63585-09-1

63585-09-1 structure

Name: Foscarnet sodium
Chemical Name: trisodium phosphonoformate
CAS Number: 63585-09-1
Molecular Formula: CNa₃O₅P
Molecular Weight: 191.951
Catalog: API Synthetic anti-infective drugs Antiviral drugs
Create Date: 2018-09-25 10:31:13
Modify Date: 2026-07-04 10:41:32
Foscarnet sodium (Trisodium phosphonoformate) is a viral DNA polymerase activity inhibitor, leading to reversible suppression of viral replication. Foscarnet sodium is an antiherpesvirus agent used in cytomegalovirus retinitis[1][2][3].

Name	trisodium phosphonoformate
Synonyms	Phosphoranecarboxylic acid, 1,1-dihydroxy-, oxide, sodium salt (1:3) Triapten risodiumphosphonoformate MFCD00013973 FOSCNET SODIUM dihydroxyphosphinecboxylicacidoxidetrisodiumsalt Sodiooxycbonylphosphonic acid disodium salt SODIUM FOSCNET phosphonoformic acid trisodium salt Phenytion Sodium Foscavir trisodium phosphonato cbonate FOSCARNET TRISODIUM SALT (Sodiooxycbonyl)phosphonic acid disodium salt Foscnet (sodium salt) Foscnet & Foscnet Sodium trisodium dioxidophosphinecboxylate oxide Trisodium dioxidophosphinecarboxylate oxide trisodium cboxyphosphate Foscanet sodium foscnet sodim phosphoranecarboxylic acid, dihydroxy-, oxide, trisodium salt Foscnet sodium Trisodium phosphonoformate foscarnet sodim trisodium dioxidophosphanecarboxylate oxide SODIUM FOSCARNET a29622 FOSCNET Foscnet sodium //BP Sodiumphosphonatoformate phosphinecboxylicacid,dihydroxy-,oxide,trisodiumsalt FOSCNET TRISODIUM SALT Phosphinecboxylic acid, 1,1-dihydroxy-, 1-oxide, sodium salt (1:3) phosphonoformate sodium salt

Description	Foscarnet sodium (Trisodium phosphonoformate) is a viral DNA polymerase activity inhibitor, leading to reversible suppression of viral replication. Foscarnet sodium is an antiherpesvirus agent used in cytomegalovirus retinitis[1][2][3].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis
In Vitro	Foscarnet sodium (Trisodium phosphonoformate) inhibits Influenza A Victoria (IC50=29 μM), Influenza B HK (IC50=61 μM), and Avian myeloblastosis virus (IC50=5-8 μM),HSV-1, several strains (IC50=0.4-3.5 μM)[2].
References	[1]. Manischewitz JF, et al. Synergistic effect of ganciclovir and foscarnet on cytomegalovirus replication in vitro.Antimicrob Agents Chemother. 1990 Feb;34(2):373-5. [2]. Oberg B, et al. Antiviral effects of phosphonoformate (PFA, foscarnet sodium).Pharmacol Ther. 1982;19(3):387-415. [3]. Hakki M, et al. Moving Past Ganciclovir and Foscarnet: Advances in CMV Therapy.Curr Hematol Malig Rep. 2020 Jan 24.

CHEMICAL NAME :: Phosphinecarboxylic acid, dihydroxy-, oxide, trisodium salt

TOXIC EFFECTS :: Gastrointestinal - nausea or vomiting Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

REFERENCE :: LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 2,216,1987

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4215113

Hazard Codes	Xi
Risk Phrases	R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Phrases	S26-S36
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
Packaging Group	II
HS Code	2942000000

72304-84-8

~0%

63585-09-1

74270-25-0

Literature: Noren; Helgstrand; Johansson; Misiorny; Stening Journal of Medicinal Chemistry, 1983 , vol. 26, # 2 p. 264 - 270

91076-68-5

999-97-3

63585-09-1

Literature: Phosphorus, Sulfur and Silicon and the Related Elements, , vol. 51/52, p. 778

HS Code	2942000000