160003-66-7

160003-66-7 structure

Name: Iniparib (BSI-201)
Chemical Name: 4-Iodo-3-nitrobenzamide
CAS Number: 160003-66-7
Molecular Formula: C₇H₅IN₂O₃
Molecular Weight: 292.031
Catalog: Biochemical Inhibitor DNA damage PARP inhibitor
Create Date: 2018-05-01 08:00:00
Modify Date: 2024-01-03 16:05:42
Iniparib (BSI-201) is an irreversible inhibitor of PARP1, used in the research of triple negative breast cancer.

Name	4-Iodo-3-nitrobenzamide
Synonyms	Iniparib (BSI-201) 4-Iodo-3-nitrobenzamide Benzamide, 4-iodo-3-nitro- Iniparib BSI-201

Description	Iniparib (BSI-201) is an irreversible inhibitor of PARP1, used in the research of triple negative breast cancer.
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> PARP Signaling Pathways >> Epigenetics >> PARP Research Areas >> Cancer
Target	PARP1
In Vitro	Iniparib nonselectively modifies cysteine-containing proteins in tumor cells[1]. Iniparib (100 μM) weakly inhibits SSB repair, and the inhibition can be reversed by knockdown of PARP1[2]. Iniparib in combination with cisplatin is cytotoxic to Myc/MDA-231 with EMT changes[3].
Cell Assay	For nine day cell proliferation assay, MDA-MB-436 and MDA-MB-231 cells are plated at 2000 and 500 cells/well respectively in a 96-well plate and treated with veliparib, cmpd-A, cmpd-C, Iniparib or Iniparib-met at 0, 0.0001, 0.01,0.1, 1 or 10 μM for nine days. For five day cell proliferation assay, MDAMB-231 and MDA-MB-436 cells are plated at 1000 and 4000 cells/well respectively in a 96-well plate and treated with Iniparib or Iniparib-met at 0. 0.1, 0.3, 1, 3 or 10 μM in the presence of 0, 1.8, 3.75, or 7.5 µM BSO for 5 days. DLD1+/+ and DLD1-/- cells are plated at 1000 cells/well in a 96-well plate and treated with TMZ at 0, 0.003, 0.01, 0.03, 0.1, 0.3 or 1 mM in the presence of 0, 0.005, 0.05, 0.5, or 5 µM veliparib, or Iniparib for five days. After treatment, cell titer glow is carried out[1].
References	[1]. Liu X, et al. Iniparib nonselectively modifies cysteine-containing proteins in tumor cells and is not a bona fide PARP inhibitor. Clin Cancer Res. 2012 Jan 15;18(2):510-23. [2]. Ma W, et al. Differential effects of poly(ADP-ribose) polymerase inhibition on DNA break repair in human cells are revealed with Epstein-Barr virus. Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6590-5. [3]. Yin S, et al. Myc mediates cancer stem-like cells and EMT changes in triple negative breast cancers cells. PLoS One. 2017 Aug 17;12(8):e0183578.

Density	2.1±0.1 g/cm3
Boiling Point	344.8±32.0 °C at 760 mmHg
Molecular Formula	C₇H₅IN₂O₃
Molecular Weight	292.031
Flash Point	162.3±25.1 °C
Exact Mass	291.934479
PSA	88.91000
LogP	1.71
Appearance	white to beige
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.696
Storage condition	room temp
Water Solubility	DMSO: soluble5mg/mL, clear

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H319
Precautionary Statements	P305 + P351 + P338
Hazard Codes	Xn
Risk Phrases	22-36-43
Safety Phrases	26
RIDADR	NONH for all modes of transport
HS Code	2924299090

89976-27-2

~81%

160003-66-7

Literature: DIVI'S LABORATORIES LIMITED; Divi, Murali Krishna Prasad; Rao, Mysore Aswatha Narayana; Rajuri, Venkataramana Patent: US2013/172618 A1, 2013 ; Location in patent: Paragraph 0027; 0028 ;

1336-21-6

35674-27-2

~39%

160003-66-7

Literature: Octamer, Inc. Patent: US5877185 A1, 1999 ;

879-93-6

~54%

160003-66-7

Literature: Cant, Alastair A.; Bhalla, Rajiv; Pimlott, Sally L.; Sutherland, Andrew Chemical Communications, 2012 , vol. 48, # 33 p. 3993 - 3995

35674-27-2

160003-66-7

Literature: Journal of Organic Chemistry, , vol. 62, # 10 p. 3093 - 3097

Precursor 4
89976-27-2 1336-21-6 35674-27-2 879-93-6
DownStream 0

HS Code	2924299090
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

160003-66-7	81-54-9
78-62-6	60800-55-7
77-47-4	87-85-4
77-86-1	78-44-4
12219-29-3	69680-01-9