22338-71-2

22338-71-2 structure

Name: Virgaureagenin G
Chemical Name: Polygalacic acid
CAS Number: 22338-71-2
Molecular Formula: C₃₀H₄₈O₆
Molecular Weight: 504.698
Catalog: Biochemical Plant extracts
Create Date: 2018-04-12 08:00:00
Modify Date: 2024-01-02 17:46:30
Polygalacic acid, is a triterpene, isolated from the root of Polygala tenuifolia Willd. Polygalacic acid inhibits MMP expression. Polygalacic acid may have a therapeutic effect in Osteoarthritis (OA) treatment [1]. Polygalacic acid exerts a significant neuroprotective effect on cognitive impairment, PA improves cholinergic system reactivity by inhibiting acetylcholinesterase (AChE) activity, increasing choline acetyltransferase (ChAT) activity, and elevating levels of acetylcholine (Ach) in the hippocampus and frontal cortex[2].

Name	Polygalacic acid
Synonyms	(2b,3b,4a,16a)-2,3,16,23-Tetrahydroxyolean-12-en-28-oic acid Polygalacic Polygalacicacid Virgaureagenin G (2β,3β,5ξ,16α,18α)-2,3,16,23-Tetrahydroxyolean-12-en-28-oic acid Vigaureagenin G Olean-12-en-28-oic acid, 2,3,16,23-tetrahydroxy-, (2β,3β,5ξ,16α,18α)- Polygalac Saeure

Description	Polygalacic acid, is a triterpene, isolated from the root of Polygala tenuifolia Willd. Polygalacic acid inhibits MMP expression. Polygalacic acid may have a therapeutic effect in Osteoarthritis (OA) treatment [1]. Polygalacic acid exerts a significant neuroprotective effect on cognitive impairment, PA improves cholinergic system reactivity by inhibiting acetylcholinesterase (AChE) activity, increasing choline acetyltransferase (ChAT) activity, and elevating levels of acetylcholine (Ach) in the hippocampus and frontal cortex[2].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Metabolic Enzyme/Protease >> MMP Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> AChE
In Vitro	Polygalacic acid (0-100 μM; 24 hours) significantly decreases the mRNAexpressions of MMP-3, MMP-9, MMP-13, and COX-2, which are significantly increased by IL-1β, in a dose-dependent manner[1]. Polygalacic acid (0-100 μM; 6 hours) decreases the expression of phosphor-p38, phosphor-Erk, and phosphor-Jnk induced by IL-1β, phosphor-p65 is not reduced by polygalacic acid[1]. RT-PCR[1] Cell Line: Chondrocyte cells Concentration: 50 μM; 100 μM Incubation Time: 24 hours Result: Suppressed IL-1β-induced COX-2, MMP3, MMP9, and MMP13 mRNA expression. Western Blot Analysis[1] Cell Line: Chondrocyte cells Concentration: 50 μM; 100 μM Incubation Time: 6 hours Result: Inhibited the IL-1β-induced activation of the MAPK pathway in chondrocytes.
References	[1]. Xu K, et al. Polygalacic acid inhibits MMPs expression and osteoarthritis via Wnt/β-catenin and MAPK signal pathways suppression. Int Immunopharmacol. 2018 Oct;63:246-252. [2]. Guo C, et al. Neuroprotective effects of polygalacic acid on scopolamine-induced memory deficits in mice. Phytomedicine. 2016 Feb 15;23(2):149-55.

Density	1.2±0.1 g/cm3
Boiling Point	638.1±55.0 °C at 760 mmHg
Melting Point	315-318ºC
Molecular Formula	C₃₀H₄₈O₆
Molecular Weight	504.698
Flash Point	353.7±28.0 °C
Exact Mass	504.345093
PSA	118.22000
LogP	5.03
Vapour Pressure	0.0±4.3 mmHg at 25°C
Index of Refraction	1.593

HS Code	29163990

1033766-70-9

22338-71-2

Literature: Yoshikawa, Masayuki; Li, Xuezheng; Nishida, Eriko; Nakamura, Seikou; Matsuda, Hisashi; Muraoka, Osamu; Morikawa, Toshio Chemical and Pharmaceutical Bulletin, 2008 , vol. 56, # 4 p. 559 - 568