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73-05-2

73-05-2 structure

73-05-2 structure

Name: Phentolamine hydrochloride
Chemical Name: 3-[N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-4-methylanilino]phenol,hydrochloride
CAS Number: 73-05-2
Molecular Formula: C₁₇H₂₀ClN₃O
Molecular Weight: 317.813
Catalog: API Circulatory system medication Peripheral vasodilator
Create Date: 2018-04-14 08:00:00
Modify Date: 2025-08-25 19:43:53
Phentolamine hydrochloride is an orally active adrenergic α receptor-blocking agent[1].

Name	3-[N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-4-methylanilino]phenol,hydrochloride
Synonyms	3-(((4,5-Dihydro-1H-imidazol-2-yl)methyl)(4-methylphenyl)amino)phenol Hydrochloride 2-(m-Hydroxy-N-p-tolylanilinomethyl)-2-imidazoline Hydrochloride 3-[[(4,5-Dihydro-1H-imidazol-2-yl)methyl](4-methylphenyl)amino]phenol Hydrochloride m-(N-(2-Imidazolin-2-ylmethyl)-p-toluidino)phenol monohydrochloride Fentolamine Hydrochloride 2-[N-(m-Hydroxyphenyl)-p-toluidinomethyl]imidazoline Hydrochloride Phenol, 3-(((4,5-dihydro-1H-imidazol-2-yl)methyl)(4-methylphenyl)amino), monohydrochloride phentolamin hydrochloride 3-[(4,5-Dihydro-1H-imidazol-2-ylmethyl)(4-methylphenyl)amino]phenol hydrochloride (1:1) 2-[N-(3-Hydroxyphenyl)-p-toluidinomethyl]-2-imidazolidine hydrochloride EINECS 200-793-5 Phentolamine hydrochloride Phentolamine HCl 2-(N'-p-Tolyl-N'-m-hydroxyphenylaminomethyl)-2-imidazoline Hydrochloride Phenol, m-(N-(2-imidazolin-2-ylmethyl)-p-toluidino)-, monohydrochloride (8CI) Prestwick_386 phentolamine MFCD00079268 3-[N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-p-toluidino]-phenol,hydrochloride 50-60-2 (Parent) 3-[N-(4,5-Dihydro-1H-imidazol-2-ylmethyl)-p-toluidino]-phenol,Hydrochlorid Regitine hydrochloride Phenol, 3-[[(4,5-dihydro-1H-imidazol-2-yl)methyl](4-methylphenyl)amino]-, hydrochloride (1:1)

Description	Phentolamine hydrochloride is an orally active adrenergic α receptor-blocking agent[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Metabolic Disease
References	[1]. P A Majid, et al. Phentolamine for vasodilator treatment of severe heart-failure. Lancet. 1971 Oct 2;2(7727):719-24.

Boiling Point	569ºC at 760 mmHg
Melting Point	>230ºC(dec.)
Molecular Formula	C₁₇H₂₀ClN₃O
Molecular Weight	317.813
Flash Point	297.9ºC
Exact Mass	317.129486
PSA	47.86000
LogP	3.40680
Appearance	powder \| white to off-white
Storage condition	-20°C Freezer
Water Solubility	methanol: 10 mg/mL, clear, colorless

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SL0701000

CHEMICAL NAME :: Phenol, 3-(((4,5-dihydro-1H-imidazol-2-yl)methyl)(4-methylphe nyl)amino)-, monohydrochloride

CAS REGISTRY NUMBER :: 73-05-2

LAST UPDATED :: 199009

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C17-H19-N3-O.Cl-H

MOLECULAR WEIGHT :: 317.85

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 71,70,1949

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 275 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 71,70,1949

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 71,70,1949

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Precautionary Statements	P301 + P312 + P330
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn: Harmful;
Risk Phrases	R22
Safety Phrases	S22-S24/25
RIDADR	UN 3249
WGK Germany	3
RTECS	SL0701000
Packaging Group	III
Hazard Class	6.1(b)

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