19767-45-4
19767-45-4 structure
- Name: MESNA
- Chemical Name: Mesna
- CAS Number: 19767-45-4
- Molecular Formula: C2H5NaO3S2
- Molecular Weight: 164.179
- Catalog: API Respiratory medication Peony
- Create Date: 2018-08-13 20:47:28
- Modify Date: 2026-06-30 16:02:21
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2-mercaptoethane sulfonate (Mesna), is a synthetic small molecule, widely used as a systemic protective agent against chemotherapy toxicity, but is primarily used to reduce hemorrhagic cystitis induced by cyclophosphamide.IC50 Value: 182 mM (decreased superoxide anion production stimulated with PMA (tetradecanoylphorbol acetate) in PMN in-vitro); 70mM (inhibited H2O2 production) [3]Target: in vitro: MESNA had no effect on the qualitative and quantitative characteristics of the indicated processes in both the types of the doxorubicin sensitive cells. The combined use of doxorubicin and phosphamide or cyclophosphane the use of MESNA for lowering the urotoxic action of oxazophosphorines had no effect on the biological efficacy of doxorubicin [4].in vivo: AMH-positive follicles were significantly decreased after cisplatin administration, which was significantly reversed when mesna was co-administered with cisplatin. The end product of lipid peroxidation, malondialdehyde (MDA), was significantly increased, but the anti-oxidative enzymatic activity of superoxide dismutase (SOD) and glutathione (GSH) were significantly decreased in cisplatin groups when compared with NS group. In contrast, after co-administration of cisplatin with mesna, MDA was significantly decreased whereas the activity of SOD and the concentration of GSH were increased. Moreover, mesna did not decrease the anti-tumor property of cisplatin in HePG2 cell lines [2]. After head trauma, tissue malondialdehyde levels increased; these levels were significantly decreased by MESNA administration. Caspase-3 levels were increased after trauma, but no effect of MESNA was determined in caspase-3 activity [1].Clinical trial: Effects of Mesna on Homocysteine in Kidney Failure . Phase2
| Name | Mesna |
|---|---|
| Synonyms |
SODIUM2-MERCAPTOETHANESULPHONATE
Mesna(sodium 2-mercaptoethanesulfonate) 2-Mercaptoethanesulfonic acid monosodium salt 2-mercaptoethanesulphonic acid sodium salt 2-Mercaptoethanesulfonic acid sodium salt,Coenzyme M sodium salt,HS-CoM Na Mesna(FDA) SODIUM 2-MERCAPTOETHANESULFONATE Mesna(UroMitexan, Mesnex) Ethanesulfonic acid, 2-mercapto-, sodium salt (1:1) Sodium 2-sulfanylethanesulfonate 2-MERCAPTOETHANESULPHONIC ACID SODIUM SALT mesnum mesnaum MERCAPTOETHANESULFONIC ACID SODIUM SALT 2-mercapto-ethanesulfonicacimonosodiumsalt MFCD00007535 2-mercaptoethanesulphonate COENZYME M 2-Mercaptoethane sulfonate sodium Sodium mercaptoethanesulfonate SODIUM 2-MERCAPTOETHANESULFONATE FOR SYN 2-Mercaptoethanesulfonic-d4-acid sodiuM salt (MESNA-d4) EINECS 243-285-9 Mistabronco 2-Mercaptoethanesulfonic Acid Sodium Salt 2-mercaptoethanesulfonicacidmonosodiumsalt Uromitexan 2- Mercaptothanesulfonic Acid Sodium Salt The dtment of sodium Mesnex SODIUMMERCAPTOETHANESULPHONATE uromitexan 2-Mercaptoethanesulfonic,Mesna 2-MERCAPTOETHANESULPHONATE,SODIUMSALT 2-MERCAPTOETHANESULFONIC ACID SODIUM Sodium2-Mercaptoethanesulfonate> MESNEX mitexan Mesnum MESNA(2-MERCAPTOETHANESULFONICACIDSODIUMSALT) 2-Mercaptoethanesulfonic acid sodium salt, Coenzyme M sodium