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198470-84-7

198470-84-7 structure
198470-84-7 structure
  • Name: parecoxib
  • Chemical Name: parecoxib
  • CAS Number: 198470-84-7
  • Molecular Formula: C19H18N2O4S
  • Molecular Weight: 370.422
  • Catalog: API Antipyretic analgesics Analgesic
  • Create Date: 2018-05-07 08:00:00
  • Modify Date: 2025-08-20 12:15:45
  • Parecoxib is a potent and selective COX-2 inhibitor.IC50 value:Target: COX-2in vitro: The prodrug Parecoxib as well as its active metabolite val have a specific affinity to the cannabinoid (CB) receptor measured in CB1-expressing HEK 293 cells and rat brain tissue [1].in vivo: Adult male Sprague-Dawley rats were administered parecoxib (10 or 30 mg kg(-1), IP) or isotonic saline twice a day starting 24 h after middle cerebral artery occlusion (MCAO) for three consecutive days [2]. The selective COX-2 inhibitor parecoxib was delivered 20 min before or 20 min after the incision by intraperitoneal injection. Pretreatment with parecoxib markedly attenuated the pain hypersensitivity induced by incision [3].
Name parecoxib
Synonyms N-{[4-(5-Methyl-3-phenyl-1,2-oxazol-4-yl)phenyl]sulfonyl}propanamide
N-[[4-[5-methyl-3-phenylisoxazol-4-yl]phenyl]sulfonyl]propanamide
parecoxib
N-[[4-(5-methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]-propanamide
4-[4-(N-propionylsulfamoyl)-phenyl]-5-methyl-3-phenyl-isoxazole
N-propanoyl-4-(5-methyl-3-phenylisoxazol-4-yl)benzenesulfonamide
Propanamide, N-[[4-(5-methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]-
N-[[4-[5-methyl-3-phenylisoxazol-4-yl]phenyl]sulfonyl]acetamide
Dynastat
Description Parecoxib is a potent and selective COX-2 inhibitor.IC50 value:Target: COX-2in vitro: The prodrug Parecoxib as well as its active metabolite val have a specific affinity to the cannabinoid (CB) receptor measured in CB1-expressing HEK 293 cells and rat brain tissue [1].in vivo: Adult male Sprague-Dawley rats were administered parecoxib (10 or 30 mg kg(-1), IP) or isotonic saline twice a day starting 24 h after middle cerebral artery occlusion (MCAO) for three consecutive days [2]. The selective COX-2 inhibitor parecoxib was delivered 20 min before or 20 min after the incision by intraperitoneal injection. Pretreatment with parecoxib markedly attenuated the pain hypersensitivity induced by incision [3].
Related Catalog
Target

COX-2

References

[1]. Ye Z, et al. Delayed administration of parecoxib, a specific COX-2 inhibitor, attenuated postischemic neuronal apoptosis by phosphorylation Akt and GSK-3β. Neurochem Res. 2012 Feb;37(2):321-9.

[2]. Schr?der H, et al. Parecoxib and its metabolite valdecoxib directly interact with cannabinoid binding sites in CB1-expressing HEK 293 cells and rat brain tissue. Neurochem Int. 2011 Jan;58(1):9-13.

[3]. Guo YJ, et al. Analgesic effects of the COX-2 inhibitor parecoxib on surgical pain through suppression of spinal ERK signaling. Exp Ther Med. 2013 Jul;6(1):275-279.
Density 1.3±0.1 g/cm3
Melting Point 148.9-151°
Molecular Formula C19H18N2O4S
Molecular Weight 370.422
Exact Mass 370.098724
PSA 101.14000
LogP 1.72
Index of Refraction 1.580
Symbol GHS08
GHS08
Signal Word Warning
Hazard Statements H361d-H373
Precautionary Statements P281
Hazard Codes Xn,N
Risk Phrases 63-48/22-51/53
Safety Phrases 36/37-61
RIDADR NONH for all modes of transport
RTECS TX1478700
123-62-6 structure

123-62-6

181695-72-7 structure

181695-72-7

~82%

198470-84-7 structure

198470-84-7

Literature: Talley, John J.; Bertenshaw, Stephen R.; Brown, David L.; Carter, Jeffery S.; Graneto, Matthew J.; Kellogg, Michael S.; Koboldt, Carol M.; Yuan, Jinhua; Zhang, Yan Y.; Seibert, Karen Journal of Medicinal Chemistry, 2000 , vol. 43, # 9 p. 1661 - 1663
181695-72-7 structure

181695-72-7

~75%

198470-84-7 structure

198470-84-7

Literature: Letendre, Leo J.; Kunda, Sastry A.; Gallagher, Donald J.; Seaney, Lisa M.; McLaughlin, Kathleen Patent: US2003/105334 A1, 2003 ;
Precursor  2

DownStream  0

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