4-ethoxymethylene-2-phenyl-2-oxazolin-5-one
4-ethoxymethylene-2-phenyl-2-oxazolin-5-one structure
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Common Name | 4-ethoxymethylene-2-phenyl-2-oxazolin-5-one | ||
|---|---|---|---|---|
| CAS Number | 15646-46-5 | Molecular Weight | 217.22 | |
| Density | 1.18 g/cm3 | Boiling Point | 308.8ºC at 760 mmHg | |
| Molecular Formula | C12H11NO3 | Melting Point | 94-96 °C (dec.)(lit.) | |
| MSDS | Chinese USA | Flash Point | 136.8ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of 4-ethoxymethylene-2-phenyl-2-oxazolin-5-oneOxazolone is a haptenizing agent that induces acute or chronic inflammation of the large intestine and is used to construct models of colitis. Oxazolone can cause Th1/Th2-dependent colitis with weight loss and diarrhea. Oxazolone-induced inflammation can be mitigated by neutralizing anti-IL-4 or anti-TNF-α antibodies or decoy IL-13R2-α-FC proteins[1]. |
| Name | 4-(ethoxymethylene)-2-phenyloxazol-5-one |
|---|---|
| Synonym | More Synonyms |
| Description | Oxazolone is a haptenizing agent that induces acute or chronic inflammation of the large intestine and is used to construct models of colitis. Oxazolone can cause Th1/Th2-dependent colitis with weight loss and diarrhea. Oxazolone-induced inflammation can be mitigated by neutralizing anti-IL-4 or anti-TNF-α antibodies or decoy IL-13R2-α-FC proteins[1]. |
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| Related Catalog | |
| Target |
IL-4 IL-13 TNFR1 |
| References |
| Density | 1.18 g/cm3 |
|---|---|
| Boiling Point | 308.8ºC at 760 mmHg |
| Melting Point | 94-96 °C (dec.)(lit.) |
| Molecular Formula | C12H11NO3 |
| Molecular Weight | 217.22 |
| Flash Point | 136.8ºC |
| Exact Mass | 217.07400 |
| PSA | 47.89000 |
| LogP | 1.30350 |
| Vapour Pressure | 0.000666mmHg at 25°C |
| Index of Refraction | 1.561 |
| InChIKey | SJHPCNCNNSSLPL-NTMALXAHSA-N |
| SMILES | CCOC=C1N=C(c2ccccc2)OC1=O |
| Storage condition | 2-8°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H317 |
| Precautionary Statements | P280 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | R43 |
| Safety Phrases | S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | RQ5786250 |
| HS Code | 2934999090 |
|
~67%
4-ethoxymethyle... CAS#:15646-46-5 |
| Literature: Tikdari, Ahmad Momeni; Hamidian, Hooshang; Razee, Saeid Phosphorus, Sulfur and Silicon and the Related Elements, 2002 , vol. 177, # 12 p. 2821 - 2826 |
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~%
4-ethoxymethyle... CAS#:15646-46-5 |
|
Literature: Chem. Penicillin, |
|
~%
4-ethoxymethyle... CAS#:15646-46-5 |
| Literature: Zhurnal Obshchei Khimii, , vol. 22, p. 874,878; engl. Ausg. S. 935, 937 |
|
~42%
4-ethoxymethyle... CAS#:15646-46-5 |
| Literature: Kepe, Vladimir; Kocevar, Marijan; Polanc, Solvenko; Vercek, Bojan; Tisler, Miha Tetrahedron, 1990 , vol. 46, # 6 p. 2081 - 2088 |
|
~%
4-ethoxymethyle... CAS#:15646-46-5 |
| Literature: J. Penicillin TokyoChem.Abstr., , vol. 1, p. 383 J. Penicillin TokyoChem.Abstr., , p. 2618 |
|
~%
4-ethoxymethyle... CAS#:15646-46-5 |
| Literature: J. Penicillin TokyoChem.Abstr., , vol. 1, p. 383 J. Penicillin TokyoChem.Abstr., , p. 2618 |
|
~%
4-ethoxymethyle... CAS#:15646-46-5 |
| Literature: Chemische Berichte, , vol. 96, p. 377 - 380 |
| Precursor 7 | |
|---|---|
| DownStream 8 | |
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CAS#:63232-11-1| HS Code | 2934999090 |
|---|---|
| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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| 4-Ethoxymethylene-2-phenyloxazolin-5-one |
| EINECS 239-713-9 |
| 4-ETHOXYMETHYLENE-2-PHENYL-2-OXAZOLIN-5-ONE |
| MFCD00003204 |
| 4-(ethoxymethylidene)-2-phenyl-1,3-oxazol-5-one |