5451-09-2
5451-09-2 structure
- Name: 5-Aminolevulinic acid hydrochloride
- Chemical Name: 5-Aminolevulinic Acid Hydrochloride
- CAS Number: 5451-09-2
- Molecular Formula: C5H10ClNO3
- Molecular Weight: 167.59
- Catalog: Biochemical Amino acids and their derivatives Amino acid salt
- Create Date: 2018-08-12 12:15:33
- Modify Date: 2026-06-30 22:42:54
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5-Aminolevulinic acid HCl is an intermediate in heme biosynthesis in the body and the universal precursor of tetrapyrroles.Target: Others5-Aminolevulinic acid is a non-fluorescent prodrug that leads to intracellular accumulation of fluorescent porphyrins in malignant gliomas-a finding that is under investigation for intraoperative identification and resection of these tumours. Median follow-up was 35.4 months (95% CI 1.0-56.7). Contrast-enhancing tumour was resected completely in 90 (65%) of 139 patients assigned 5-aminolevulinic acid compared with 47 (36%) of 131 assigned white light (difference between groups 29% [95% CI 17-40], p<0.0001). Patients allocated 5-aminolevulinic acid had higher 6-month progression free survival than did those allocated white light (41.0% [32.8-49.2] vs 21.1% [14.0-28.2]; difference between groups 19.9% [9.1-30.7], p=0.0003, Z test) [1]. 5-ALA alone proved to be insufficient in attaining gross total resection without the danger of incurring postoperative neurological deterioration. Furthermore, in the case of functional grade III gliomas, iMRI in combination with functional neuronavigation was significantly superior to the 5-ALA resection technique [2].
| Name | 5-Aminolevulinic Acid Hydrochloride |
|---|---|
| Synonyms |
DELTA-ALA, HCL
5-Aminolevulinic acid hydrochloride;5-Amino-4-oxopentanoic acid hydrochloride δ-Aminolevulinic acid hydrochloride, 5-Amino-4-oxopentanoic acid hydrochloride, 5-Aminolaevulinic acid hydrochloride, ALA EINECS 226-679-5 5-Aminolevulinic acid hydrochloride, 5-Amino-4-oxovaleric acid hydrochloride 5-Aminolevulinic acid hydrochloride, 5-Amino-4-ketovaleric acid hydrochloride Pentanoicacid, 5-amino-4-oxo-, hydrochloride (1:1) Levulinic acid, 5-amino-, hydrochloride (8CI) 5-amino-4-ketovaleric acid hydrochloride TIMTEC-BB SBB003880 5-amino-3-oxopentanoic acid 5-Aminolevulinic acid hydrochloride,δ-Aminolevulinic acid hydrochloride, 5-Amino-4-oxopentanoic acid hydrochloride, 5-Aminolaevulinic acid hydrochloride, ALA 5-AminolevulinicAcidHydrochloride(5-Ala) 5-Aminolevulinic Acid-4-13CCI 5-AMINOLEVULINIC ACID HCL 4-Cboxy-2-oxobutylamine·hydrochloride 5-AMINOLEVULINIC ACID HYDROCHLORIDE δ-aminolevulinic acid hydrochloride inic acid hydrochL 5-Aminolevulinatehydrochloride ä-Aminolevulinic acid hydrochloride 5-AminoL Aminolevulinic acid hydrochloride (USAN) MFCD00012869 DELTA-AMINOLEVULINIC ACID HYDROCHLORIDE CELL CULTUR DELTA-AMINOLEVULINIC ACID HCL 5-AMINO-4-OXOPENTANOICACIDHYDROCHLORIDE(5-AMINOLEVULINICACIDHYDROCHLORIDE) Pentanoic acid, 5-am 5-Aminolevulinic acid/ALT evuL ALA-PDT GAMMA-AMINOLEVULINIC ACID HYDROCHLORIDE DELTA-AMINOLEVULINIC ACID HYDROCHLORIDE 5-Aminolevulinicacidhydrochloride 5-amino-levulinicacihydrochloride(8ci) ALA HCL 5-AMINOLAEVULINIC ACID HYDROCHLORIDE 5-amino-4-oxo-pentanoic acid, hydrochloride (1:1) 5-Aminolevulinic Acid-4-13CHCI 5ALA,5-Aminolevulinic acid hydrochloride Levulan Kerastick Levulinic acid, 5-amino-, hydrochloride 5-Aminolevulinic Acid-5-13CHCI 5-Amino-4-oxopentanoic acid hydrochloride Levulan (TN) 5-Ala Pentanoic acid, 5-amino-4-oxo-, hydrochloride 5-AMinolevulinic Acid HCl (5-ALA HCl) 5-Amino-3-oxopentanoic acid (hydrochloride) 5-AMINO-4-OXOPENTANOIC ACID HCL Gliolan D-AMINOLEVULINIC ACID HCL 5-Aminolevulinic-C Acid HCl δ-Aminolevulinic acid hydrochloride (Assay) 5-Aminolevulinic Acid-5-13CCI ALA HYDROCHLORIDE Levulinicacid,5-amino-,hydrochloride(8Cl) 5-Amino-4-oxopentanoic acid hydrochloride, 5-Aminolaevulinic acid hydrochloride, ALA |
| Description | 5-Aminolevulinic acid HCl is an intermediate in heme biosynthesis in the body and the universal precursor of tetrapyrroles.Target: Others5-Aminolevulinic acid is a non-fluorescent prodrug that leads to intracellular accumulation of fluorescent porphyrins in malignant gliomas-a finding that is under investigation for intraoperative identification and resection of these tumours. Median follow-up was 35.4 months (95% CI 1.0-56.7). Contrast-enhancing tumour was resected completely in 90 (65%) of 139 patients assigned 5-aminolevulinic acid compared with 47 (36%) of 131 assigned white light (difference between groups 29% [95% CI 17-40], p<0.0001). Patients allocated 5-aminolevulinic acid had higher 6-month progression free survival than did those allocated white light (41.0% [32.8-49.2] vs 21.1% [14.0-28.2]; difference between groups 19.9% [9.1-30.7], p=0.0003, Z test) [1]. 5-ALA alone proved to be insufficient in attaining gross total resection without the danger of incurring postoperative neurological deterioration. Furthermore, in the case of functional grade III gliomas, iMRI in combination with functional neuronavigation was significantly superior to the 5-ALA resection technique [2]. |
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| Related Catalog | |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 311.5±27.0 °C at 760 mmHg |
| Melting Point | ~150 °C (dec.) |
| Molecular Formula | C5H10ClNO3 |
| Molecular Weight | 167.59 |
| Flash Point | 142.2±23.7 °C |
| PSA | 80.39000 |
| LogP | -0.79 |
| Appearance | powder |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.482 |
| Storage condition | 2-8°C |
| Water Solubility | H2O: 50 mg/mL |
CHEMICAL IDENTIFICATION
|
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319 |
| Precautionary Statements | P305 + P351 + P338 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
| Hazard Codes | Xi,Xn |
| Risk Phrases | R36/37/38:Irritating to eyes, respiratory system and skin . R66:Repeated exposure may cause skin dryness or cracking. R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . |
| Safety Phrases | S26-S36/37-S37/39 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | OI1640000 |
| HS Code | 2922509090 |
| Precursor 7 | |
|---|---|
| DownStream 6 | |
| HS Code | 2922509090 |
|---|---|
| Summary | 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |