cis-4-hydroxy-L-proline

Modify Date: 2024-01-02 23:48:26

cis-4-hydroxy-L-proline Structure
cis-4-hydroxy-L-proline structure
 Common Name cis-4-hydroxy-L-proline
CAS Number 618-27-9 Molecular Weight 131.130
Density 1.4±0.1 g/cm3 Boiling Point 355.2±42.0 °C at 760 mmHg
Molecular Formula C5H9NO3 Melting Point 257ºC
MSDS Chinese USA Flash Point 168.6±27.9 °C

 Use of cis-4-hydroxy-L-proline


cis-4-Hydroxy-L-proline, a proline analogue, is an inhibitor of collagen production. cis-4-Hydroxy-L-proline could inhibit fibroblast growth by preventing the deposition of triple-helical collagen on the cell layer. cis-4-Hydroxy-L-proline also depresses the growth of primary N-nitrosomethylurea-induced rat mammary tumors[1][2][3][4].

 Names

Name cis-4-hydroxy-L-proline
Synonym More Synonyms

 cis-4-hydroxy-L-proline Biological Activity

Description cis-4-Hydroxy-L-proline, a proline analogue, is an inhibitor of collagen production. cis-4-Hydroxy-L-proline could inhibit fibroblast growth by preventing the deposition of triple-helical collagen on the cell layer. cis-4-Hydroxy-L-proline also depresses the growth of primary N-nitrosomethylurea-induced rat mammary tumors[1][2][3][4].
Related Catalog
References

[1]. Lewko WM, et, al. Sensitivity of N-nitrosomethylurea-induced rat mammary tumors to cis-hydroxyproline, an inhibitor of collagen production. Cancer Res. 1981 Jul;41(7):2855-62.

[2]. Kao WW, et, al. Proline analogue removes fibroblasts from cultured mixed cell populations. Nature. 1977 Mar 3;266(5597):63-4.

[3]. Tan EM, et, al. Proline analogues inhibit human skin fibroblast growth and collagen production in culture. J Invest Dermatol. 1983 Apr;80(4):261-7.

[4]. Riley DJ, et, al. Prevention of bleomycin-induced pulmonary fibrosis in the hamster by cis-4-hydroxy-l-proline. Am Rev Respir Dis. 1981 Apr;123(4 Pt 1):388-93.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 355.2±42.0 °C at 760 mmHg
Melting Point 257ºC
Molecular Formula C5H9NO3
Molecular Weight 131.130
Flash Point 168.6±27.9 °C
Exact Mass 131.058243
PSA 69.56000
LogP -1.84
Vapour Pressure 0.0±1.8 mmHg at 25°C
Index of Refraction 1.540

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2933990090

 Synthetic Route

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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 Synonyms

D-Proline, 4-hydroxy-, (4R)-
(2S,4S)-4-hydroxypyrrolidine-2-carboxylic acid
cis-4-Hydroxy-L-proline
(4R)-4-Hydroxy-D-proline
cis-4-Hydroxyproline
MFCD00064319
(4S)-4-Hydroxy-L-prolin
cis-4-Hydroxy-D-proline
EINECS 210-542-1
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