Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 4-ethoxymethylene-2-phenyl-2-oxazolin-5-one
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Purity: 95.0%
Stocking Period: 10 Day
Contact: Huang

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 4-ethoxymethylene-2-phenyl-2-oxazolin-5-one
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

15646-46-5

15646-46-5 structure

Name: 4-ethoxymethylene-2-phenyl-2-oxazolin-5-one
Chemical Name: 4-(ethoxymethylene)-2-phenyloxazol-5-one
CAS Number: 15646-46-5
Molecular Formula: C₁₂H₁₁NO₃
Molecular Weight: 217.22
Catalog: analytical chemistry Standard Forensic and veterinary standards
Create Date: 2019-01-02 17:48:52
Modify Date: 2024-01-14 07:27:32
Oxazolone is a haptenizing agent that induces acute or chronic inflammation of the large intestine and is used to construct models of colitis. Oxazolone can cause Th1/Th2-dependent colitis with weight loss and diarrhea. Oxazolone-induced inflammation can be mitigated by neutralizing anti-IL-4 or anti-TNF-α antibodies or decoy IL-13R2-α-FC proteins[1].

Name	4-(ethoxymethylene)-2-phenyloxazol-5-one
Synonyms	4-Ethoxymethylene-2-phenyloxazolin-5-one EINECS 239-713-9 4-ETHOXYMETHYLENE-2-PHENYL-2-OXAZOLIN-5-ONE MFCD00003204 4-(ethoxymethylidene)-2-phenyl-1,3-oxazol-5-one

Description	Oxazolone is a haptenizing agent that induces acute or chronic inflammation of the large intestine and is used to construct models of colitis. Oxazolone can cause Th1/Th2-dependent colitis with weight loss and diarrhea. Oxazolone-induced inflammation can be mitigated by neutralizing anti-IL-4 or anti-TNF-α antibodies or decoy IL-13R2-α-FC proteins[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Interleukin Related Research Areas >> Inflammation/Immunology
Target	IL-4 IL-13 TNFR1
References	[1]. Weigmann B, et al. Oxazolone-Induced Colitis as a Model of Th2 Immune Responses in the Intestinal Mucosa. Methods Mol Biol. 2016;1422:253-61.

Density	1.18 g/cm3
Boiling Point	308.8ºC at 760 mmHg
Melting Point	94-96 °C (dec.)(lit.)
Molecular Formula	C₁₂H₁₁NO₃
Molecular Weight	217.22
Flash Point	136.8ºC
Exact Mass	217.07400
PSA	47.89000
LogP	1.30350
Vapour Pressure	0.000666mmHg at 25°C
Index of Refraction	1.561
Storage condition	2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RQ5786250

CHEMICAL NAME :: 2-Oxazolin-5-one, 4-ethoxymethylene-2-phenyl-

CAS REGISTRY NUMBER :: 15646-46-5

LAST UPDATED :: 198209

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C12-H11-N-O3

MOLECULAR WEIGHT :: 217.24

WISWESSER LINE NOTATION :: T5NYVOJ BU1O2 ER

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#06780

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H317
Precautionary Statements	P280
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xn: Harmful;
Risk Phrases	R43
Safety Phrases	S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	RQ5786250
HS Code	2934999090

495-69-2

122-51-0

~67%

15646-46-5

Literature: Tikdari, Ahmad Momeni; Hamidian, Hooshang; Razee, Saeid Phosphorus, Sulfur and Silicon and the Related Elements, 2002 , vol. 177, # 12 p. 2821 - 2826

719302-55-3

15646-46-5

Literature: Chem. Penicillin, , S. 688, 808 Zhurnal Obshchei Khimii, , vol. 21, p. 562 Chem.Abstr., , # 8513

120165-75-5

15646-46-5

Literature: Zhurnal Obshchei Khimii, , vol. 22, p. 874,878; engl. Ausg. S. 935, 937

495-69-2

122-51-0

123-54-6

~42%

15646-46-5

Literature: Kepe, Vladimir; Kocevar, Marijan; Polanc, Solvenko; Vercek, Bojan; Tisler, Miha Tetrahedron, 1990 , vol. 46, # 6 p. 2081 - 2088

345894-39-5

15646-46-5

Literature: J. Penicillin TokyoChem.Abstr., , vol. 1, p. 383 J. Penicillin TokyoChem.Abstr., , p. 2618

495-69-2

15646-46-5

Literature: J. Penicillin TokyoChem.Abstr., , vol. 1, p. 383 J. Penicillin TokyoChem.Abstr., , p. 2618

495-69-2

109-94-4

15646-46-5

Literature: Chemische Berichte, , vol. 96, p. 377 - 380

Precursor 7
495-69-2 122-51-0 719302-55-3 120165-75-5
123-54-6 345894-39-5 109-94-4
DownStream 8
103897-17-2 121242-80-6 3674-27-9 65037-88-9
81000-03-5 89363-85-9 92856-34-3 63232-11-1

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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