Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: (9E,11Z,13E)-9,11,13-octadecatrienoic acid
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Purity: 98.0%
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506-23-0

506-23-0 structure

Name: β-Eleostearic acid
Chemical Name: (E,Z,E)-octadeca-9,11,13-trienoic acid
CAS Number: 506-23-0
Molecular Formula: C₁₈H₃₀O₂
Molecular Weight: 278.430
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2016-07-13 03:08:02
Modify Date: 2024-02-03 19:06:38
α-Eleostearic acid (cis-Eleostearic acid), a conjugated linolenic acid, is an apoptosis inducer. α-Eleostearic acid is also a ferroptosis inducer. α-Eleostearic acid exhibits antioxidant and antitumor activity[1][2][3].

Name	(E,Z,E)-octadeca-9,11,13-trienoic acid
Synonyms	9Z,11E,13E-Octadecatrienoic Acid 9,11,13-Octadecatrienoic acid, (E,E,E)- (9E,11E,13E)-Octadeca-9,11,13-trienoic acid (E,E,E)-9,11,13-octadecatrienoic acid 9(Z),11(E),13(E)-OCTADECATRIENOIC ACID α-Eleostearic acid (9Z,11E,13E)-9,11,13-Octadecatrienoic acid (9Z,11E,13E)-octadeca-9,11,13-trienoic acid cis-9, trans-11, trans-13-octadecatrienoic acid 9-cis,11-trans,13-trans-octadecatrienoic acid (9E,11E,13E)-9,11,13-Octadecatrienoic acid (E,E,E)-octadeca-9,11,13-trienoic acid 9,11,13-Octadecatrienoic acid, (9E,11E,13E)- β-Eleostearic acid 9E,11E,13E-octadecatrienoic acid a-Eleostearic Acid 9,11,13-Octadecatrienoic acid, (9Z,11E,13E)- (9Z,11E,13E)-Octadecatrienoic acid trans-9, trans-11, trans-13-octadecatrienoic acid

Description	α-Eleostearic acid (cis-Eleostearic acid), a conjugated linolenic acid, is an apoptosis inducer. α-Eleostearic acid is also a ferroptosis inducer. α-Eleostearic acid exhibits antioxidant and antitumor activity[1][2][3].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Apoptosis >> Ferroptosis Research Areas >> Metabolic Disease
In Vitro	α-Eleostearic acid (0-40 μM; 24 h) 抑制一些癌细胞系和成纤维细胞系的生长，包括 HL60 细胞和 HT29 细胞[1]。 α-Eleostearic acid (20 μM; 6 h) 在 HL60 细胞中诱导典型的细胞凋亡现象：细胞和核碎裂，以及核小体 DNA 碎裂[1]。 α-Eleostearic acid (0.01-100 μM; 72 h) 触发 MDA-MB-231 细胞死亡，这种死亡被 Fer-1、Deferoxamine 和维生素 E 抑制[1]。
In Vivo	α-Eleostearic acid (0.5% of total lipid given; p.o.) 抑制 Sodium Arsenite 诱导的体内氧化应激：逆转抗氧化酶活性和降低脂质过氧化水平[2]。在侵袭性 TNBC 原位异种移植模型中，给小鼠口服天然富含 α-Eleostearic acid 的桐油可限制肿瘤生长和转移[3]。
References	[1]. Kobori M, et, al. Alpha-eleostearic acid and its dihydroxy derivative are major apoptosis-inducing components of bitter gourd. J Agric Food Chem. 2008 Nov 26;56(22):10515-20. [2]. Saha SS, et, al. Comparative study of antioxidant activity of alpha-eleostearic acid and punicic acid against oxidative stress generated by sodium arsenite. Food Chem Toxicol. 2009 Oct;47(10):2551-6. [3]. Beatty A, et, al. Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1. Nat Commun. 2021 Apr 14;12(1):2244.

Density	0.9±0.1 g/cm3
Boiling Point	390.6±11.0 °C at 760 mmHg
Molecular Formula	C₁₈H₃₀O₂
Molecular Weight	278.430
Flash Point	287.4±14.4 °C
Exact Mass	278.224579
PSA	37.30000
LogP	6.66
Vapour Pressure	0.0±1.9 mmHg at 25°C
Index of Refraction	1.491

Precursor 7
111699-15-1 112-77-6 110-53-2 111699-11-7
111699-14-0 111699-13-9 111699-12-8
DownStream 6
505-48-6 107-92-6 123-99-9 109-52-4
57-11-4 4175-47-7

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