Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Ethyl [(4-methylphenyl)sulfonyl]carbamate
Price: ￥408.0/250mg ￥978.0/1g
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Ethyl tosylcarbamate
Price:
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Ethyl N-(4-methylphenyl)sulfonylcarbamate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

5577-13-9

5577-13-9 structure

Name: Ethyl [(4-methylphenyl)sulfonyl]carbamate
Chemical Name: Ethyl N-(4-methylphenyl)sulfonylcarbamate
CAS Number: 5577-13-9
Molecular Formula: C₁₀H₁₃NO₄S
Molecular Weight: 243.279
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Potassium Channel
Create Date: 2018-12-18 13:44:21
Modify Date: 2024-01-02 12:06:37
Ethyl tosylcarbamate is an intermediate in the synthesis of Gliclazide (G409877)[1][2]. Gliclazide is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM[3].

Name	Ethyl N-(4-methylphenyl)sulfonylcarbamate
Synonyms	Tosylcarbamic acid ethyl ester Ethyl [(4-methylphenyl)sulfonyl]carbamate ethyl N-(4-toluenesulfonyl)carbamate ethyl tosylcarbaMate Ethyl [(4-methylphenyl)sulphonyl]carbamate Carbamic acid, N-[(4-methylphenyl)sulfonyl]-, ethyl ester Tosylurethane ethoxycarbonamide of p-toluenebenzenesulfoacid ethyl p-tosylcarbamate (toluene-4-sulfonyl)-carbamic acid ethyl ester ethyl N-(tosyl)carbamate Carbamic acid, [(4-methylphenyl)sulfonyl]-, ethyl ester N-(4-methylphenyl)sulfonylcarbamic acid ethyl ester 2OVMSWR D1 N-(p-Tolylsulfonyl)carbamic acid ethyl ester

Description	Ethyl tosylcarbamate is an intermediate in the synthesis of Gliclazide (G409877)[1][2]. Gliclazide is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM[3].
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
References	[1]. Holmes B, et al. Gliclazide. A preliminary review of its pharmacodynamic properties and therapeutic efficacy in diabetes mellitus. Drugs. 1984 Apr;27(4):301-27. [2]. Rebecka Isaksson, et al. Rapid and straightforward transesterification of sulfonyl carbamates. Tetrahedron Letters, 57(13), 1476–1478. [3]. Shimoyama, T., et al., Gliclazide protects 3T3L1 adipocytes against insulin resistance induced by hydrogen peroxide with restoration of GLUT4 translocation. Metabolism, 2006. 55(6): p. 722-30.

Density	1.3±0.1 g/cm3
Molecular Formula	C₁₀H₁₃NO₄S
Molecular Weight	243.279
Exact Mass	243.056534
PSA	80.85000
LogP	1.86
Index of Refraction	1.530

Hazard Codes	Xi
HS Code	2935009090

541-41-3

70-55-3

~88%

5577-13-9

Literature: Xi, Pin-xian; Xu, Zhi-hong; Liu, Xiao-hui; Cheng, Feng-juan; Zeng, Zheng-zhi Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2008 , vol. 71, # 2 p. 523 - 528 Title/Abstract Full Text View citing articles Show Details Xi, Pin-Xian; Xu, Zhi-Hong; Liu, Xiao-Hui; Chen, Feng-Juan; Huang, Liang; Zeng, Zheng-Zhi Chemical and Pharmaceutical Bulletin, 2008 , vol. 56, # 4 p. 541 - 546

4083-64-1

5577-13-9

Literature: US5326796 A1, ;

5219-81-8

105-58-8

~91%

5577-13-9

Literature: Guo, Xiaoguang; Shang, Jianpeng; Li, Jian; Wang, Liguo; Ma, Yubo; Shi, Feng; Deng, Youquan Synthetic Communications, 2011 , vol. 41, # 8 p. 1102 - 1111

70-55-3

1608-26-0

~33%

5577-13-9

Literature: Bittner, Shmuel; Assaf, Yonit; Krief, Penina; Pomerantz, Martin; Ziemnicka, Barbara T.; Smith, Christina G. Journal of Organic Chemistry, 1985 , vol. 50, # 10 p. 1712 - 1718

10439-23-3

5577-13-9

Literature: J. Gen. Chem. USSR (Engl. Transl.), , vol. 31, p. 2381 - 2385,2218 - 2222

93506-31-1

5577-13-9

Literature: J. Gen. Chem. USSR (Engl. Transl.), , vol. 31, p. 2381 - 2385,2218 - 2222

Precursor 7
541-41-3 70-55-3 4083-64-1 5219-81-8
105-58-8 1608-26-0 10439-23-3
DownStream 7
4083-64-1 28490-28-0 28490-61-1 28490-23-5
70-55-3 32234-75-6 664-95-9

HS Code	2935009090
Summary	2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

5577-13-9	826994-57-4
70176-69-1	70539-63-8
18303-04-3	56014-50-7
2850-19-3	18303-08-7
5255-66-3	1159976-53-0