ShangHai DC Chemicals Co.,Ltd
China
Product Name: 2-APB
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

DC Chemicals Limited
China
Product Name: 2-APB
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Borinic acid,B,B-diphenyl-, 2-aminoethyl ester
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

524-95-8

524-95-8 structure

Name: 2-Aminoethyl Diphenylborinate
Chemical Name: 2-Aminoethyl Diphenylborinate
CAS Number: 524-95-8
Molecular Formula: C₁₄H₁₆BNO
Molecular Weight: 225.094
Catalog: Chemical reagent Organic reagent Boric acid
Create Date: 2018-09-19 03:27:52
Modify Date: 2025-08-21 20:52:54
2-Aminoethyl diphenylborinate (2-APB) is a cell-permeable inhibitor of IP3R. 2-Aminoethyl diphenylborinate also inhibits the store-operated Ca2+ (SOC) channel and activates some TRP channels (V1, V2 and V3)[1][2][3].

Name	2-Aminoethyl Diphenylborinate
Synonyms	2-Aminoethoxydiphenylborane Borinic acid, B,B-diphenyl-, 2-aminoethyl ester Natural Product Reagent A 2-diphenylboranyloxyethanamine 2-Aminoethoxydiphenyl borate,2-APB,2-Aminoethyl diphenyl borate Diphenylborinic Acid Ethanolamine Ester EINECS 208-366-5 Diphenylborinic Acid 2-Aminoethyl Ester 2-Aminoethyldiphenylborinate 2-Aminoethyl diphenylborinate Borinic acid, diphenyl-, 2-aminoethyl ester (9CI) MFCD00014823 (2-Aminoethoxy)diphenylborane

Description	2-Aminoethyl diphenylborinate (2-APB) is a cell-permeable inhibitor of IP3R. 2-Aminoethyl diphenylborinate also inhibits the store-operated Ca2+ (SOC) channel and activates some TRP channels (V1, V2 and V3)[1][2][3].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Research Areas >> Infection
References	[1]. Ma S, et al. Effect of Wilforine on the Calcium Signaling Pathway in Mythimna separata Walker MyocytesUsing the Calcium Imaging Technique. J Agric Food Chem. 2019 Nov 27. [2]. Boyacı MG, et al. Effects of 2-Aminoethyl Diphenylborinate, a Modulator of Transient Receptor Potential and OraiChannels in Subarachnoid Hemorrhage: An Experimental Study. [3]. Takahashi K, et al. Molecular mechanism of 2-APB-induced Ca²⁺ influx in external acidification in PC12. Exp Cell Res. 2014 May 1;323(2):337-45.

Density	1.0±0.1 g/cm3
Boiling Point	325.3±34.0 °C at 760 mmHg
Melting Point	192-194 °C(lit.)
Molecular Formula	C₁₄H₁₆BNO
Molecular Weight	225.094
Flash Point	150.6±25.7 °C
Exact Mass	225.132492
PSA	35.25000
LogP	3.48
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.560
Storage condition	2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ED6150000

CHEMICAL NAME :: Borinic acid, O-(2-aminoethyl)diphenyl-

CAS REGISTRY NUMBER :: 524-95-8

BEILSTEIN REFERENCE NO. :: 2942273

LAST UPDATED :: 199709

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C14-H16-B-N-O

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#01899

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xn: Harmful;
Risk Phrases	R36/37/38
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	ED6150000
HS Code	2931900090

856622-73-6

60-29-7

141-43-5

524-95-8

Literature: Chevron Research and Technology Company Patent: US5091377 A1, 1992 ;

108-86-1

141-43-5

524-95-8

Literature: Chen, Xiaofeng; Ke, Haihua; Chen, Yao; Guan, Changwei; Zou, Gang Journal of Organic Chemistry, 2012 , vol. 77, # 17 p. 7572 - 7578

4426-21-5

141-43-5

~73%

2622-89-1

524-95-8

Literature: Dobrydneva, Yuliya; Abelt, Christopher J.; Dovel, Beth; Thadigiri, Celina M.; Williams, Roy L.; Blackmore, Peter F. Molecular Pharmacology, 2006 , vol. 69, # 1 p. 247 - 256

2622-89-1

141-43-5

524-95-8

Literature: Weidmann; Zimmerman Justus Liebigs Annalen der Chemie, 1958 , vol. 619, p. 28,33 Full Text Show Details Michailow; Wawer Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1957 , p. 989;engl.Ausg.S.1013 Full Text Show Details Povlock; Lippincott Journal of the American Chemical Society, 1958 , vol. 80, p. 5409

23147-97-9

141-43-5

524-95-8

Literature: Letsinger; Skoog Journal of the American Chemical Society, 1955 , vol. 77, p. 2491,2492,2494

15323-04-3

141-43-5

524-95-8

Literature: Letsinger; Remes Journal of the American Chemical Society, 1955 , vol. 77, p. 2489

960-71-4

141-43-5

524-95-8

Literature: Rondestvedt et al. Journal of Organic Chemistry, 1955 , vol. 20, p. 9,11

Precursor 9
856622-73-6 60-29-7 141-43-5 108-86-1
4426-21-5 2622-89-1 23147-97-9 15323-04-3
960-71-4
DownStream 8
4426-21-5 14587-79-2 11113-50-1 98-80-6
2622-89-1 5868-90-6 59911-25-0 61733-90-2

HS Code	2931900090
Summary	2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%

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