salt, HS-CoM Na, MESNA 2-MERCAPTOETHANESULFONIC ACID SODIUM SALT mistabron BETA-MERCAPTOETHANESULPHONICACIDSODIUMSALT 2-(acetylthio)ethanesulfonic acid HS-COM NA 2-Mercaptoethanesulfonic Acid Sodium Salt Mesna coenzyme M sodium salt sodium mercaptoethanesulfonate MESNA (2-Mercaptoethanesulfonate sodiuM) MESNA SODIUM SALT Sodium 2-mercaptoethanesulfonate Mesna:Sodium 2-mercaptoethanesulphonate Mesna //BP sodium 2-Mercapto-ethanesulfonate Mesina Ethanesulfonic acid, 2-mercapto-, monosodium salt Mesna5 UNII-NR7O1405Q9 2-Mercapto-1-ethanesulfonic Acid Monosodium Salt 2-mercaptoethanesulfonic COENZYME M SODIUM SALT mucofluid 2-MERCAPTOETHANESULFONIC ACID SODIUM SALT 5 Mesna API SodiuM 2-Mercaptoethanesulfonate (Mesna) 2-Mercaptoethanesulfonate, sodium Mesna Powder Standd sodiuM 1-sulfanyl-2-sulfoethyliuM |
| Description | 2-mercaptoethane sulfonate (Mesna), is a synthetic small molecule, widely used as a systemic protective agent against chemotherapy toxicity, but is primarily used to reduce hemorrhagic cystitis induced by cyclophosphamide.IC50 Value: 182 mM (decreased superoxide anion production stimulated with PMA (tetradecanoylphorbol acetate) in PMN in-vitro); 70mM (inhibited H2O2 production) [3]Target: in vitro: MESNA had no effect on the qualitative and quantitative characteristics of the indicated processes in both the types of the doxorubicin sensitive cells. The combined use of doxorubicin and phosphamide or cyclophosphane the use of MESNA for lowering the urotoxic action of oxazophosphorines had no effect on the biological efficacy of doxorubicin [4].in vivo: AMH-positive follicles were significantly decreased after cisplatin administration, which was significantly reversed when mesna was co-administered with cisplatin. The end product of lipid peroxidation, malondialdehyde (MDA), was significantly increased, but the anti-oxidative enzymatic activity of superoxide dismutase (SOD) and glutathione (GSH) were significantly decreased in cisplatin groups when compared with NS group. In contrast, after co-administration of cisplatin with mesna, MDA was significantly decreased whereas the activity of SOD and the concentration of GSH were increased. Moreover, mesna did not decrease the anti-tumor property of cisplatin in HePG2 cell lines [2]. After head trauma, tissue malondialdehyde levels increased; these levels were significantly decreased by MESNA administration. Caspase-3 levels were increased after trauma, but no effect of MESNA was determined in caspase-3 activity [1].Clinical trial: Effects of Mesna on Homocysteine in Kidney Failure . Phase2 |
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| Related Catalog | |
| References |
| Melting Point | >240°C dec. |
|---|---|
| Molecular Formula | C2H5NaO3S2 |
| Molecular Weight | 164.179 |
| Exact Mass | 163.957779 |
| PSA | 104.38000 |
| LogP | 0.54220 |
| Storage condition | -20?C Freezer, Under Inert Atmosphere |
| Stability | Stable. Incompatible with strong oxidizing agents. |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi:Irritant |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 2 |
| RTECS | KI7968000 |
| HS Code | 2930909090 |
|
~%
19767-45-4 |
| Literature: US2005/137419 A1, ; Page/Page column 4 ; |
| Precursor 1 | |
|---|---|
| DownStream 5 | |
| HS Code | 2930909090 |
|---|---|
| Summary | 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |