Iniparib (BSI-201)

Modify Date: 2024-01-03 16:05:42

Iniparib (BSI-201) structure	Common Name	Iniparib (BSI-201)
	CAS Number	160003-66-7	Molecular Weight	292.031
	Density	2.1±0.1 g/cm3	Boiling Point	344.8±32.0 °C at 760 mmHg
	Molecular Formula	C₇H₅IN₂O₃	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	162.3±25.1 °C
	Symbol	GHS07	Signal Word	Warning

Use of Iniparib (BSI-201)

Iniparib (BSI-201) is an irreversible inhibitor of PARP1, used in the research of triple negative breast cancer.

Name	4-Iodo-3-nitrobenzamide
Synonym	More Synonyms

Description	Iniparib (BSI-201) is an irreversible inhibitor of PARP1, used in the research of triple negative breast cancer.
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> PARP Signaling Pathways >> Epigenetics >> PARP Research Areas >> Cancer
Target	PARP1
In Vitro	Iniparib nonselectively modifies cysteine-containing proteins in tumor cells[1]. Iniparib (100 μM) weakly inhibits SSB repair, and the inhibition can be reversed by knockdown of PARP1[2]. Iniparib in combination with cisplatin is cytotoxic to Myc/MDA-231 with EMT changes[3].
Cell Assay	For nine day cell proliferation assay, MDA-MB-436 and MDA-MB-231 cells are plated at 2000 and 500 cells/well respectively in a 96-well plate and treated with veliparib, cmpd-A, cmpd-C, Iniparib or Iniparib-met at 0, 0.0001, 0.01,0.1, 1 or 10 μM for nine days. For five day cell proliferation assay, MDAMB-231 and MDA-MB-436 cells are plated at 1000 and 4000 cells/well respectively in a 96-well plate and treated with Iniparib or Iniparib-met at 0. 0.1, 0.3, 1, 3 or 10 μM in the presence of 0, 1.8, 3.75, or 7.5 µM BSO for 5 days. DLD1+/+ and DLD1-/- cells are plated at 1000 cells/well in a 96-well plate and treated with TMZ at 0, 0.003, 0.01, 0.03, 0.1, 0.3 or 1 mM in the presence of 0, 0.005, 0.05, 0.5, or 5 µM veliparib, or Iniparib for five days. After treatment, cell titer glow is carried out[1].
References	[1]. Liu X, et al. Iniparib nonselectively modifies cysteine-containing proteins in tumor cells and is not a bona fide PARP inhibitor. Clin Cancer Res. 2012 Jan 15;18(2):510-23. [2]. Ma W, et al. Differential effects of poly(ADP-ribose) polymerase inhibition on DNA break repair in human cells are revealed with Epstein-Barr virus. Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6590-5. [3]. Yin S, et al. Myc mediates cancer stem-like cells and EMT changes in triple negative breast cancers cells. PLoS One. 2017 Aug 17;12(8):e0183578.

Density	2.1±0.1 g/cm3
Boiling Point	344.8±32.0 °C at 760 mmHg
Molecular Formula	C₇H₅IN₂O₃
Molecular Weight	292.031
Flash Point	162.3±25.1 °C
Exact Mass	291.934479
PSA	88.91000
LogP	1.71
Appearance of Characters	white to beige
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.696
Storage condition	room temp
Water Solubility	DMSO: soluble5mg/mL, clear

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H319
Precautionary Statements	P305 + P351 + P338
Hazard Codes	Xn
Risk Phrases	22-36-43
Safety Phrases	26
RIDADR	NONH for all modes of transport
HS Code	2924299090

Methyl 4-iodo-3...

CAS#:89976-27-2

~81%

Iniparib (BSI-201)

CAS#:160003-66-7

Literature: DIVI'S LABORATORIES LIMITED; Divi, Murali Krishna Prasad; Rao, Mysore Aswatha Narayana; Rajuri, Venkataramana Patent: US2013/172618 A1, 2013 ; Location in patent: Paragraph 0027; 0028 ;

Aqueous ammonia

CAS#:1336-21-6

4-Iodo-3-nitrob...

CAS#:35674-27-2

~39%

Iniparib (BSI-201)

CAS#:160003-66-7

Literature: Octamer, Inc. Patent: US5877185 A1, 1999 ;

4-Bromo-3-nitro...

CAS#:879-93-6

~54%

Iniparib (BSI-201)

CAS#:160003-66-7

Literature: Cant, Alastair A.; Bhalla, Rajiv; Pimlott, Sally L.; Sutherland, Andrew Chemical Communications, 2012 , vol. 48, # 33 p. 3993 - 3995

4-Iodo-3-nitrob...

CAS#:35674-27-2

Iniparib (BSI-201)

CAS#:160003-66-7

Literature: Journal of Organic Chemistry, , vol. 62, # 10 p. 3093 - 3097

Precursor 4
CAS#:89976-27-2 Methyl 4-iodo-3... CAS#:1336-21-6 Aqueous ammonia CAS#:35674-27-2 4-Iodo-3-nitrob... CAS#:879-93-6 4-Bromo-3-nitro...
DownStream 0

HS Code	2924299090
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Iniparib (BSI-201)

4-Iodo-3-nitrobenzamide

Benzamide, 4-iodo-3-nitro-

Iniparib

BSI-201

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Iniparib (BSI-201)
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Iniparib (BSI-201)
Price: ￥1526.0/25mg ￥2436.0/50mg ￥6326.0/250mg ￥676.0/10mg
Purity: 98.0%
Delivery: 2 Day
Contact: Liu jia
Email: 2130147988@qq.com

DC Chemicals Limited
China
Product Name: BSI-201
Price: $400.0/100mg $800.0/250mg $1600.0/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: BSI-201
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 4-Iodo-3-nitrobenzamide
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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Price: ￥522.6/10mg

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Iniparib (BSI-201)

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