FMK13918
Modify Date: 2024-01-05 10:59:53
FMK13918 structure
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Common Name | FMK13918 | ||
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| CAS Number | 1018674-83-3 | Molecular Weight | 512.38800 | |
| Density | 1.39±0.1 g/cm3(Predicted) | Boiling Point | N/A | |
| Molecular Formula | C25H23Cl2N5O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of FMK13918CVT-11127 is a potent SCD inhibitor. CVT-11127 induces apoposis and arrests the cell cycle at the G1/S phase. CVT-11127 has the potential for the research of lung cancer[1]. |
| Name | N-[2-(6-{[(3,4-dichloro-phenyl)methyl]amino}-2-(4-methoxyphenyl)-3-oxo-4-hydropyridino[2,3-b]pyrazin-4-yl)ethyl]acetamide |
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| Synonym | More Synonyms |
| Description | CVT-11127 is a potent SCD inhibitor. CVT-11127 induces apoposis and arrests the cell cycle at the G1/S phase. CVT-11127 has the potential for the research of lung cancer[1]. |
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| Related Catalog | |
| Target |
SCD[1] |
| In Vitro | CVT-11127 (1 µM, 48 h) shows antiproliferation activity in H460 cells[1]. CVT-11127 (1 µM, 48 h) decreases the the population of cells in S-phase by 75%[1]. CVT-11127 (1 µM, 48 h) induces apoposis in H460 cells[1]. CVT-11127 (1, 2 µM) inhibitors the SCD (stearoylCoA desaturase) activity in H460 cells[1]. Cell Proliferation Assay[1] Cell Line: H460 cells Concentration: 1 µM Incubation Time: 48 h Result: Showed antiproliferation activity. Cell Cycle Analysis[1] Cell Line: H460 cells Concentration: 1 µM Incubation Time: 48 h Result: Decreased the the population of cells in S-phase by 75%. Apoptosis Analysis[1] Cell Line: H460 cells Concentration: 1 µM Incubation Time: 24 h Result: Induced apoposis H460 cells. |
| References |
| Density | 1.39±0.1 g/cm3(Predicted) |
|---|---|
| Molecular Formula | C25H23Cl2N5O3 |
| Molecular Weight | 512.38800 |
| Exact Mass | 511.11800 |
| PSA | 98.14000 |
| LogP | 4.98600 |
| Storage condition | -20°C |
| Hazard Codes | Xn |
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| N-[2-[6-[[(3,4-Dichlorophenyl)methyl]amino]-2-(4-methoxyphenyl)-3-oxopyrido[2,3-b]pyrazin-4(3H)-yl]ethyl]-acetamide |
| FMK13918 |