Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Palmitic acid
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: lovastatin
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson
Email: info@tianfuchem.com

75330-75-5

75330-75-5 structure

75330-75-5 structure

Name: Lovastatin
Chemical Name: lovastatin
CAS Number: 75330-75-5
Molecular Formula: C₂₄H₃₆O₅
Molecular Weight: 404.540
Catalog: API Circulatory system medication Regulating blood lipids
Create Date: 2018-03-14 08:00:00
Modify Date: 2026-06-30 18:31:25
Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol.

Name	lovastatin
Synonyms	LOVASTATIN (CRM STANDD) Mevinolin, Monacolin K, L 154803, MB 530B, MSD LOVASTATIN Simvastatin Impurity 5(Simvastatin Impurity E) Mevinolin, 6-alpha-Methylcompactin 6-A-METHYLCOMPACTIN (2S)-2-methyl-butanoic acid (1S,3R,7S,8S,8-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester MEVINOLIN RedYeastRice (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate 2b,6a-Dimethyl-8a-(2-methyl-1-oxobutoxy)mevinic Acid Lactone 8-[2-(4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydro-1-nap 4-hydroxy-6-oxo-2h-pyran-2-yl)ethyl)-1-naphthalenylester,(1s-(1-alpha-(r),3 Lovastatin Solution, 1000ppm (2S)-2-Methylbutanoic acid (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester 8-[2-(4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethy l]-3,7-dimethyl-1,2,3,7,8,8a-hexahydro-1-naphthal 3r,7s,8s,8-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[2r,4r)-tetrahydro-(1 Lovastatin an inhibitor of HMG-CoA reductase LOVASTATION MK-803 Altocor 5-(4-broMophenyl)-1,2-thiazole MEVACOR (S)-2-METHYL-BUTYRIC ACID (1S,3R,7S,8S,8-8-[2-((2R,4R)-4-HYDROXY-6-OXO-TETRAHYDRO-PYRAN-2-YL)-ETHYL]-3,7-DIMETHYL-1,2,3,7,8,8A-HEXAHYDRO-NAPHTHALEN-1-YL ESTER MONACOLIN K 2-methyl-,1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahydro-butanoicaci Antibiotic MB 530B Lovastatin-d9 (Mixture of stereoisoMers) Altoprev (2S)-(1S,3R,7S,8S,8-1,2,3,7,8,8A-HEXAHYDRO-3,7-DIMETHYL-8-[2-[(2R,4R)-TETRAHYDRO-4-HYDROXY-6-OXO-2H-PYRAN-2-YL]ETHYL]-1-NAPHTHALENYL-2-METHYL BUTANOATE 4-hydroxy-6-oxo-2h-pyran-2-yl]ethyl]-1-naphthalenyl(s)-2-methyl-butyrate 6ALPHA-METHYLCOMPACTIN Sivlor 2BETA,6ALPHA-DIMETHYL-8ALPHA-(2-METHYL-1-OXOBUTOXY)MEVINIC ACID LACTONE (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl (S)-2-Methylbutyrate 8-[2-(4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydro-1-naphth MFCD00072164 3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2h-pyran-2-yl Lovastatin API Lovastatin (Mevacor) [8-[2-(4-hydroxy-6-oxooxan-2-yl)ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2-methylbutanoate 2-methylbutanoic acid [8-[2-(4-hydroxy-6-oxo-2-tetrahydropyranyl)ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl LOVALIP 5-KG TIN [8-[2-(4-hydroxy-6-oxo-tetrahydropyran-2-yl)ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2-methylbutanoate Lovastatin,Monacolin K LOVASTATIN MM(CRM STANDD) (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl-(2S)-2-methylbutanoat 1,2,6,7,8,8a-Hexahydro-b,d-dihydroxy-2,6-dimethyl-8-(2-methyl-1-oxobutoxy)-1-naphthaleneheptanoic Acid d-Lactone (+)-Mevinolin lMevinolin 6alpha-Methylcompactin Mevinolin Monacolin K )ethyl]-1-naphthalenylester LOVASTIN (2S)-(1S,3R,7S,8S)-8-(2-((2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2-methylbutanoate 8-[2-(4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2-methylbutanoate SiMvastatin IMpurity E Lovastatin 24 Lovastatin 23 Simvastatin Impurity 5 Mevinolin 6alpha-Methylcompactin Monacolin K oxy)-1-naphthalenehtanoicaciddelta-lactone Rovacor 6a-Methylcompactin MEVINACOR (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydro-1-naphthalenyl (2S)-2-methylbutanoate mevlor (1S,3R,7S,8S,8-8-{2-[(2R,4R)-4-Hydroxy-6-oxooxan-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate 1,2,6,7,8,8a-hexahydro-beta,delta-dihydroxy-2,6-dimethyl-8-(2-methyl-1-oxobuty 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2h-pyran-2-yl)ethyl]-1-naphthalenyl 2-methylbutanoate Lovastatin for peak identification [1s-[1alpha(r),3alpha,7beta,8beta(2s,4s),8abeta]]-2-methylbutanoicacid1,2 [1S-[1a(R),3a,7b,8b(2S,4S*),8ab]]-2-Methylbutanoic Acid1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl Ester msd803 Paschol

Description	Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> HMG-CoA Reductase (HMGCR) Research Areas >> Cardiovascular Disease
Target	HMG-CoA reductase[1]
In Vitro	Lovastatin is an inactive lactone prodrug that must be chemically or enzymatically converted to its dihydroxy open-acid form in order to elicit inhibitory activity. Lovastatin in its hydroxy acid form is an exceptionally potent competitive inhibitor of liver HMG CoA reductase[1]. Lovastatin, other than its anticholesterol property, has diverse applications in the field of osteoporosis, neuro-degeneration, rheumatoid arthritis, antifungals and also is reported to reduce proliferation of lung cancer cells, breast cancer (MCF-7), liver cancer (HepG2). Lovastatin treatments show significant dose dependent cytotoxic effect on HeLa cells with IC50 value of 160 μg/mL. Lovastatin is effective to accelerate hydroxyl radical scavenging activity (54.06%) at an IC50 of 3601 μg/mL[2].
In Vivo	Lovastatin is an inactive lactone that is hydrolyzed in the liver to an active f3-hydroxyacid form. This principal metabolite is the inhibitor of the enzyme HMG-CoA reductase. The Ki is 1 nM. Lovastatin and its β-hydroxyacid metabolite are highly bound to human plasma proteins. Lovastatin crosses the blood-brain and placental barriers[3]. Lovastatin produces a profound reduction of apolipoprotein-B-containing lipoproteins, especially LDL cholesterol and, to a lesser extent, plasma triglycerides, and a small increase in HDL cholesterol[4].
Cell Assay	Hela cells are treated with lovastatin (0, 5, 10, 20, 40, 80, 160, 320 μg/mL) for 24 h. Cells treated with culture medium serves as a negative control. cell viability is measured using the MTT based colorimetric assay [2].
References	[1]. Alberts AW, et al. Discovery, biochemistry and biology of lovastatin. Am J Cardiol. 1988 Nov 11;62(15):10J-15J. [2]. Bhargavi S, et al. Purification of Lovastatin from Aspergillus terreus (KM017963) and Evaluation of its Anticancer and Antioxidant Properties. Asian Pac J Cancer Prev. 2016;17(8):3797-803. [3]. Frishman WH, et al. Lovastatin: an HMG-CoA reductase inhibitor for lowering cholesterol. Med Clin North Am. 1989 Mar;73(2):437-48. [4]. Tobert JA, et al. Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors. Nat Rev Drug Discov. 2003 Jul;2(7):517-26.

Density	1.1±0.1 g/cm3
Boiling Point	559.2±50.0 °C at 760 mmHg
Melting Point	175°C
Molecular Formula	C₂₄H₃₆O₅
Molecular Weight	404.540
Flash Point	185.3±23.6 °C
Exact Mass	404.256287
PSA	72.83000
LogP	4.07
Vapour Pressure	0.0±3.4 mmHg at 25°C
Index of Refraction	1.532
Storage condition	2-8°C
Water Solubility	0.0004 mg/mL at 25 ºC

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Precautionary Statements	P301 + P312 + P330
Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S22-S24/25
RIDADR	3077
WGK Germany	3
RTECS	EK7907000
Packaging Group	III
Hazard Class	9
HS Code	2932999099

Precursor 2
79691-11-5 75225-51-3
DownStream 9
79902-31-1 79902-63-9 75225-50-2 67-64-1
75-65-0 109273-98-5 75225-51-3 151006-15-4
132748-10-8

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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