Top Suppliers:I want be here
Related CAS#:
486-86-2 20013-22-3
103394-70-3 158729-32-9
58068-80-7 158729-30-7
10162-76-2 158729-29-4
158729-28-3 101622-73-5
2287285-67-8 2287331-86-4
2287282-91-9 2287282-98-6
2287339-96-0 2287280-06-0
2287340-00-3 2287302-87-6
2287318-93-6 2287280-40-2

486-86-2

486-86-2 structure
486-86-2 structure
  • Name: N-methylcytisine
  • Chemical Name: N-Methylcytisine
  • CAS Number: 486-86-2
  • Molecular Formula: C12H16N2O
  • Molecular Weight: 204.27
  • Catalog: Biochemical Chinese herbal medicine ingredients
  • Create Date: 2018-09-22 23:17:15
  • Modify Date: 2025-08-23 15:14:22
  • N-Methylcytisine (Caulophylline), a tricyclic quinolizidine alkaloid, exerts hypoglycaemic, analgesic and anti-inflammatory activities. N-methylcytisine is a selective ligand of nicotinic receptors of acetylcholine in the central nervous system and has a high affinity (Kd = 50 nM) to nicotinic acetylcholine receptors (nAChR) from squid optical ganglia[1][2].
Name N-Methylcytisine
Synonyms N-methylcytisine
N－Methylcytisine
1,5-Methano-8H-pyrido[1,2-a][1,5]diazocin-8-one, 1,2,3,4,5,6-hexahydro-3-methyl-
1,5-Methano-8H-pyrido[1,2-a][1,5]diazocin-8-one, 1,2,3,4,5,6-hexahydro-3-methyl-, (1R)-
(1R)-11-Methyl-7,11-diazatricyclo[7.3.1.0]trideca-2,4-dien-6-one
11-Methyl-7,11-diazatricyclo[7.3.1.0]trideca-2,4-dien-6-one
1,2,3,4,5,6-Hexahydro-3-methyl-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-one
Caulophylline
3-methyl-1,2,3,4,5,6-hexahydro-8H-1,5-methanopyrido[1,2-a][1,5]diazocin-8-one
(1R)-3-methyl-1,2,3,4,5,6-hexahydro-8H-1,5-methanopyrido[1,2-a][1,5]diazocin-8-one
Description N-Methylcytisine (Caulophylline), a tricyclic quinolizidine alkaloid, exerts hypoglycaemic, analgesic and anti-inflammatory activities. N-methylcytisine is a selective ligand of nicotinic receptors of acetylcholine in the central nervous system and has a high affinity (Kd = 50 nM) to nicotinic acetylcholine receptors (nAChR) from squid optical ganglia[1][2].
Related Catalog
Target

kd: 50 nM (nicotinic acetylcholine receptors)[2]

References

[1]. Jiao YF, et al. N-Methylcytisine Ameliorates Dextran-Sulfate-Sodium-Induced Colitis in Mice by Inhibiting the Inflammatory Response. Molecules. 2018 Feb 25;23(3). pii: E510.

[2]. Pliashkevich IuG, et al. [N-methylcytisine--a selective ligand of nicotinic receptors of acetylcholine in the CNS]. Biull Eksp Biol Med. 1987 Dec;104(12):690-2.
Density 1.2±0.1 g/cm3
Boiling Point 400.8±34.0 °C at 760 mmHg
Melting Point 137-139ºC
Molecular Formula C12H16N2O
Molecular Weight 204.27
Flash Point 191.9±18.0 °C
Exact Mass 204.126266
PSA 25.24000
LogP 0.46
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.616

CHEMICAL IDENTIFICATION

RTECS NUMBER :
HA4400000
CHEMICAL NAME :
Cytisine, 12-methyl-
CAS REGISTRY NUMBER :
486-86-2
BEILSTEIN REFERENCE NO. :
0012448
LAST UPDATED :
199612
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C12-H16-N2-O
MOLECULAR WEIGHT :
204.30

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
511 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - muscle contraction or spasticity
REFERENCE :
BJPCBM British Journal of Pharmacology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.34- 1968- Volume(issue)/page/year: 35,161,1969
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
51 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - muscle contraction or spasticity
REFERENCE :
BJPCBM British Journal of Pharmacology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.34- 1968- Volume(issue)/page/year: 35,161,1969
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
22 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 79,334,1943
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
160 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year: 7,24,1983
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Precautionary Statements P301 + P312 + P330
Hazard Codes Xn
Risk Phrases 22
RIDADR NONH for all modes of transport
RTECS HA4400000
50-00-0 structure

50-00-0

485-35-8 structure

485-35-8

~99%

486-86-2 structure

486-86-2

Literature: Frigerio, Fabio; Haseler, Claire A.; Gallagher, Timothy Synlett, 2010 , # 5 p. 729 - 730
485-35-8 structure

485-35-8

74-88-4 structure

74-88-4

~%

486-86-2 structure

486-86-2

Literature: Tsypysheva; Koval'skaya; Makara; Lobov; Petrenko; Galkin; Sapozhnikova; Zarudii; Yunusov Chemistry of Natural Compounds, 2012 , vol. 48, # 4 p. 629 - 634 Khim. Prir. Soedin., 2012 , p. 565 - 570
Precursor  3

DownStream  0

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Chemsrc provides CAS#:486-86-2 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 486-86-2 | Chemsrc address: https://m.chemsrc.com/en/baike/831151.html

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved