: 98.0%
- Stocking Period: 1 Day
- Contact: Liu jia
4846-19-9
4846-19-9 structure
- Name: N-Nornuciferine
- Chemical Name: N-Nornuciferine
- CAS Number: 4846-19-9
- Molecular Formula: C18H19NO2
- Molecular Weight: 281.349
- Catalog: Natural product Alkaloid
- Create Date: 2017-03-06 22:23:17
- Modify Date: 2024-01-02 18:34:17
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N-Nornuciferine is an aporphine alkaloid in lotus leaf that significantly inhibits CYP2D6 with IC50 and Ki of 3.76 and 2.34 μM, respectively.
| Name | N-Nornuciferine |
|---|---|
| Synonyms |
4H-Dibenzo[de,g]quinoline, 5,6,6a,7-tetrahydro-1,2-dimethoxy-, (6aR)-
(6aR)-1,2-Dimethoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline 6aβ-Noraporphine, 1,2-dimethoxy- 4H-Dibenzo[de,g]quinoline, 5,6,6a,7-tetrahydro-1,2-dimethoxy-, (R)- Nornu-ciferine Sanjoinine Ia |
| Description | N-Nornuciferine is an aporphine alkaloid in lotus leaf that significantly inhibits CYP2D6 with IC50 and Ki of 3.76 and 2.34 μM, respectively. |
|---|---|
| Related Catalog | |
| Target |
IC50: 3.76 μM (CYP2D6)[1] Ki: 2.34 μM (CYP2D6)[1] |
| In Vitro | The herb of lotus leaves is a commonly used traditional Chinese medicine with a wide range of pharmacological and physiological activities, particularly the reduction of the blood triglyceride and cholesterol levels. N-Nornuciferine strongly inhibits CYP2D6 activity but shows weak or no inhibition of the other four P450 isoenzymes (CYP2C19, CYP3A4, CYP2E1, CYP2C9). N-Nornuciferine competitively inhibits the CYP2D6-catalyzed dextromethorphan o-demethylation with apparent Ki values of 2.34 μM[1]. |
| Kinase Assay | For the determination of the inhibition constant Ki values, various final concentrations of the specific substrate dextromethorphan for CYP2D6 in the range of 1 to 10 mM and different concentrations of the N-Nornuciferine in the range of 0 to 25 mM are used. After preincubation for 10 min, the reactions are initiated by the addition of NADPH. Each incubation test is performed in triplicate. Thirty minutes after the incubation is initiated, the reaction is stopped by the addition of 100 mL of ice-cold acetonitrile containing 1 mg/mL propranolol (IS). The incubation mixtures are then centrifuged at 15,000g for 10 min at 4 °C. Ten-microliter aliquots of the supernatants are injected into an LC-MS/MS system[1]. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 446.4±45.0 °C at 760 mmHg |
| Melting Point | 128-129 ºC |
| Molecular Formula | C18H19NO2 |
| Molecular Weight | 281.349 |
| Flash Point | 182.8±18.2 °C |
| Exact Mass | 281.141571 |
| PSA | 30.49000 |
| LogP | 3.23 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Index of Refraction | 1.598 |
| Storage condition | 2-8℃ |