Synthesis of esters of phosphonoformic acid and their antiherpes activity

…, E Helgstrand, NG Johansson, A Misiorny…

Index: Noren; Helgstrand; Johansson; Misiorny; Stening Journal of Medicinal Chemistry, 1983 , vol. 26, # 2 p. 264 - 270

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Citation Number: 64

Abstract

Aliphatic and aromatic mono-, di-, and triesters of phosphonoformic acid (foscarnet) were synthesized. The triesters were prepared by the Michaelis-Arbuzov reaction and were hydrolyzed to di-and monoesters. The compounds were tested for antiviral activity on isolated herpes simplex virus type 1 (HSV-I) DNA polymerase, in a HSV-1 plaque reduction assay, and on a cutaneous HSV-1 infection in guinea pigs. None of the esters inhibited ...

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