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479-92-5

479-92-5 structure

Name: propyphenazone
Chemical Name: propyphenazone
CAS Number: 479-92-5
Molecular Formula: C₁₄H₁₈N₂O
Molecular Weight: 230.305
Catalog: API Antipyretic analgesics Antipyretic and analgesic
Create Date: 2018-02-04 08:00:00
Modify Date: 2024-01-02 13:19:53
Propyphenazone is a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, Propyphenazone-based analogues as prodrugs and selective cyclooxygenase-2 inhibitors.Target：COX-2Propyphenazone is structurally related to aminophenazone it has been associated with severe blood dyscrasias. Propyphenazone is introduced for the treatment of rheumatic disorders.

Name	propyphenazone
Synonyms	ANTIBIOTICTPJ-B causyth 2,3-Dimethyl-1-phenyl-4-isopropylpyrazolone budirol PROPYLPHENAZONE MFCD00053368 arantil P 3H-Pyrazol-3-one, 1,2-dihydro-1,5-dimethyl-4-(1-methylethyl)-2-phenyl- Isopropylphenazone Isopropyrine Propyphenazon Isopropylantipyrine cibalgina 4-Isopropyl-2,3-dimethyl-1-phenyl-5-pyrazolone 1,2-Dihydro-1,5-dimethyl-4-(1-methylethyl)-2-phenyl-3H-pyrazol-3-one isopropylantipyrin EINECS 207-539-2 1,5-dimethyl-4-(1-methylethyl)-2-phenyl-1,2-dihydro-3H-pyrazol-3-one propyphenazone Isopyrine Isopropylantipyrinum Larodon Eufibron 4-Isopropyl-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one 4-Isopropylantipyrine Isopropchin

Description	Propyphenazone is a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, Propyphenazone-based analogues as prodrugs and selective cyclooxygenase-2 inhibitors.Target：COX-2Propyphenazone is structurally related to aminophenazone it has been associated with severe blood dyscrasias. Propyphenazone is introduced for the treatment of rheumatic disorders.
Related Catalog	Research Areas >> Inflammation/Immunology
Target	COX
References	[1]. Burdan F, et al. Formation of the knee joint after prenatal propyphenazone (isopropylantipyrine) administration. Cells Tissues Organs. 2002;171(2-3):145-51.

Density	1.1±0.1 g/cm3
Boiling Point	319.0±25.0 °C at 760 mmHg
Melting Point	102-105°C
Molecular Formula	C₁₄H₁₈N₂O
Molecular Weight	230.305
Flash Point	123.8±15.5 °C
Exact Mass	230.141907
PSA	26.93000
LogP	1.74
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.556
Storage condition	Refrigerator
Stability	Stable. Incompatible with strong oxidizing agents.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CD2800000

CHEMICAL NAME :: Antipyrine, 4-isopropyl-

CAS REGISTRY NUMBER :: 479-92-5

BEILSTEIN REFERENCE NO. :: 0204533

LAST UPDATED :: 199701

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C14-H18-N2-O

MOLECULAR WEIGHT :: 230.34

WISWESSER LINE NOTATION :: T5NNVJ A1 BR& DY1&1 E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 860 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 97,601,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 960 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,401,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 295 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 122,434,1959

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 61,205,1937

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 61,205,1937

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1050 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: SMWOAS Schweizerische Medizinische Wochenschrift. (Schwabe & Co., Steintorst 13, 4010 Basel, Switzerland) V.50- 1920- Volume(issue)/page/year: 84,351,1954

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Precautionary Statements	P301 + P312 + P330
Hazard Codes	Xn
Risk Phrases	R36/37/38
Safety Phrases	S26-S36/37/39
RIDADR	NONH for all modes of transport
RTECS	CD2800000
HS Code	2933110000

50993-68-5

77-78-1

479-92-5

Literature: Yakugaku Zasshi, , vol. 57, p. 953,958; dtsch. Ref. S. 269 Chem.Abstr., , p. 2533 DE558473 , ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 19, p. 1186

Precursor 2
50993-68-5 77-78-1
DownStream 8
881-05-0 38604-70-5 22123-18-8 298-12-4
1672-63-5 50871-97-1 89080-91-1 105798-28-5

HS Code	2933199090
Summary	2933199090. other compounds containing an unfused pyrazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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