351490-26-1
351490-26-1 structure
- Name: SB-423557
- Chemical Name: sb-423557
- CAS Number: 351490-26-1
- Molecular Formula: C28H36N2O4
- Molecular Weight: 464.59600
- Catalog: Signaling Pathways GPCR/G Protein CaSR
- Create Date: 2016-09-30 07:05:07
- Modify Date: 2024-01-24 07:36:17
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SB-423557 is an orally active calcium-sensing receptor (CaR) antagonist (IC50=520 nM), precursor of SB-423562 (IC50=73 nM). SB-423557 is well tolerated in human and increases plasma concentrations of exogenous parathyroid hormone (PTH) and stimulates bone formation[1].
| Name | sb-423557 |
|---|
| Description | SB-423557 is an orally active calcium-sensing receptor (CaR) antagonist (IC50=520 nM), precursor of SB-423562 (IC50=73 nM). SB-423557 is well tolerated in human and increases plasma concentrations of exogenous parathyroid hormone (PTH) and stimulates bone formation[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 520 nM (Calcium-sensing receptor)[1] |
| In Vivo | SB-423557 (oral administration; 10, 30 or 100 μM/kg; once daily; 12 weeks) elicits transient increases in plasma concentrations of PTH, resulting in increased bone mass and strength in both vertebrae and long bones compared to that of OVX controls[1]. |
| References |
| Molecular Formula | C28H36N2O4 |
|---|---|
| Molecular Weight | 464.59600 |
| Exact Mass | 464.26800 |
| PSA | 91.58000 |
| LogP | 4.35788 |
| Precursor 0 | |
|---|---|
| DownStream 1 | |
