28325-56-6

28325-56-6 structure

Name: IVHD-valtrate
Chemical Name: ((1S,4aR,6S,7R,7aS)-6-acetoxy-4a-hydroxy-1-((3-methylbutanoyl)oxy)-4a,5,6,7a-tetrahydro-1H-spiro[cyclopenta[c]pyran-7,2'-oxiran]-4-yl)methyl 3-methyl-2-((3-methylbutanoyl)oxy)butanoate
CAS Number: 28325-56-6
Molecular Formula: C₂₇H₄₀O₁₁
Molecular Weight: 540.600
Catalog: Natural product Iridoid derivative
Create Date: 2016-05-16 06:10:53
Modify Date: 2024-01-02 19:48:19
IVHD-valtrate, an active Valeriana jatamansi derivative, is against human ovarian cancer cells in vitro and in vivo. IVHD-valtrate induces cancer cells apoptosis and arrests the ovarian cancer cells in the G2/M phase. IVHD-valtrate has the potential to be a novel chemotherapeutic agent for the human ovarian cancer research[1].

Name	((1S,4aR,6S,7R,7aS)-6-acetoxy-4a-hydroxy-1-((3-methylbutanoyl)oxy)-4a,5,6,7a-tetrahydro-1H-spiro[cyclopenta[c]pyran-7,2'-oxiran]-4-yl)methyl 3-methyl-2-((3-methylbutanoyl)oxy)butanoate
Synonyms	Butanoic acid, 3-methyl-2-(3-methyl-1-oxobutoxy)-, [6-(acetyloxy)-4a,5,6,7a-tetrahydro-4a-hydroxy-1-(3-methyl-1-oxobutoxy)spiro[cyclopenta[c]pyran-7(1H),2'-oxiran]-4-yl]methyl ester {6-Acetoxy-4a-hydroxy-1-[(3-methylbutanoyl)oxy]-4a,5,6,7a-tetrahydro-1H-spiro[cyclopenta[c]pyran-7,2'-oxiran]-4-yl}methyl 3-methyl-2-[(3-methylbutanoyl)oxy]butanoate

Description	IVHD-valtrate, an active Valeriana jatamansi derivative, is against human ovarian cancer cells in vitro and in vivo. IVHD-valtrate induces cancer cells apoptosis and arrests the ovarian cancer cells in the G2/M phase. IVHD-valtrate has the potential to be a novel chemotherapeutic agent for the human ovarian cancer research[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
Target	IC50: apoptosis[1]
In Vitro	IVHD-valtrate inhibits the growth and proliferation of the A2780 and OVCAR-3 ovarian cancer cell lines in a concentration-dependent manner[1]. IVHD-valtrate results in a relatively low cytotoxicity to immortalized non-tumorigenic human ovarian surface epithelial cells (IOSE-144)[1].
References	[1]. Xiaoguang Li, et al. Valeriana jatamansi constituent IVHD-valtrate as a novel therapeutic agent to human ovarian cancer: in vitro and in vivo activities and mechanisms. Curr Cancer Drug Targets. 2013 May;13(4):472-83.

Hazard Codes	Xi