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11021-14-0

11021-14-0 structure

Name: Ginsenoside Rc
Chemical Name: ginsenoside Rc
CAS Number: 11021-14-0
Molecular Formula: C₅₃H₉₀O₂₂
Molecular Weight: 1079.269
Catalog: Biochemical Plant extracts
Create Date: 2018-05-15 08:00:00
Modify Date: 2024-01-02 17:30:57
Ginsenoside Rc, one of major Ginsenosides from Panax ginseng, enhances GABA receptorA (GABAA)-mediated ion channel currents (IGABA). Ginsenoside Rc inhibits the expression of TNF-α and IL-1β.

Name	ginsenoside Rc
Synonyms	EINECS 234-253-5 Ginsenoside Rc (3β,12β)-20-{[6-O-(α-L-Arabinofuranosyl)-β-D-glucopyranosyl]oxy}-12-hydroxydammar-24-en-3-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranoside β-D-Glucopyranoside, (3β,12β)-20-[(6-O-α-L-arabinofuranosyl-β-D-glucopyranosyl)oxy]-12-hydroxydammar-24-en-3-yl 2-O-β-D-glucopyranosyl- 20-((6-O-α-L-Arabinofuranosyl-β-D-glucopyranosyl)oxy)-12β-hydroxydammar-24-en-3β-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranoside MFCD00133368 Ginsenoside-Rc from Panax ginseng (Korean ginseng) root

Description	Ginsenoside Rc, one of major Ginsenosides from Panax ginseng, enhances GABA receptorA (GABAA)-mediated ion channel currents (IGABA). Ginsenoside Rc inhibits the expression of TNF-α and IL-1β.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Signaling Pathways >> Neuronal Signaling >> GABA Receptor Signaling Pathways >> Immunology/Inflammation >> Interleukin Related Signaling Pathways >> Apoptosis >> TNF Receptor Natural Products >> Terpenoids and Glycosides Research Areas >> Cancer Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
Target	GABA Receptor TNF-α IL-1β
In Vitro	Ginsenoside Rc, one of major Ginsenosides from Panax ginseng, enhances γ-aminobutyric acid (GABA) receptorA (GABAA)-mediated ion channel currents. Ginsenoside Rc enhances GABA-mediated ion currents in oocytes expressing the GABAA receptor[1]. Ginsenoside Rc significantly inhibits the expression of macrophage-derived cytokines, such as TNF-α and IL-1β. Ginsenoside Rc also markedly suppresses the activation of TANK-binding kinase 1/IκB kinase ε/interferon regulatory factor-3 and p38/ATF-2 signaling in activated RAW264.7 macrophages, human synovial cells, and HEK293 cells. Ginsenoside Rc exerts its anti-inflammatory actions by suppressing TANK-binding kinase 1/IκB kinase ε/interferon regulatory factor-3 and p38/ATF-2 signaling. Ginsenoside Rc suppresses the nuclear translocation of phospho-ATF-2 and phospho-FRA-1, whereas the translocation of p65 at its peak time points (30 and 60 min) is not decreased by Ginsenoside Rc treatment. Ginsenoside Rc regulates the expression of the proinflammatory cytokine TNF-α, which is produced by macrophages, by suppressing AP-1 activation[2].
Kinase Assay	To evaluate the effects of Ginsenoside Rc on kinase activity, immunoprecipitated TBK1, IKKε, and p38 are incubated in reaction buffer in the presence or absence of Ginsenoside Rc. The reactions are initiated by the addition of Mg-ATP. After a 30 min incubation at 30°C, the reactions are stopped by the addition of sample buffer and the samples are boiled. Kinase activity is assessed by immunoblotting with antibodies against the phospho-forms of IKKε, IRF-3, and ATF-2[2].
References	[1]. Lee BH, et al. Effects of Ginsenoside Metabolites on GABAA Receptor-Mediated Ion Currents. J Ginseng Res. 2012 Jan;36(1):55-60. [2]. Yu T, et al. Ginsenoside Rc from Panax ginseng exerts anti-inflammatory activity by targeting TANK-bindingkinase 1/interferon regulatory factor-3 and p38/ATF-2. J Ginseng Res. 2017 Apr;41(2):127-133.

Density	1.4±0.1 g/cm3
Boiling Point	1128.3±65.0 °C at 760 mmHg
Molecular Formula	C₅₃H₉₀O₂₂
Molecular Weight	1079.269
Flash Point	636.2±34.3 °C
Exact Mass	1078.592407
PSA	357.06000
LogP	5.10
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.622
Storage condition	2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LY9536300

CHEMICAL NAME :: Ginsenoside RC

CAS REGISTRY NUMBER :: 11021-14-0

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C53-H90-O22

MOLECULAR WEIGHT :: 1079.43

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 410 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TEST SYSTEM :: Rodent - rat

DOSE/DURATION :: 50 mg/kg

REFERENCE :: CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 24,2400,1976

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H312-H332
Precautionary Statements	P280
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful;
Risk Phrases	R20/21/22
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	LY9536300

88140-36-7

11021-14-0

Literature: Kitagawa; Taniyama; Yoshikawa; Ikenishi; Nakagawa Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 11 p. 2961 - 2970

88140-36-7

141-82-2

11021-14-0

Literature: Chemical and Pharmaceutical Bulletin, , vol. 37, # 11 p. 2961 - 2970

Precursor 1
88140-36-7
DownStream 0

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