Thyroxine sulfate

Modify Date: 2024-01-11 11:51:39

Thyroxine sulfate structure	Common Name	Thyroxine sulfate
	CAS Number	77074-49-8	Molecular Weight	856.93300
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₅H₁₁I₄NO₇S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Thyroxine sulfate

Thyroxine sulfate is a thyroid hormone metabolite.

Name	thyroxine sulfate
Synonym	More Synonyms

Description	Thyroxine sulfate is a thyroid hormone metabolite.
Related Catalog	Signaling Pathways >> Others >> Thyroid Hormone Receptor Natural Products >> Acids and Aldehydes Research Areas >> Metabolic Disease
Target	Human Endogenous Metabolite
In Vitro	Thyroxine sulfate (T4S) is a normal component of human serum and amniotic fluid, and it is mostly derived from thyroxine peripherally and accumulates when type I 5-monodeiodinating activity is low in fetuses or inhibited by drugs, such as ipodate[1].
In Vivo	Significant amounts of thyroxine sulfate (T4S) in fetal sheep serum, meconium, bile, and amniotic and allantoic fluids are observed. T4S concentration in amniotic fluid from women at 18-19 weeks of gestation (25.5 ng/dL) is higher than that at 14-15 weeks of gestation (14.3 ng/dL). A significant rise in serum T4S is detected in hyperthyroid patients 1 day after ingestion of 1 g of ipodate[1]. Thyroxine undergoes significant sulfation in rats, and biliary excretion of T4S is enhanced if its type I deiodination is inhibited[2]. Serum T4S levels are clearly elevated compared with healthy references, and the decreased deiodination by liver D1 during critical illness appears to play a role in this increase in serum T4S levels[3].
References	[1]. Wu SY, et al. Identification of thyroxine-sulfate (T4S) in human serum and amniotic fluid by a novel T4S radioimmunoassay. Thyroid. 1992 Summer;2(2):101-5. [2]. Rutgers M, et al. Effects of propylthiouracil on the biliary clearance of thyroxine (T4) in rats: decreased excretion of 3,5,3'-triiodothyronine glucuronide and increased excretion of 3,3',5'-triiodothyronine glucuronide and T4 sulfate. Endocrinology. 1989 Oct;125(4):2175-86. [3]. Peeters RP, et al. Increased thyroxine sulfate levels in critically ill patients as a result of a decreased hepatic type Ideiodinase activity. J Clin Endocrinol Metab. 2005 Dec;90(12):6460-5.

Molecular Formula	C₁₅H₁₁I₄NO₇S
Molecular Weight	856.93300
Exact Mass	856.64400
PSA	144.53000
LogP	5.81440

Thyroxine Hydrogen Sulfate

Thyroxine sulfate

(2S)-2-amino-3-[4-(3,5-diiodo-4-sulfooxyphenoxy)-3,5-diiodophenyl]propanoic acid

Thyroxine 4'-O-Sulfate

DC Chemicals Limited
China
Product Name: Thyroxine sulfate
Price: $Inquiry/100mg $96.0/10mg $256.0/50mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: O-[3,5-diiodo-4-(sulfooxy)phenyl]-3,5-diiodo L-tyrosine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Price: $136/10mM*1mLinDMSO

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Thyroxine sulfate

Use of Thyroxine sulfate

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Thyroxine sulfate Biological Activity

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