198470-84-7

198470-84-7 structure

Name: parecoxib
Chemical Name: parecoxib
CAS Number: 198470-84-7
Molecular Formula: C₁₉H₁₈N₂O₄S
Molecular Weight: 370.422
Catalog: API Antipyretic analgesics Analgesic
Create Date: 2018-05-07 08:00:00
Modify Date: 2024-01-02 16:15:41
Parecoxib is a potent and selective COX-2 inhibitor.IC50 value:Target: COX-2in vitro: The prodrug Parecoxib as well as its active metabolite val have a specific affinity to the cannabinoid (CB) receptor measured in CB1-expressing HEK 293 cells and rat brain tissue [1].in vivo: Adult male Sprague-Dawley rats were administered parecoxib (10 or 30 mg kg(-1), IP) or isotonic saline twice a day starting 24 h after middle cerebral artery occlusion (MCAO) for three consecutive days [2]. The selective COX-2 inhibitor parecoxib was delivered 20 min before or 20 min after the incision by intraperitoneal injection. Pretreatment with parecoxib markedly attenuated the pain hypersensitivity induced by incision [3].

Name	parecoxib
Synonyms	N-{[4-(5-Methyl-3-phenyl-1,2-oxazol-4-yl)phenyl]sulfonyl}propanamide N-[[4-[5-methyl-3-phenylisoxazol-4-yl]phenyl]sulfonyl]propanamide parecoxib N-[[4-(5-methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]-propanamide 4-[4-(N-propionylsulfamoyl)-phenyl]-5-methyl-3-phenyl-isoxazole N-propanoyl-4-(5-methyl-3-phenylisoxazol-4-yl)benzenesulfonamide Propanamide, N-[[4-(5-methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]- N-[[4-[5-methyl-3-phenylisoxazol-4-yl]phenyl]sulfonyl]acetamide Dynastat

Description	Parecoxib is a potent and selective COX-2 inhibitor.IC50 value:Target: COX-2in vitro: The prodrug Parecoxib as well as its active metabolite val have a specific affinity to the cannabinoid (CB) receptor measured in CB1-expressing HEK 293 cells and rat brain tissue [1].in vivo: Adult male Sprague-Dawley rats were administered parecoxib (10 or 30 mg kg(-1), IP) or isotonic saline twice a day starting 24 h after middle cerebral artery occlusion (MCAO) for three consecutive days [2]. The selective COX-2 inhibitor parecoxib was delivered 20 min before or 20 min after the incision by intraperitoneal injection. Pretreatment with parecoxib markedly attenuated the pain hypersensitivity induced by incision [3].
Related Catalog	Research Areas >> Inflammation/Immunology
Target	COX-2
References	[1]. Ye Z, et al. Delayed administration of parecoxib, a specific COX-2 inhibitor, attenuated postischemic neuronal apoptosis by phosphorylation Akt and GSK-3β. Neurochem Res. 2012 Feb;37(2):321-9. [2]. Schr?der H, et al. Parecoxib and its metabolite valdecoxib directly interact with cannabinoid binding sites in CB1-expressing HEK 293 cells and rat brain tissue. Neurochem Int. 2011 Jan;58(1):9-13. [3]. Guo YJ, et al. Analgesic effects of the COX-2 inhibitor parecoxib on surgical pain through suppression of spinal ERK signaling. Exp Ther Med. 2013 Jul;6(1):275-279.

Density	1.3±0.1 g/cm3
Melting Point	148.9-151°
Molecular Formula	C₁₉H₁₈N₂O₄S
Molecular Weight	370.422
Exact Mass	370.098724
PSA	101.14000
LogP	1.72
Index of Refraction	1.580

Symbol	GHS08
Signal Word	Warning
Hazard Statements	H361d-H373
Precautionary Statements	P281
Hazard Codes	Xn,N
Risk Phrases	63-48/22-51/53
Safety Phrases	36/37-61
RIDADR	NONH for all modes of transport
RTECS	TX1478700

123-62-6

181695-72-7

~82%

198470-84-7

Literature: Talley, John J.; Bertenshaw, Stephen R.; Brown, David L.; Carter, Jeffery S.; Graneto, Matthew J.; Kellogg, Michael S.; Koboldt, Carol M.; Yuan, Jinhua; Zhang, Yan Y.; Seibert, Karen Journal of Medicinal Chemistry, 2000 , vol. 43, # 9 p. 1661 - 1663

181695-72-7

~75%

198470-84-7

Literature: Letendre, Leo J.; Kunda, Sastry A.; Gallagher, Donald J.; Seaney, Lisa M.; McLaughlin, Kathleen Patent: US2003/105334 A1, 2003 ;

Precursor 2
123-62-6 181695-72-7
DownStream 0

198470-84-7	1709956-95-5
197502-82-2	198470-85-8
1708094-99-8	198471-83-9
198471-06-6	386273-25-2
1373038-59-5	952-06-7