Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: cis-4-Hydroxy-L-proline
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618-27-9

618-27-9 structure

Name: cis-4-hydroxy-L-proline
Chemical Name: cis-4-hydroxy-L-proline
CAS Number: 618-27-9
Molecular Formula: C₅H₉NO₃
Molecular Weight: 131.130
Catalog: Biochemical Amino acids and their derivatives Proline derivatives
Create Date: 2018-09-27 18:02:40
Modify Date: 2026-07-08 18:52:41
cis-4-Hydroxy-L-proline, a proline analogue, is an inhibitor of collagen production. cis-4-Hydroxy-L-proline could inhibit fibroblast growth by preventing the deposition of triple-helical collagen on the cell layer. cis-4-Hydroxy-L-proline also depresses the growth of primary N-nitrosomethylurea-induced rat mammary tumors[1][2][3][4].

Name	cis-4-hydroxy-L-proline
Synonyms	(2S,4S)-(-)-4-HYDROXY-2-PYRROLINECBOXYLIC ACID cis-4-Hydroxy-L-proline Vetec(TM) ade H-CIS-HYP-OH ALLO-HYDROXYPROLINE H-PRO(CIS-4-OH)-OH (2S,4S)-4-HYDROXY-L-PROLINE EINECS 210-542-1 proline,collagen,Inhibitor,cis4HydroxyLproline,tumor,cis 4 Hydroxy L proline,inhibit,Endogenous Metabolite,fibroblast (2S,4S)-4-hydroxypyrrolidine-2-cboxylic acid/cis-4-Hydroxy-L-proline Cis-4-Hydroxy-L-proline methyl ester (2S,4S)-(-)-4-Hydroxypyrrolidine-2-cboxylic acid cis-4-Hydroxy- L -proline (2S)-4α-Hydroxy-2α-pyrrolidinecboxylic acid MFCD00064319 cis L CIS-HYDROXYPROLINE L-ALLO-4-HYDROXY-2-PYRROLIDINECBOXYLLIC ACID cis-4-Hydroxy-L-proline //BP cis-4-Hydroxy-L-proline collagen synthesis inhibitor cis-4-L-Hydroxyproline CIS-4-HYDROXY-L-PROLINE NATURAL ISOMER (2S,4S)-4-hydroxypyrrolidine-2-cboxylic acid hydrochloride (2S,4S)-cis-4-hydroxy-L-proline cis-4-Hydroxy-L-proline Hydrochloride,e.e cis-L-Hyp-OH CIS-HYP-OH HYDROXY-L-PROLINE [ALLO] cis-4-Hydroxy-L-proline> (2S,4S)-4-Hydroxyproline (4S)-4-Hydroxy-L-prolin (2S,4S)-4-HYDROXYPYRROLIDINE-2-CBOXYLIC ACID L-Proline, 4-hydroxy-, (4S) (S)-Allo-hydroxyproline (2S,4S)-4-hydroxypyrrolidine-2-carboxylic acid cis-4-Hydroxy-L cis-4-Hydroxy-D-proline cis-L-4-Hydroxyproline (NMR) cis-Hydroxy-L-proline CIS-L-4-HYDROXYPROLINE CIS-4-HYDROXY-L-PROLINE HYDROLORIDE H-L-CIS-HYP-OH L-CIS-4-HYDROXYPROLINE (4S)-4-Hydroxy-L-proline (4S)-4-hydroxypyrrolidine-2-cboxylic acid CIS-4-HYDROXYPROLINE L-ALLO-HYDROXYPROLINE 4-CIS-HYDROXYPROLINE Coclaurine Impurity 4 L-ALLO-4-HYDROXY-2-PYRROLIDINECBOXYLIC ACID (4R)-4-Hydroxy-D-proline cis-4-Hydroxyproline CIS-4-HYDROXY-L-PROLINE (2S,4S)-(-)-4-Hydroxypyrrolidin-2-ylcboxylic acid Cis-4-hydroxy-L-proline Hyadrochloride ALLO-4-HYDROXY-L-PROLINE cis-4-Hydroxy-L-proline, (T) cis-4-Hydroxy-L-proline L-CIS-HYDROXYPROLINE, (2S,4S)-(-)-4-HYDROXY-2-PYRROLINECBOXYLIC ACID L-CIS-HYDROXYPROLINE

Description	cis-4-Hydroxy-L-proline, a proline analogue, is an inhibitor of collagen production. cis-4-Hydroxy-L-proline could inhibit fibroblast growth by preventing the deposition of triple-helical collagen on the cell layer. cis-4-Hydroxy-L-proline also depresses the growth of primary N-nitrosomethylurea-induced rat mammary tumors[1][2][3][4].
Related Catalog	Research Areas >> Cancer Research Areas >> Metabolic Disease
References	[1]. Lewko WM, et, al. Sensitivity of N-nitrosomethylurea-induced rat mammary tumors to cis-hydroxyproline, an inhibitor of collagen production. Cancer Res. 1981 Jul;41(7):2855-62. [2]. Kao WW, et, al. Proline analogue removes fibroblasts from cultured mixed cell populations. Nature. 1977 Mar 3;266(5597):63-4. [3]. Tan EM, et, al. Proline analogues inhibit human skin fibroblast growth and collagen production in culture. J Invest Dermatol. 1983 Apr;80(4):261-7. [4]. Riley DJ, et, al. Prevention of bleomycin-induced pulmonary fibrosis in the hamster by cis-4-hydroxy-l-proline. Am Rev Respir Dis. 1981 Apr;123(4 Pt 1):388-93.

Density	1.4±0.1 g/cm3
Boiling Point	355.2±42.0 °C at 760 mmHg
Melting Point	257ºC
Molecular Formula	C₅H₉NO₃
Molecular Weight	131.130
Flash Point	168.6±27.9 °C
Exact Mass	131.058243
PSA	69.56000
LogP	-1.84
Vapour Pressure	0.0±1.8 mmHg at 25°C
Index of Refraction	1.540

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2933990090

Precursor 10
13504-86-4 132592-07-5 147-85-3 51-35-4
13504-85-3 157401-62-2 177186-30-0 176966-58-8
13500-53-3 87691-27-8
DownStream 8
32563-24-9 189249-10-3 87691-27-8 2438-57-5
13504-86-4 3129-48-4 81102-38-7 942308-58-9

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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