Virgaureagenin G
Virgaureagenin G structure
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Common Name | Virgaureagenin G | ||
|---|---|---|---|---|
| CAS Number | 22338-71-2 | Molecular Weight | 504.698 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 638.1±55.0 °C at 760 mmHg | |
| Molecular Formula | C30H48O6 | Melting Point | 315-318ºC | |
| MSDS | N/A | Flash Point | 353.7±28.0 °C | |
Use of Virgaureagenin GPolygalacic acid, is a triterpene, isolated from the root of Polygala tenuifolia Willd. Polygalacic acid inhibits MMP expression. Polygalacic acid may have a therapeutic effect in Osteoarthritis (OA) treatment [1]. Polygalacic acid exerts a significant neuroprotective effect on cognitive impairment, PA improves cholinergic system reactivity by inhibiting acetylcholinesterase (AChE) activity, increasing choline acetyltransferase (ChAT) activity, and elevating levels of acetylcholine (Ach) in the hippocampus and frontal cortex[2]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | Polygalacic acid |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Polygalacic acid, is a triterpene, isolated from the root of Polygala tenuifolia Willd. Polygalacic acid inhibits MMP expression. Polygalacic acid may have a therapeutic effect in Osteoarthritis (OA) treatment [1]. Polygalacic acid exerts a significant neuroprotective effect on cognitive impairment, PA improves cholinergic system reactivity by inhibiting acetylcholinesterase (AChE) activity, increasing choline acetyltransferase (ChAT) activity, and elevating levels of acetylcholine (Ach) in the hippocampus and frontal cortex[2]. |
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| Related Catalog | |
| In Vitro | Polygalacic acid (0-100 μM; 24 hours) significantly decreases the mRNAexpressions of MMP-3, MMP-9, MMP-13, and COX-2, which are significantly increased by IL-1β, in a dose-dependent manner[1]. Polygalacic acid (0-100 μM; 6 hours) decreases the expression of phosphor-p38, phosphor-Erk, and phosphor-Jnk induced by IL-1β, phosphor-p65 is not reduced by polygalacic acid[1]. RT-PCR[1] Cell Line: Chondrocyte cells Concentration: 50 μM; 100 μM Incubation Time: 24 hours Result: Suppressed IL-1β-induced COX-2, MMP3, MMP9, and MMP13 mRNA expression. Western Blot Analysis[1] Cell Line: Chondrocyte cells Concentration: 50 μM; 100 μM Incubation Time: 6 hours Result: Inhibited the IL-1β-induced activation of the MAPK pathway in chondrocytes. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 638.1±55.0 °C at 760 mmHg |
| Melting Point | 315-318ºC |
| Molecular Formula | C30H48O6 |
| Molecular Weight | 504.698 |
| Flash Point | 353.7±28.0 °C |
| Exact Mass | 504.345093 |
| PSA | 118.22000 |
| LogP | 5.03 |
| Vapour Pressure | 0.0±4.3 mmHg at 25°C |
| Index of Refraction | 1.593 |
| InChIKey | KGGGRGBDMBZXKF-YQJGEOIASA-N |
| SMILES | CC1(C)CCC2(C(=O)O)C(O)CC3(C)C(=CCC4C5(C)CC(O)C(O)C(C)(CO)C5CCC43C)C2C1 |
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| HS Code | 29163990 |
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This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
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Virgaureagenin G CAS#:22338-71-2 |
| Literature: Yoshikawa, Masayuki; Li, Xuezheng; Nishida, Eriko; Nakamura, Seikou; Matsuda, Hisashi; Muraoka, Osamu; Morikawa, Toshio Chemical and Pharmaceutical Bulletin, 2008 , vol. 56, # 4 p. 559 - 568 |
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Virgaureagenin G CAS#:22338-71-2 |
| Literature: Yoshikawa, Masayuki; Li, Xuezheng; Nishida, Eriko; Nakamura, Seikou; Matsuda, Hisashi; Muraoka, Osamu; Morikawa, Toshio Chemical and Pharmaceutical Bulletin, 2008 , vol. 56, # 4 p. 559 - 568 |
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| Literature: Hernandez-Carlos, Beatriz; Carmona-Pineda, Miriam; Villanueva-Canongo, Claudia; Lopez-Olguin, Jesus F.; Aragon-Garcia, Agustin; Joseph-Nathan, Pedro Magnetic Resonance in Chemistry, 2009 , vol. 47, # 11 p. 994 - 1003 |
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Detail
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| Literature: Hernandez-Carlos, Beatriz; Carmona-Pineda, Miriam; Villanueva-Canongo, Claudia; Lopez-Olguin, Jesus F.; Aragon-Garcia, Agustin; Joseph-Nathan, Pedro Magnetic Resonance in Chemistry, 2009 , vol. 47, # 11 p. 994 - 1003 |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 1 | |
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| DownStream 0 | |
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| (2b,3b,4a,16a)-2,3,16,23-Tetrahydroxyolean-12-en-28-oic acid |
| Polygalacic |
| Polygalacicacid |
| Virgaureagenin G |
| (2β,3β,5ξ,16α,18α)-2,3,16,23-Tetrahydroxyolean-12-en-28-oic acid |
| Vigaureagenin G |
| Polygalac Saeure |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the CAS number of Polygalacic acid? |
| A: CAS number of Polygalacic acid is 22338-71-2. |
| Q: What is the polar surface area (PSA) of Polygalacic acid? |
| A: Polar surface area (PSA) of Polygalacic acid is 118.22000. |
| Q: What is the boiling point of Polygalacic acid? |
| A: Boiling point of Polygalacic acid is 638.1±55.0 °C at 760 mmHg. |
| Q: What are the upstream materials of Polygalacic acid? |
| A: Related upstream materials(CAS) of Polygalacic acid: 1033766-70-9. |
| Q: What is the English name of Polygalacic acid? |
| A: The English name of Polygalacic acid is Polygalacic acid. |
| Q: What is the InChIKey of Polygalacic acid? |
| A: InChIKey of Polygalacic acid is KGGGRGBDMBZXKF-YQJGEOIASA-N. |
| Q: What is the SMILES notation of Polygalacic acid? |
| A: SMILES notation of Polygalacic acid is CC1(C)CCC2(C(=O)O)C(O)CC3(C)C(=CCC4C5(C)CC(O)C(O)C(C)(CO)C5CCC43C)C2C1. |
| Q: What is the molecular formula of Polygalacic acid? |
| A: Molecular formula of Polygalacic acid is C30H48O6. |
| Q: What is the LogP of Polygalacic acid? |
| A: LogP of Polygalacic acid is 5.03. |
| Q: What is the molecular weight of Polygalacic acid? |
| A: Molecular weight of Polygalacic acid is 504.698. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |
| naturewill |