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90952-27-5

90952-27-5 structure
90952-27-5 structure
  • Name: Thiol-PEG4-alcohol
  • Chemical Name: 2-[2-[2-(2-sulfanylethoxy)ethoxy]ethoxy]ethanol
  • CAS Number: 90952-27-5
  • Molecular Formula: C8H18O4S
  • Molecular Weight: 210.29100
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2017-08-20 18:29:52
  • Modify Date: 2024-01-09 16:06:47
  • Thiol-PEG4-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name 2-[2-[2-(2-sulfanylethoxy)ethoxy]ethoxy]ethanol
Synonyms 11-mercapto-3,6,9-trioxaundecanol
Ethanol,2-[2-[2-(2-mercaptoethoxy)ethoxy]ethoxy]
tetraethylene glycol monothiol
11-mercapto-3,6,9-trioxyundecan-1-ol
12-mercapto-3,6,9,12-tetraoxadodecan-1-ol
1-mercapto-11-hydroxy-3,6,9-trioxaundecane
mercaptotetraethylene glycol
Description Thiol-PEG4-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Molecular Formula C8H18O4S
Molecular Weight 210.29100
Exact Mass 210.09300
PSA 86.72000
Hazard Codes C