77074-49-8
77074-49-8 structure
- Name: Thyroxine sulfate
- Chemical Name: thyroxine sulfate
- CAS Number: 77074-49-8
- Molecular Formula: C15H11I4NO7S
- Molecular Weight: 856.93300
- Catalog: Research Areas Metabolic Disease
- Create Date: 2017-09-09 09:24:31
- Modify Date: 2024-01-11 11:51:39
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Thyroxine sulfate is a thyroid hormone metabolite.
| Name | thyroxine sulfate |
|---|---|
| Synonyms |
Thyroxine Hydrogen Sulfate
Thyroxine sulfate (2S)-2-amino-3-[4-(3,5-diiodo-4-sulfooxyphenoxy)-3,5-diiodophenyl]propanoic acid Thyroxine 4'-O-Sulfate |
| Description | Thyroxine sulfate is a thyroid hormone metabolite. |
|---|---|
| Related Catalog | |
| Target |
Human Endogenous Metabolite |
| In Vitro | Thyroxine sulfate (T4S) is a normal component of human serum and amniotic fluid, and it is mostly derived from thyroxine peripherally and accumulates when type I 5-monodeiodinating activity is low in fetuses or inhibited by drugs, such as ipodate[1]. |
| In Vivo | Significant amounts of thyroxine sulfate (T4S) in fetal sheep serum, meconium, bile, and amniotic and allantoic fluids are observed. T4S concentration in amniotic fluid from women at 18-19 weeks of gestation (25.5 ng/dL) is higher than that at 14-15 weeks of gestation (14.3 ng/dL). A significant rise in serum T4S is detected in hyperthyroid patients 1 day after ingestion of 1 g of ipodate[1]. Thyroxine undergoes significant sulfation in rats, and biliary excretion of T4S is enhanced if its type I deiodination is inhibited[2]. Serum T4S levels are clearly elevated compared with healthy references, and the decreased deiodination by liver D1 during critical illness appears to play a role in this increase in serum T4S levels[3]. |
| References |
| Molecular Formula | C15H11I4NO7S |
|---|---|
| Molecular Weight | 856.93300 |
| Exact Mass | 856.64400 |
| PSA | 144.53000 |
| LogP | 5.81440 |