Top Suppliers:I want be here



2552-55-8

2552-55-8 structure
2552-55-8 structure
  • Name: Ibotenic acid
  • Chemical Name: Ibotenic acid
  • CAS Number: 2552-55-8
  • Molecular Formula: C5H6N2O4
  • Molecular Weight: 158.112
  • Catalog: Biochemical Common amino acids and protein drugs
  • Create Date: 2018-07-13 18:03:12
  • Modify Date: 2024-01-06 13:38:16
  • Ibotenic acid has agonist activity at both the N-methyl-D-aspartate (NMDA) and trans-ACPD or metabolotropic quisqualate (Qm) receptor sites.

Name Ibotenic acid
Synonyms Ibotenic acid
5-Isoxazoleacetic acid, α-amino-2,3-dihydro-3-oxo-
a-Amino-3-hydroxy-5-isoxazoleacetic Acid
a-Amino-2,3-dihydro-3-oxo-5-isoxazoleacetic Acid
Acide amino(3-oxo-2,3-dihydro-1,2-oxazol-5-yl)acétique
Amino(3-oxo-2,3-dihydro-1,2-oxazol-5-yl)acetic acid
MFCD00069294
Amino-(3-hydroxy-5-isoxazolyl)acetic acid
2-amino-2-(3-oxo-1,2-oxazol-5-yl)acetic acid
Description Ibotenic acid has agonist activity at both the N-methyl-D-aspartate (NMDA) and trans-ACPD or metabolotropic quisqualate (Qm) receptor sites.
Related Catalog
Target

NMDA receptor[1]

In Vitro Ibotenic acid (Ibo) is capable of acting at both NMDA and trans-ACPD receptors in the CNS, although only activation of NMDA receptors is involved in Ibo neurotoxicity. Ibotenic acid is toxic to cortical neurons exposes for 5 min with an EC50=77.3±8 μM (n=5) as measured by release of lactate dehydrogenase to the culture media[1].
References

[1]. Zinkand WC, et al. Ibotenic acid mediates neurotoxicity and phosphoinositide hydrolysis by independent receptormechanisms. Mol Chem Neuropathol. 1992 Feb-Apr;16(1-2):1-10.

Density 1.7±0.1 g/cm3
Boiling Point 458.8±45.0 °C at 760 mmHg
Melting Point 141-147 °C
Molecular Formula C5H6N2O4
Molecular Weight 158.112
Flash Point 231.3±28.7 °C
Exact Mass 158.032761
PSA 109.58000
LogP -1.07
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.610
Storage condition -20°C
Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H301
Precautionary Statements P301 + P310
Personal Protective Equipment Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes T: Toxic;
Risk Phrases R23/24/25
Safety Phrases S45-S38-S36/37/39-S28A-S22
RIDADR 1544
RTECS NY2100000
Packaging Group III
Hazard Class 6.1(b)

~%

2552-55-8 structure

2552-55-8

Literature: Tetrahedron Letters, , p. 2081 - 2084

~%

2552-55-8 structure

2552-55-8

Literature: Tetrahedron Letters, , p. 2081 - 2084
Precursor  2

DownStream  0