15646-46-5
15646-46-5 structure
- Name: 4-ethoxymethylene-2-phenyl-2-oxazolin-5-one
- Chemical Name: 4-(ethoxymethylene)-2-phenyloxazol-5-one
- CAS Number: 15646-46-5
- Molecular Formula: C12H11NO3
- Molecular Weight: 217.22
- Catalog: analytical chemistry Standard Forensic and veterinary standards
- Create Date: 2019-01-02 17:48:52
- Modify Date: 2025-08-25 21:35:47
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Oxazolone is a haptenizing agent that induces acute or chronic inflammation of the large intestine and is used to construct models of colitis. Oxazolone can cause Th1/Th2-dependent colitis with weight loss and diarrhea. Oxazolone-induced inflammation can be mitigated by neutralizing anti-IL-4 or anti-TNF-α antibodies or decoy IL-13R2-α-FC proteins[1].
| Name | 4-(ethoxymethylene)-2-phenyloxazol-5-one |
|---|---|
| Synonyms |
4-Ethoxymethylene-2-phenyloxazolin-5-one
EINECS 239-713-9 4-ETHOXYMETHYLENE-2-PHENYL-2-OXAZOLIN-5-ONE MFCD00003204 4-(ethoxymethylidene)-2-phenyl-1,3-oxazol-5-one |
| Description | Oxazolone is a haptenizing agent that induces acute or chronic inflammation of the large intestine and is used to construct models of colitis. Oxazolone can cause Th1/Th2-dependent colitis with weight loss and diarrhea. Oxazolone-induced inflammation can be mitigated by neutralizing anti-IL-4 or anti-TNF-α antibodies or decoy IL-13R2-α-FC proteins[1]. |
|---|---|
| Related Catalog | |
| Target |
IL-4 IL-13 TNFR1 |
| References |
| Density | 1.18 g/cm3 |
|---|---|
| Boiling Point | 308.8ºC at 760 mmHg |
| Melting Point | 94-96 °C (dec.)(lit.) |
| Molecular Formula | C12H11NO3 |
| Molecular Weight | 217.22 |
| Flash Point | 136.8ºC |
| Exact Mass | 217.07400 |
| PSA | 47.89000 |
| LogP | 1.30350 |
| Vapour Pressure | 0.000666mmHg at 25°C |
| Index of Refraction | 1.561 |
| Storage condition | 2-8°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H317 |
| Precautionary Statements | P280 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | R43 |
| Safety Phrases | S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | RQ5786250 |
| HS Code | 2934999090 |
|
~67%
15646-46-5 |
| Literature: Tikdari, Ahmad Momeni; Hamidian, Hooshang; Razee, Saeid Phosphorus, Sulfur and Silicon and the Related Elements, 2002 , vol. 177, # 12 p. 2821 - 2826 |
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15646-46-5 |
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Literature: Chem. Penicillin, |
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~%
15646-46-5 |
| Literature: Zhurnal Obshchei Khimii, , vol. 22, p. 874,878; engl. Ausg. S. 935, 937 |
|
~42%
15646-46-5 |
| Literature: Kepe, Vladimir; Kocevar, Marijan; Polanc, Solvenko; Vercek, Bojan; Tisler, Miha Tetrahedron, 1990 , vol. 46, # 6 p. 2081 - 2088 |
|
~%
15646-46-5 |
| Literature: J. Penicillin TokyoChem.Abstr., , vol. 1, p. 383 J. Penicillin TokyoChem.Abstr., , p. 2618 |
|
~%
15646-46-5 |
| Literature: J. Penicillin TokyoChem.Abstr., , vol. 1, p. 383 J. Penicillin TokyoChem.Abstr., , p. 2618 |
|
~%
15646-46-5 |
| Literature: Chemische Berichte, , vol. 96, p. 377 - 380 |
| Precursor 7 | |
|---|---|
| DownStream 8 | |
![2-[(5-oxo-2-phenyl-1,3-oxazol-4-ylidene)methylamino]acetic acid structure](https://image.chemsrc.com/caspic/034/3674-27-9.png)
![N-(4-oxopyrido[1,2-a]pyrimidin-3-yl)benzamide structure](https://image.chemsrc.com/caspic/349/81000-03-5.png)
| HS Code | 2934999090 |
|---|---|
| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |