Name | Ibotenic acid |
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Synonyms |
Ibotenic acid
5-Isoxazoleacetic acid, α-amino-2,3-dihydro-3-oxo- a-Amino-3-hydroxy-5-isoxazoleacetic Acid a-Amino-2,3-dihydro-3-oxo-5-isoxazoleacetic Acid Acide amino(3-oxo-2,3-dihydro-1,2-oxazol-5-yl)acétique Amino(3-oxo-2,3-dihydro-1,2-oxazol-5-yl)acetic acid MFCD00069294 Amino-(3-hydroxy-5-isoxazolyl)acetic acid 2-amino-2-(3-oxo-1,2-oxazol-5-yl)acetic acid |
Description | Ibotenic acid has agonist activity at both the N-methyl-D-aspartate (NMDA) and trans-ACPD or metabolotropic quisqualate (Qm) receptor sites. |
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Related Catalog | |
Target |
NMDA receptor[1] |
In Vitro | Ibotenic acid (Ibo) is capable of acting at both NMDA and trans-ACPD receptors in the CNS, although only activation of NMDA receptors is involved in Ibo neurotoxicity. Ibotenic acid is toxic to cortical neurons exposes for 5 min with an EC50=77.3±8 μM (n=5) as measured by release of lactate dehydrogenase to the culture media[1]. |
References |
Density | 1.7±0.1 g/cm3 |
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Boiling Point | 458.8±45.0 °C at 760 mmHg |
Melting Point | 141-147 °C |
Molecular Formula | C5H6N2O4 |
Molecular Weight | 158.112 |
Flash Point | 231.3±28.7 °C |
Exact Mass | 158.032761 |
PSA | 109.58000 |
LogP | -1.07 |
Vapour Pressure | 0.0±1.2 mmHg at 25°C |
Index of Refraction | 1.610 |
Storage condition | -20°C |
Symbol |
GHS06 |
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Signal Word | Danger |
Hazard Statements | H301 |
Precautionary Statements | P301 + P310 |
Personal Protective Equipment | Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges |
Hazard Codes | T: Toxic; |
Risk Phrases | R23/24/25 |
Safety Phrases | S45-S38-S36/37/39-S28A-S22 |
RIDADR | 1544 |
RTECS | NY2100000 |
Packaging Group | III |
Hazard Class | 6.1(b) |
~% 2552-55-8 |
Literature: Tetrahedron Letters, , p. 2081 - 2084 |
~% 2552-55-8 |
Literature: Tetrahedron Letters, , p. 2081 - 2084 |