287194-40-5
287194-40-5 structure
- Name: (-)-DHMEQ
- Chemical Name: 2-hydroxy-N-[(1S,2S,6S)-2-hydroxy-5-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]benzamide
- CAS Number: 287194-40-5
- Molecular Formula: C13H11NO5
- Molecular Weight: 261.23000
- Catalog: Signaling Pathways NF-κB NF-κB
- Create Date: 2016-12-22 05:01:38
- Modify Date: 2025-08-26 15:18:57
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(–)-DHMEQ is a potent NF-κB inhibitor.
| Name | 2-hydroxy-N-[(1S,2S,6S)-2-hydroxy-5-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]benzamide |
|---|---|
| Synonyms |
(-)-DHM2EQ
DHMEQ Dehydroxymethylepoxyquinomicin 2-Hydroxy-N-((1S,2S,6S)-2-hydroxy-5-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl)benzamide (-)-DHMEQ |
| Description | (–)-DHMEQ is a potent NF-κB inhibitor. |
|---|---|
| Related Catalog | |
| Target |
RelA RelB |
| In Vitro | (–)-DHMEQ binds to cysteine 38 of RelA and cysteine 144 of RelB. (−)-DHMEQ at concentrations greater than 25 µM inhibits the LTβ-induced nuclear translocation of FLAG-RelB WT, whereas the inhibitory effect of (–)-DHMEQ on the nuclear translocation of FLAG-RelB (C144S) became weaker at the same concentrations[1]. |
| Cell Assay | A549 cells transfectants stably expressing RelB WT and RelB (C144S) are preincubated with various concentrations of (-)-DHMEQ (1, 5, 10, 25, and 50 μM) for 1h and then incubated with or without LTβ (25 ng/mL) for 2 h in the presence or absence of (-)-DHMEQ.Cytoplasmic and nuclear extracts are analyzed by Western blotting[1]. |
| References |
| Molecular Formula | C13H11NO5 |
|---|---|
| Molecular Weight | 261.23000 |
| Exact Mass | 261.06400 |
| PSA | 102.65000 |
| LogP | 0.29170 |