1018674-83-3

1018674-83-3 structure

Name: FMK13918
Chemical Name: N-[2-(6-{[(3,4-dichloro-phenyl)methyl]amino}-2-(4-methoxyphenyl)-3-oxo-4-hydropyridino[2,3-b]pyrazin-4-yl)ethyl]acetamide
CAS Number: 1018674-83-3
Molecular Formula: C₂₅H₂₃Cl₂N₅O₃
Molecular Weight: 512.38800
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2016-04-05 17:38:22
Modify Date: 2024-01-05 10:59:53
CVT-11127 is a potent SCD inhibitor. CVT-11127 induces apoposis and arrests the cell cycle at the G1/S phase. CVT-11127 has the potential for the research of lung cancer[1].

Name	N-[2-(6-{[(3,4-dichloro-phenyl)methyl]amino}-2-(4-methoxyphenyl)-3-oxo-4-hydropyridino[2,3-b]pyrazin-4-yl)ethyl]acetamide
Synonyms	N-[2-[6-[[(3,4-Dichlorophenyl)methyl]amino]-2-(4-methoxyphenyl)-3-oxopyrido[2,3-b]pyrazin-4(3H)-yl]ethyl]-acetamide FMK13918

Description	CVT-11127 is a potent SCD inhibitor. CVT-11127 induces apoposis and arrests the cell cycle at the G1/S phase. CVT-11127 has the potential for the research of lung cancer[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Stearoyl-CoA Desaturase (SCD)
Target	SCD[1]
In Vitro	CVT-11127 (1 µM, 48 h) shows antiproliferation activity in H460 cells[1]. CVT-11127 (1 µM, 48 h) decreases the the population of cells in S-phase by 75%[1]. CVT-11127 (1 µM, 48 h) induces apoposis in H460 cells[1]. CVT-11127 (1, 2 µM) inhibitors the SCD (stearoylCoA desaturase) activity in H460 cells[1]. Cell Proliferation Assay[1] Cell Line: H460 cells Concentration: 1 µM Incubation Time: 48 h Result: Showed antiproliferation activity. Cell Cycle Analysis[1] Cell Line: H460 cells Concentration: 1 µM Incubation Time: 48 h Result: Decreased the the population of cells in S-phase by 75%. Apoptosis Analysis[1] Cell Line: H460 cells Concentration: 1 µM Incubation Time: 24 h Result: Induced apoposis H460 cells.
References	[1]. Hess D,et al. Inhibition of stearoylCoA desaturase activity blocks cell cycle progression and induces programmed cell death in lung cancer cells. PLoS One. 2010; 5(6):e11394.

Hazard Codes	Xn