Shanghai Nianxing Industrial Co., Ltd
China
Product Name: α-Cyano-4-hydroxycinnamic acid
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: α-Cyano-4-hydroxycinnamic acid
Price: ￥118.0/1g ￥1178.0/25g ￥338.0/5g
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

ShangHai DC Chemicals Co.,Ltd
China
Product Name: α-CHCA
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Lai

DC Chemicals Limited
China
Product Name: α-CHCA
Price: $750.0/100mg $1400.0/250mg $2600.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: alpha-Cyano-4-hydroxycinnamic acid
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

28166-41-8

28166-41-8 structure

Name: α-Cyano-4-hydroxycinnamic acid
Chemical Name: α-cyano-4-hydroxycinnamic acid
CAS Number: 28166-41-8
Molecular Formula: C₁₀H₇NO₃
Molecular Weight: 189.167
Catalog: Chemical reagent Organic reagent fatty acid
Create Date: 2019-02-18 00:33:42
Modify Date: 2024-01-02 12:27:22
α-Cyano-4-hydroxycinnamic acid (α-Cyano-4-hydroxycinnamate) is a potent and non-competitive inhibitor of monocarboxylate transporters (MCTs). α-Cyano-4-hydroxycinnamic acid inhibits mitochondrial pyruvate transporter with a Ki of 6.3 μM. α-Cyano-4-hydroxycinnamic acid is used as a matrix to facilitate peptide ionization in matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry applications[1][2].

Name	α-cyano-4-hydroxycinnamic acid
Synonyms	(2E)-2-Cyano-3-(4-hydroxyphenyl)acrylic acid Ganaxolone 2-Propenoic acid, 2-cyano-3-(4-hydroxyphenyl)-, (2E)- 4-HCCA α-cyano-4-hydroxycinnamic acid 2-Cyano-3-(4-hydroxyphenyl)acrylic Acid alpha-Cyano-4-hydroxycinnamic acid MFCD00004204 (2E)-2-cyano-3-(4-hydroxyphenyl)prop-2-enoic acid EINECS 248-879-1 A-CYANO-4-HYDROXYCINNAMIC ACID ACCA

Description	α-Cyano-4-hydroxycinnamic acid (α-Cyano-4-hydroxycinnamate) is a potent and non-competitive inhibitor of monocarboxylate transporters (MCTs). α-Cyano-4-hydroxycinnamic acid inhibits mitochondrial pyruvate transporter with a Ki of 6.3 μM. α-Cyano-4-hydroxycinnamic acid is used as a matrix to facilitate peptide ionization in matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry applications[1][2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Monocarboxylate Transporter Research Areas >> Metabolic Disease
In Vitro	α-Cyano-4-hydroxycinnamic acid (α-Cyano-4-hydroxycinnamate) inhibits monocarboxylates transport such as lactate and pyruvate[2]. α-Cyano-4-hydroxycinnamic acid (CHC; 0.5 mM and 1 mM) of 1 mM has a significant inhibitory effect on branching morphogenesis and decreases the epithelial perimeter and area of lung explants in a dose dependent way[2]. At 100 μM concentration, α-Cyano-4-hydroxycinnamic acid rapidly and almost totally inhibits O2 uptake by rat heart mitochondria oxidizing pyruvate. Inhibition can be detected at concentrations of inhibitor as low as 1 μM although inhibition took time to develop at this concentration. Inhibition can be reversed by diluting out the inhibitor[1].
References	[1]. A P Halestrap, et al. The mitochondrial pyruvate carrier. Kinetics and specificity for substrates and inhibitors. Biochem J. 1975 Apr; 148(1): 85-96. [2]. Sara Granja, et al. The Monocarboxylate Transporter Inhibitor α-cyano-4-hydroxycinnamic Acid Disrupts Rat Lung Branching. Cell Physiol Biochem. 2013;32(6):1845-56. [3]. Makoto Watanabe, et al. Improvement of Mass Spectrometry Analysis of Glycoproteins by MALDI-MS Using 3-aminoquinoline/α-cyano-4-hydroxycinnamic Acid. Anal Bioanal Chem. 2013 May;405(12):4289-93.

Density	1.4±0.1 g/cm3
Boiling Point	398.1±32.0 °C at 760 mmHg
Melting Point	245-250 °C(lit.)
Molecular Formula	C₁₀H₇NO₃
Molecular Weight	189.167
Flash Point	194.5±25.1 °C
Exact Mass	189.042587
PSA	81.32000
LogP	1.53
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.674
Storage condition	2-8°C
Water Solubility	methanol: 10 mg/mL, clear

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2926909090

HS Code	2926909090
Summary	HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

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