117796-52-8

• 常用中文名：N-乙酰去氯雷他定
• 常用英文名：Sch 37370
• CAS号：117796-52-8
• 分子式：C₂₁H₂₁ClN₂O
• 分子量：352.85700
• 相关类别： 信号通路 G 蛋白偶联受体/G 蛋白 组胺受体
• 发布时间：2017-06-18 05:05:30
• 更新时间：2026-07-01 20:29:09
• N-Acetyldesloratadine (SCH-37370) 是一种有效的,具有口服活性的血小板激活因子 (PAF) 和组胺的双重拮抗剂。N-Acetyldesloratadine 可抑制 PAF 诱导的人血小板聚集,IC50 值为 0.6 µM。

名称

• 中文名: N-乙酰去氯雷他定
• 英文名: 1-[4-(8-chloro-5,6-dihydrobenzo[1,2]cyclohepta[2,4-b]pyridin-11-ylidene)piperidin-1-yl]ethanone
• 英文别名: RESPATADINE; 1-Acetyl-4-[(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohta[1,2-b]pyridin)-11-ylidene]piperidine; N-AcylImpurity; 1-[4-[(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohta[1,2-b]pyridine)-11-ylidene]piperidino]ethanone; 1-(4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohta[1,2-b]pyridin-11-ylidene)piperidin-1-yl)ethan-1-one; N-Acetyldesloratadine; N-Acetyldesloratadine (Desloratadine Impurity); Ethanone, 1-[4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohta[1,2-b]pyridin-11-ylidene)-1-piperidinyl]; Sch 37370 //BP; N-Acetyl Desloratadine; SCH37370,SCH; N-acetyl base loratadine; Desloratadine impurity III (Desloratadine n-acetyl impurity)"; SCH-37370, 10 mM in DMSO; PegCNTF; Sch; 1-(4-(8-chloro-5H-benzo[5,6]cyclohta[1,2-b]pyridin-11(6H)-ylidene)piperidin-1-yl)ethanone; 1-[4-(8-chloro-5,6-dihydrobenzo[1,2]cyclohta[2,4-b]pyridin-11-ylidene)piperidin-1-yl]ethanone; Desloratadine N-Acetyl Impurity Desloratadine N-Acetyl Impurity; Loratadine Impurity 11; N-Acetyldesloratadine N; Acetyldesloratadine

物化性质

• 密度: 1.257g/cm3
• 沸点: 546.9ºC at 760mmHg
• 分子式: C₂₁H₂₁ClN₂O
• 分子量: 352.85700
• 闪点: 284.5ºC
• 精确质量: 352.13400
• PSA: 33.20000
• LogP: 4.21570
• 蒸汽压: 5.15E-12mmHg at 25°C
• 折射率: 1.626
• 储存条件: -20°C

生物活性

• 描述: N-Acetyldesloratadine (SCH-37370) 是一种有效的,具有口服活性的血小板激活因子 (PAF) 和组胺的双重拮抗剂。N-Acetyldesloratadine 可抑制 PAF 诱导的人血小板聚集,IC50 值为 0.6 µM。
• 相关类别:
  信号通路 >> 免疫及炎症 >> 组胺受体
  研究领域 >> 炎症/免疫
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 组胺受体
• 参考文献:

  [1]. Billah MM, et, al. Discovery and preliminary pharmacology of Sch 37370, a dual antagonist of PAF and histamine. Lipids. 1991 Dec;26(12):1172-4.

合成路线

100643-71-8 75-36-5 ~% 117796-52-8

文献：Mu, Shuai; Xie, Xiao-Shuai; Niu, Duan; Zhang, Da-Shuai; Liu, Deng-Ke; Liu, Chang-Xiao Chinese Chemical Letters, 2013 , vol. 24, # 6 p. 531 - 534

108-24-7 100643-71-8 ~81% 117796-52-8

文献：Mezei, Tibor; Volk, Balazs; Kiraly, Imre; Simig, Gyula Organic Process Research and Development, 2008 , vol. 12, # 5 p. 855 - 859

32998-95-1 ~% 117796-52-8

文献：Piwinski, John J.; Wong, Jesse K.; Green, Michael J.; Ganguly, Ashit K.; Billah, M. Motasim; et al. Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 457 - 461

31255-57-9 ~% 117796-52-8

文献：Piwinski, John J.; Wong, Jesse K.; Green, Michael J.; Ganguly, Ashit K.; Billah, M. Motasim; et al. Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 457 - 461

107285-30-3 ~% 117796-52-8

文献：Piwinski, John J.; Wong, Jesse K.; Green, Michael J.; Ganguly, Ashit K.; Billah, M. Motasim; et al. Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 457 - 461

130642-50-1 ~% 117796-52-8

文献：Piwinski, John J.; Wong, Jesse K.; Green, Michael J.; Ganguly, Ashit K.; Billah, M. Motasim; et al. Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 457 - 461

79794-75-5 ~% 117796-52-8

文献：Piwinski, John J.; Wong, Jesse K.; Green, Michael J.; Ganguly, Ashit K.; Billah, M. Motasim; et al. Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 457 - 461

620-20-2 ~% 117796-52-8

文献：Piwinski, John J.; Wong, Jesse K.; Green, Michael J.; Ganguly, Ashit K.; Billah, M. Motasim; et al. Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 457 - 461

38092-89-6 ~% 117796-52-8

文献：Piwinski, John J.; Wong, Jesse K.; Green, Michael J.; Ganguly, Ashit K.; Billah, M. Motasim; et al. Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 457 - 461

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