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514-78-3 58626-46-3
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514-78-3

514-78-3 structure
514-78-3 structure
  • Name: Canthaxanthin
  • Chemical Name: canthaxanthin
  • CAS Number: 514-78-3
  • Molecular Formula: C40H52O2
  • Molecular Weight: 564.840
  • Catalog: Food additive Color protection agent
  • Create Date: 2018-03-12 08:00:00
  • Modify Date: 2024-01-03 17:18:22
  • Canthaxanthin is a red-orange carotenoid with various biological activities, such as antioxidant, antitumor properties.
Name canthaxanthin
Synonyms MFCD00016364
β,β-Carotene-4,4'-dione, (7cis,9cis,11cis,13cis)-
(7cis,9cis,11cis,13cis)-β,β-Carotene-4,4'-dione
Canthaxanthin
all-trans-Canthaxanthin
EINECS 208-187-2
Description Canthaxanthin is a red-orange carotenoid with various biological activities, such as antioxidant, antitumor properties.
Related Catalog
In Vitro Canthaxanthin enrichment of LDL has the potential to protect cholesterol from oxidation. In addition to its free radical scavenging and antioxidant properties (e.g., the induction of catalase and superoxide dismutase), canthaxanthin shows immunomodulatory activity (e.g. enhancing the proliferation and function of immune competent cells) and plays important role in gap junction communication (e.g. induction of the transmembrane protein connexin)[1]. At concentrations of 0.1 to 1 x 1000 μM, canthaxanthin significantly reduces the overall number of tumor cells. The greatest inhibition is observed at a canthaxanthin concentration of 1000 after 72 h and 96 h of incubation[2].
In Vivo Canthaxanthin alters the protective ability of tissues against oxidative stress. Canthaxanthin treatment for 15 d at the dose of 14 μg/kg body weight results in hepatic incorporation of the carotenoid, which is maximum in liver and reaches 0.52 ± 0.05 nmol/g liver. Glutathione peroxidase activity is 35% lower and catalase (59%) and manganese superoxide dismutase (28%) activities are higher in canthaxanthin-treated mice than in controls[3]. Canthaxanthin inhibit the growth of mammary tumors in mice and the anti-tumor activity is also influenced by the supplemental dose[4]. Diet supplementation with canthaxanthin for 3 weeks prior to the carcinogen results in a 65% reduction in the number of mammary cancers by a mechanism not involving pro-vitamin A activity[5].
Animal Admin Mice: Female 6-wk-old Balb/c mice are randomly divided into two groups (n = 10/group). The control group receives olive oil alone (vehicle) and the canthaxanthin-treated group receives canthaxanthin at a dose of 14 μg/kg body weight per day. At the end of the treatment, mice are killed by cervical dislocation and liver is excised, frozen in liquid nitrogen and stored at −80°C[3].
References

[1]. Esatbeyoglu T, et al. Canthaxanthin: From molecule to function. Mol Nutr Food Res. 2017 Jun;61(6).

[2]. Huang DS, et al. Inhibitory effects of canthaxanthin on in vitro growth of murine tumor cells. Cancer Lett. 1992 Aug 31;65(3):209-13.

[3]. Palozza P, et al. Canthaxanthin supplementation alters antioxidant enzymes and iron concentration in liver of Balb/c mice. J Nutr. 2000 May;130(5):1303-8.

[4]. Chew BP, et al. A comparison of the anticancer activities of dietary beta-carotene, canthaxanthin and astaxanthin in mice in vivo. Anticancer Res. 1999 May-Jun;19(3A):1849-53.

[5]. Grubbs CJ, et al. Effect of canthaxanthin on chemically induced mammary carcinogenesis. Oncology. 1991;48(3):239-45.
Density 1.0±0.1 g/cm3
Boiling Point 717.0±40.0 °C at 760 mmHg
Molecular Formula C40H52O2
Molecular Weight 564.840
Flash Point 253.9±24.3 °C
Exact Mass 564.396729
PSA 34.14000
LogP 10.69
Vapour Pressure 0.0±2.3 mmHg at 25°C
Index of Refraction 1.575
Storage condition 0-6°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
FI0330000
CHEMICAL NAME :
beta-Carotene-4,4'-dione, all-trans-
CAS REGISTRY NUMBER :
514-78-3
BEILSTEIN REFERENCE NO. :
1898520
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C40-H52-O2
MOLECULAR WEIGHT :
564.92

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
86 mg/kg/15W-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - retinal changes (pigmentary depositions, retinitis, other)
REFERENCE :
MJAUAJ Medical Journal of Australia. (Australasian Medical Pub. Co. Ltd., 71-79 Arundel St., Glebe, N.S.W., Australia) V.1- 1914- Volume(issue)/page/year: 143,622,1985
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SCPHA4 Scientia Pharmaceutica. (Oesterreichische Apotheker-Verlagsgesellschaft MBH, Spitalgasse 31, 1094 Vienna 9, Austria) V.1- 1930- Volume(issue)/page/year: 47,39,1979
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Risk Phrases 25-36/37/38
Safety Phrases 45-36/37/39-28A-26
RIDADR UN 2811 6.1/PG 2
WGK Germany 3
RTECS GA0875000
Packaging Group II
Hazard Class 6.1
HS Code 3204199000
HS Code 3204199000

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